Xanthochromia: Difference between revisions

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'''Xanthochromia''' refers to the yellowish appearance of [[cerebrospinal fluid]] that occurs due to the presence of [[bilirubin]], a breakdown product of [[hemoglobin]]. This condition is typically associated with [[subarachnoid hemorrhage]], a type of [[stroke]] caused by bleeding into the space surrounding the brain.
{{SI}}
 
{{Infobox medical condition
| name            = Xanthochromia
| image          = [[File:Xanthochromia.jpg]]
| caption        = Cerebrospinal fluid showing xanthochromia
| field          = [[Neurology]]
| symptoms        = Yellowish discoloration of [[cerebrospinal fluid]]
| causes          = [[Subarachnoid hemorrhage]], [[hyperbilirubinemia]], [[elevated protein levels]]
| diagnosis      = [[Lumbar puncture]], [[spectrophotometry]]
| differential    = [[Jaundice]], [[carotenemia]]
| treatment      = Address underlying cause
| frequency      = Common in cases of [[subarachnoid hemorrhage]]
}}
{{DISPLAYTITLE:Xanthochromia}}
== Xanthochromia ==
[[File:Xanthochromia.jpg|left|thumb|Xanthochromia in cerebrospinal fluid]]
'''Xanthochromia''' is a term used in medicine to describe the yellowish discoloration of the [[cerebrospinal fluid]] (CSF) due to the presence of bilirubin. This condition is often associated with [[subarachnoid hemorrhage]] (SAH) and is an important diagnostic indicator in the evaluation of patients with suspected [[intracranial bleeding]].
== Causes ==
== Causes ==
Xanthochromia is most commonly caused by a subarachnoid hemorrhage. This can occur due to a ruptured [[brain aneurysm]], [[arteriovenous malformation]], or [[head injury]]. Less commonly, xanthochromia can be caused by severe [[jaundice]], certain metabolic disorders, or a reaction to certain drugs.
Xanthochromia occurs when there is a breakdown of [[red blood cells]] in the CSF, leading to the release of [[hemoglobin]] and its subsequent conversion to bilirubin. This process can take several hours to days, which is why xanthochromia is typically not present immediately after a hemorrhage.
 
== Diagnosis ==
== Diagnosis ==
The diagnosis of xanthochromia is typically made through a [[lumbar puncture]], also known as a spinal tap. During this procedure, a small amount of cerebrospinal fluid is removed from the lower back and examined under a microscope. If the fluid appears yellow, this is indicative of xanthochromia. Additional tests may be performed to determine the underlying cause of the condition.
The presence of xanthochromia is typically assessed through a [[lumbar puncture]], where a sample of CSF is collected and analyzed. The CSF is examined for its color, and spectrophotometry may be used to detect bilirubin levels more accurately. Xanthochromia is a key finding that helps differentiate between a traumatic tap and a true subarachnoid hemorrhage.
 
== Clinical Significance ==
== Treatment ==
Detecting xanthochromia is crucial in the diagnosis of subarachnoid hemorrhage, especially when [[computed tomography]] (CT) scans are inconclusive. It helps in confirming the presence of bleeding in the [[subarachnoid space]], which can be life-threatening if not treated promptly.
Treatment for xanthochromia focuses on addressing the underlying cause of the condition. This may involve surgery to repair a ruptured aneurysm, medication to control symptoms, or other interventions as appropriate.
== Management ==
 
Once xanthochromia is detected and a diagnosis of subarachnoid hemorrhage is confirmed, immediate medical intervention is required. Treatment may involve surgical procedures such as [[clipping]] or [[coiling]] of an aneurysm, along with supportive care to manage symptoms and prevent complications.
== Prognosis ==
The prognosis for individuals with xanthochromia varies widely and depends on the underlying cause of the condition. In cases where the condition is caused by a subarachnoid hemorrhage, the prognosis can be poor, as this is a serious and potentially life-threatening condition. However, with prompt diagnosis and treatment, many individuals can recover.
 
== See also ==
== See also ==
* [[Subarachnoid hemorrhage]]
* [[Subarachnoid hemorrhage]]
* [[Cerebrospinal fluid]]
* [[Cerebrospinal fluid]]
* [[Bilirubin]]
* [[Lumbar puncture]]
* [[Hemoglobin]]
* [[Intracranial hemorrhage]]
 
[[Category:Medical signs]]
[[Category:Neurological disorders]]
[[Category:Neurology]]
[[Category:Symptoms and signs]]
{{Medicine-stub}}

Latest revision as of 17:56, 12 April 2025

Editor-In-Chief: Prab R Tumpati, MD
Obesity, Sleep & Internal medicine
Founder, WikiMD Wellnesspedia &
W8MD medical weight loss NYC and sleep center NYC

Xanthochromia
Synonyms N/A
Pronounce N/A
Specialty N/A
Symptoms Yellowish discoloration of cerebrospinal fluid
Complications N/A
Onset N/A
Duration N/A
Types N/A
Causes Subarachnoid hemorrhage, hyperbilirubinemia, elevated protein levels
Risks N/A
Diagnosis Lumbar puncture, spectrophotometry
Differential diagnosis Jaundice, carotenemia
Prevention N/A
Treatment Address underlying cause
Medication N/A
Prognosis N/A
Frequency Common in cases of subarachnoid hemorrhage
Deaths N/A


Xanthochromia[edit]

Xanthochromia in cerebrospinal fluid

Xanthochromia is a term used in medicine to describe the yellowish discoloration of the cerebrospinal fluid (CSF) due to the presence of bilirubin. This condition is often associated with subarachnoid hemorrhage (SAH) and is an important diagnostic indicator in the evaluation of patients with suspected intracranial bleeding.

Causes[edit]

Xanthochromia occurs when there is a breakdown of red blood cells in the CSF, leading to the release of hemoglobin and its subsequent conversion to bilirubin. This process can take several hours to days, which is why xanthochromia is typically not present immediately after a hemorrhage.

Diagnosis[edit]

The presence of xanthochromia is typically assessed through a lumbar puncture, where a sample of CSF is collected and analyzed. The CSF is examined for its color, and spectrophotometry may be used to detect bilirubin levels more accurately. Xanthochromia is a key finding that helps differentiate between a traumatic tap and a true subarachnoid hemorrhage.

Clinical Significance[edit]

Detecting xanthochromia is crucial in the diagnosis of subarachnoid hemorrhage, especially when computed tomography (CT) scans are inconclusive. It helps in confirming the presence of bleeding in the subarachnoid space, which can be life-threatening if not treated promptly.

Management[edit]

Once xanthochromia is detected and a diagnosis of subarachnoid hemorrhage is confirmed, immediate medical intervention is required. Treatment may involve surgical procedures such as clipping or coiling of an aneurysm, along with supportive care to manage symptoms and prevent complications.

See also[edit]