JWH-185: Difference between revisions

Latest revision as of 03:55, 13 February 2025

JWH-185[edit]

JWH-185 is a synthetic cannabinoid that acts as a potent agonist at the cannabinoid receptors. It is part of the naphthoylindole family of compounds, which are known for their ability to mimic the effects of tetrahydrocannabinol (THC), the primary psychoactive component of cannabis.

Chemical Properties[edit]

JWH-185 is chemically classified as a naphthoylindole, which is a subclass of synthetic cannabinoids. The chemical structure of JWH-185 includes a naphthalene group attached to an indole core, which is a common feature among compounds in this class. The specific chemical formula for JWH-185 is C25H23NO, and it has a molecular weight of 353.46 g/mol.

Pharmacology[edit]

JWH-185 functions as a full agonist at both the CB1 and CB2 cannabinoid receptors. These receptors are part of the endocannabinoid system, which plays a role in regulating various physiological processes such as mood, appetite, and pain sensation. The binding affinity of JWH-185 for these receptors is similar to that of other synthetic cannabinoids, making it a potent psychoactive substance.

Legal Status[edit]

Due to its psychoactive properties and potential for abuse, JWH-185, like many other synthetic cannabinoids, has been subject to legal restrictions in various countries. It is often included in legislation that targets "designer drugs" or "research chemicals" that are not intended for human consumption.

Synthesis[edit]

The synthesis of JWH-185 involves the reaction of a naphthoyl chloride with an indole derivative. This process is similar to the synthesis of other naphthoylindoles and requires careful control of reaction conditions to ensure the desired product is obtained.

Related Pages[edit]

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-'''JWH-185''' is a synthetic cannabinoid from the naphthoylindole family, which acts as a full agonist at both the CB₁ and CB₂ cannabinoid receptors, but with moderate selectivity for CB₂. It is one of the few synthetic cannabinoids to have been identified as an ingredient in 'herbal' smoking blends.
+== JWH-185 ==
-==Chemistry==
+[[File:JWH-185.png|thumb|right|Chemical structure of JWH-185]]
-JWH-185 is a member of the [[naphthoylindole]] family of synthetic cannabinoids. It is structurally related to other synthetic cannabinoids such as [[JWH-018]] and [[JWH-073]], but differs in that it has a methoxy group at the 5 position of the naphthoyl ring.
-==Pharmacology==
+'''JWH-185''' is a synthetic [[cannabinoid]] that acts as a potent agonist at the [[cannabinoid receptor]]s. It is part of the [[naphthoylindole]] family of compounds, which are known for their ability to mimic the effects of [[tetrahydrocannabinol]] (THC), the primary psychoactive component of [[cannabis]].
-JWH-185 acts as a full [[agonist]] at both the CB₁ and CB₂ [[cannabinoid receptors]]. It has moderate selectivity for CB₂, with a binding affinity of 9.0 nM at CB₁ and 2.94 nM at CB₂. This makes it one of the few synthetic cannabinoids to show selectivity for CB₂.
-==Effects==
+=== Chemical Properties ===
-The effects of JWH-185 are similar to those of other synthetic cannabinoids and include [[euphoria]], [[relaxation]], and [[altered perception]]. However, due to its full agonist activity at both cannabinoid receptors, it may also produce unwanted side effects such as [[anxiety]], [[paranoia]], and [[tachycardia]].
+JWH-185 is chemically classified as a naphthoylindole, which is a subclass of synthetic cannabinoids. The chemical structure of JWH-185 includes a naphthalene group attached to an indole core, which is a common feature among compounds in this class. The specific chemical formula for JWH-185 is C25H23NO, and it has a molecular weight of 353.46 g/mol.
-==Legal status==
+=== Pharmacology ===
-The legal status of JWH-185 varies by country. In the United States, it is a Schedule I controlled substance under the [[Controlled Substances Act]]. In the United Kingdom, it is a Class B drug under the [[Misuse of Drugs Act]].
+JWH-185 functions as a full agonist at both the [[CB1 receptor|CB1]] and [[CB2 receptor|CB2]] cannabinoid receptors. These receptors are part of the [[endocannabinoid system]], which plays a role in regulating various physiological processes such as mood, appetite, and pain sensation. The binding affinity of JWH-185 for these receptors is similar to that of other synthetic cannabinoids, making it a potent psychoactive substance.
-==See also==
+=== Legal Status ===
+Due to its psychoactive properties and potential for abuse, JWH-185, like many other synthetic cannabinoids, has been subject to legal restrictions in various countries. It is often included in legislation that targets "designer drugs" or "research chemicals" that are not intended for human consumption.
+=== Synthesis ===
+The synthesis of JWH-185 involves the reaction of a naphthoyl chloride with an indole derivative. This process is similar to the synthesis of other naphthoylindoles and requires careful control of reaction conditions to ensure the desired product is obtained.
+== Related Pages ==
 * [[Synthetic cannabinoids]]
 * [[Cannabinoid receptor]]
+* [[Endocannabinoid system]]
 * [[JWH-018]]
-* [[JWH-073]]
+* [[Naphthoylindole]]
-==References==
-<references />
 [[Category:Synthetic cannabinoids]]
-[[Category:Naphthoylindoles]]
+[[Category:Designer drugs]]
-[[Category:CB1 receptor agonists]]
-[[Category:CB2 receptor agonists]]
-{{pharmacology-stub}}
-{{drug-stub}}