Pleiotrophin

Pleiotrophin (PTN), also known as heparin-binding growth-associated molecule (HB-GAM), is a protein that in humans is encoded by the PTN gene. It is a secreted cytokine that has functions in neuronal development, angiogenesis, and tissue repair.

Function

Pleiotrophin is a growth factor with a key role in various biological processes. It is involved in the growth and development of different tissues, including the nervous system and blood vessels. It also plays a role in the process of wound healing and tissue repair.

Structure

The PTN gene is located on the short (p) arm of chromosome 7 at position 21.2. The protein encoded by this gene is a secreted cytokine that induces a variety of heparan sulfate proteoglycans and can stimulate the growth of several types of cells. This cytokine can also stimulate the proliferation of endothelial cells and promote angiogenesis.

Clinical significance

Pleiotrophin has been found to be overexpressed in a variety of cancers, including breast cancer, lung cancer, and pancreatic cancer. It is thought to promote tumor growth and angiogenesis, making it a potential target for cancer therapy.

See also

• Cytokine
• Angiogenesis
• Tissue repair

References

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External links

• PTN gene at NCBI
• Pleiotrophin at UniProt

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