Thiamphenicol

Thiamphenicol is a chemical compound that is primarily used as an antibiotic. It is a derivative of chloramphenicol and is manufactured synthetically. Thiamphenicol is known for its broad-spectrum antibiotic properties, which means it is effective against a wide range of bacteria.

History

Thiamphenicol was first synthesized in the 1950s as a more stable alternative to chloramphenicol. It was developed by the pharmaceutical industry in an effort to overcome the toxic side effects associated with chloramphenicol.

Pharmacology

Thiamphenicol works by inhibiting protein synthesis in bacteria, thereby preventing their growth and reproduction. It binds to the ribosome of the bacteria, specifically the 50S subunit, and prevents the addition of new amino acids to the growing peptide chain.

Medical Uses

Thiamphenicol is used to treat a variety of bacterial infections, including respiratory tract infections, urinary tract infections, and skin infections. It is also used in veterinary medicine for the treatment of various animal diseases.

Side Effects

Like all antibiotics, thiamphenicol can cause side effects. These may include nausea, vomiting, and diarrhea. In rare cases, it can cause serious side effects such as aplastic anemia and gray baby syndrome.

See Also

• Chloramphenicol
• Antibiotic
• Pharmaceutical industry

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  Thiamphenicol structure
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  Thiamphenicol space-filling model