Dacuronium bromide: Difference between revisions

Dacuronium bromide
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Latest revision as of 00:00, 25 February 2025

A non-depolarizing neuromuscular blocking agent

Dacuronium bromide is a non-depolarizing neuromuscular blocking agent used in anesthesia to induce muscle relaxation during surgery or mechanical ventilation. It is part of the aminosteroid class of neuromuscular blockers.

Mechanism of Action[edit]

Dacuronium bromide works by competitively inhibiting the action of acetylcholine at the neuromuscular junction. It binds to the nicotinic acetylcholine receptor on the motor end plate, preventing acetylcholine from binding and triggering muscle contraction. This results in muscle paralysis, which is reversible with the administration of acetylcholinesterase inhibitors such as neostigmine.

Pharmacokinetics[edit]

Dacuronium bromide is administered intravenously. It has a rapid onset of action, typically within 2 to 3 minutes, and a duration of action of approximately 30 to 60 minutes. The drug is metabolized in the liver and excreted primarily in the urine.

Clinical Use[edit]

Dacuronium bromide is used in various surgical procedures to facilitate endotracheal intubation and provide muscle relaxation. It is also used in the intensive care setting to facilitate mechanical ventilation in patients who require prolonged respiratory support.

Side Effects[edit]

Common side effects of dacuronium bromide include hypotension, tachycardia, and bronchospasm. Rarely, it may cause anaphylaxis or prolonged neuromuscular blockade, especially in patients with hepatic or renal impairment.

Contraindications[edit]

Dacuronium bromide is contraindicated in patients with known hypersensitivity to the drug or any of its components. Caution is advised in patients with myasthenia gravis or other neuromuscular disorders.

Related pages[edit]

Dacuronium bromide chemical structure

@@ Line 1: / Line 1: @@
-'''Dacuronium Bromide''' is a non-depolarizing [[neuromuscular-blocking drug]] or [[neuromuscular-blocking agent]] and is used in modern [[anaesthesia]] at the stage of surgeries to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation. It is a part of the [[aminosteroid]] group of neuromuscular-blocking drugs and is generally used in the form of Dacuronium Bromide salts.
+{{Short description|A non-depolarizing neuromuscular blocking agent}}
+{{Drugbox
+| verifiedfields = changed
+| verifiedrevid = 477002123
+| image = Dacuronium_bromide.svg
+| image_size = 250px
+| image_alt = Structural formula of Dacuronium bromide
+}}
-==Pharmacology==
+'''Dacuronium bromide''' is a [[non-depolarizing neuromuscular blocking agent]] used in [[anesthesia]] to induce [[muscle relaxation]] during [[surgery]] or [[mechanical ventilation]]. It is part of the [[aminosteroid]] class of neuromuscular blockers.
-Dacuronium Bromide acts by competing for the [[cholinergic]] receptors at the motor end-plate. This action is antagonized by [[acetylcholinesterase inhibitors]], such as neostigmine and edrophonium. Dacuronium Bromide has a moderately rapid onset, and its lack of significant cardiovascular side effects and its lack of histamine release, have made it popular for use in patients with cardiovascular compromise.
+==Mechanism of Action==
+Dacuronium bromide works by competitively inhibiting the action of [[acetylcholine]] at the [[neuromuscular junction]]. It binds to the [[nicotinic acetylcholine receptor]] on the [[motor end plate]], preventing acetylcholine from binding and triggering [[muscle contraction]]. This results in [[muscle paralysis]], which is reversible with the administration of [[acetylcholinesterase inhibitors]] such as [[neostigmine]].
+==Pharmacokinetics==
+Dacuronium bromide is administered intravenously. It has a rapid onset of action, typically within 2 to 3 minutes, and a duration of action of approximately 30 to 60 minutes. The drug is metabolized in the [[liver]] and excreted primarily in the [[urine]].
 ==Clinical Use==
-Dacuronium Bromide is often used for providing muscle relaxation for intubation, which is the insertion of a flexible plastic tube into the trachea to maintain an open airway or to serve as a conduit through which to administer certain drugs. It is also used for muscle relaxation during surgery, particularly during procedures that require the patient to be under general anesthesia.
+Dacuronium bromide is used in various surgical procedures to facilitate [[endotracheal intubation]] and provide muscle relaxation. It is also used in the intensive care setting to facilitate mechanical ventilation in patients who require prolonged respiratory support.
 ==Side Effects==
-Like all [[neuromuscular-blocking agents]], Dacuronium Bromide can cause a range of side effects. These can include [[hypotension]], [[tachycardia]], and [[bronchospasm]]. In rare cases, it can cause anaphylaxis, a severe and potentially life-threatening allergic reaction.
+Common side effects of dacuronium bromide include [[hypotension]], [[tachycardia]], and [[bronchospasm]]. Rarely, it may cause [[anaphylaxis]] or prolonged neuromuscular blockade, especially in patients with [[hepatic]] or [[renal impairment]].
+==Contraindications==
+Dacuronium bromide is contraindicated in patients with known hypersensitivity to the drug or any of its components. Caution is advised in patients with [[myasthenia gravis]] or other neuromuscular disorders.
-==See Also==
+==Related pages==
 * [[Neuromuscular-blocking drug]]
-* [[Anaesthesia]]
+* [[Anesthesia]]
+* [[Acetylcholine]]
 * [[Endotracheal intubation]]
-* [[Acetylcholinesterase inhibitors]]
-[[Category:Pharmacology]]
+[[Category:Neuromuscular blockers]]
-[[Category:Anaesthesia]]
+[[Category:Aminosteroids]]
-[[Category:Neuromuscular-blocking drugs]]
+<gallery>
-{{pharma-stub}}
+File:Dacuronium_bromide.svg|Dacuronium bromide chemical structure
+</gallery>