CUMYL-THPINACA: Difference between revisions

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'''CUMYL-THPINACA''' is a synthetic cannabinoid that is used as an active ingredient in synthetic cannabis products. It is a potent agonist for the CB1 receptor, with a binding affinity of 5.5 nM, making it approximately 33 times more potent than THC. CUMYL-THPINACA was first identified in a herbal product in Hungary in 2015, and has since been identified in numerous other countries.
{{Short description|Synthetic cannabinoid}}
{{Drugbox
| image = CUMYL-THPINACA.png
| image_size = 250px
| image_alt = Chemical structure of CUMYL-THPINACA
| image_caption = Chemical structure of CUMYL-THPINACA
}}


==Chemistry==
'''CUMYL-THPINACA''' is a synthetic cannabinoid that has been used in scientific research and is often found in synthetic cannabis products. It is known for its potent agonistic activity at the [[cannabinoid receptor]]s.
CUMYL-THPINACA is a member of the [[cannabinoid]] class of psychoactive substances. It is structurally related to other synthetic cannabinoids such as [[CUMYL-PINACA]], but differs in that it has a tetrahydroindazole base instead of an indazole base.
 
==Chemical structure and properties==
CUMYL-THPINACA is classified as an indazole-based synthetic cannabinoid. Its chemical structure includes a cumyl group attached to an indazole core, with a pentyl side chain. This structure is similar to other synthetic cannabinoids, which are designed to mimic the effects of [[tetrahydrocannabinol]] (THC), the active component of [[cannabis]].


==Pharmacology==
==Pharmacology==
CUMYL-THPINACA acts as a potent [[agonist]] for the [[CB1 receptor]], with a binding affinity of 5.5 nM. This makes it approximately 33 times more potent than [[THC]], the primary psychoactive compound in cannabis. The exact mechanisms of action and metabolic pathways of CUMYL-THPINACA are not fully understood, but it is believed to act in a similar manner to other synthetic cannabinoids.
CUMYL-THPINACA acts as a potent agonist at the [[CB1 receptor|CB1]] and [[CB2 receptor|CB2]] cannabinoid receptors. These receptors are part of the [[endocannabinoid system]], which plays a role in regulating various physiological processes such as mood, memory, and pain sensation. The activation of these receptors by CUMYL-THPINACA can lead to psychoactive effects similar to those of THC.


==Effects==
==Usage and effects==
The effects of CUMYL-THPINACA can vary widely depending on the dose and individual's tolerance. Common effects include relaxation, euphoria, altered perception, and in some cases, hallucinations. However, CUMYL-THPINACA can also cause a number of adverse effects, including anxiety, paranoia, and in severe cases, seizures.
Synthetic cannabinoids like CUMYL-THPINACA are often sprayed onto plant material and sold as "herbal incense" or "spice." Users may experience effects such as euphoria, altered perception, and relaxation. However, these substances can also cause adverse effects, including anxiety, paranoia, and in some cases, severe health complications.


==Legal Status==
==Legal status==
CUMYL-THPINACA is illegal in many countries, including the United States, where it is classified as a Schedule I controlled substance. It is also illegal in many European countries, including the United Kingdom, where it is classified as a Class B drug.
The legal status of CUMYL-THPINACA varies by country. In many jurisdictions, it is classified as a controlled substance due to its potential for abuse and lack of accepted medical use. Regulatory agencies continue to monitor and update the legal status of synthetic cannabinoids as new compounds are developed and identified.


==See Also==
==Health risks==
The use of CUMYL-THPINACA and other synthetic cannabinoids has been associated with numerous health risks. These include cardiovascular problems, seizures, and acute kidney injury. The variability in potency and composition of synthetic cannabinoid products increases the risk of overdose and adverse reactions.
 
==Related pages==
* [[Synthetic cannabinoids]]
* [[Synthetic cannabinoids]]
* [[CUMYL-PINACA]]
* [[Cannabinoid receptor]]
* [[CB1 receptor]]
* [[Tetrahydrocannabinol]]
* [[THC]]
* [[Endocannabinoid system]]


[[Category:Synthetic cannabinoids]]
[[Category:Synthetic cannabinoids]]
[[Category:Designer drugs]]
[[Category:Designer drugs]]
[[Category:Cannabinoids]]
<gallery>
[[Category:Psychoactive drugs]]
File:CUMYL-THPINACA.png|CUMYL-THPINACA
 
</gallery>
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Latest revision as of 01:01, 20 February 2025

Synthetic cannabinoid


CUMYL-THPINACA
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CUMYL-THPINACA is a synthetic cannabinoid that has been used in scientific research and is often found in synthetic cannabis products. It is known for its potent agonistic activity at the cannabinoid receptors.

Chemical structure and properties[edit]

CUMYL-THPINACA is classified as an indazole-based synthetic cannabinoid. Its chemical structure includes a cumyl group attached to an indazole core, with a pentyl side chain. This structure is similar to other synthetic cannabinoids, which are designed to mimic the effects of tetrahydrocannabinol (THC), the active component of cannabis.

Pharmacology[edit]

CUMYL-THPINACA acts as a potent agonist at the CB1 and CB2 cannabinoid receptors. These receptors are part of the endocannabinoid system, which plays a role in regulating various physiological processes such as mood, memory, and pain sensation. The activation of these receptors by CUMYL-THPINACA can lead to psychoactive effects similar to those of THC.

Usage and effects[edit]

Synthetic cannabinoids like CUMYL-THPINACA are often sprayed onto plant material and sold as "herbal incense" or "spice." Users may experience effects such as euphoria, altered perception, and relaxation. However, these substances can also cause adverse effects, including anxiety, paranoia, and in some cases, severe health complications.

Legal status[edit]

The legal status of CUMYL-THPINACA varies by country. In many jurisdictions, it is classified as a controlled substance due to its potential for abuse and lack of accepted medical use. Regulatory agencies continue to monitor and update the legal status of synthetic cannabinoids as new compounds are developed and identified.

Health risks[edit]

The use of CUMYL-THPINACA and other synthetic cannabinoids has been associated with numerous health risks. These include cardiovascular problems, seizures, and acute kidney injury. The variability in potency and composition of synthetic cannabinoid products increases the risk of overdose and adverse reactions.

Related pages[edit]