CXCL9

CXCL9 is a small cytokine belonging to the CXC chemokine family that is also known as Monokine induced by gamma interferon (MIG). It is secreted by activated monocytes and neutrophils and expressed in a variety of tissues. CXCL9 functions as a chemoattractant for T cells and dendritic cells by interacting with the chemokine receptor CXCR3.

Structure

CXCL9 is a 125-amino acid protein with a four-cysteine motif common to CXC chemokines. The protein structure includes a triple-stranded antiparallel beta-sheet and a C-terminal alpha-helix.

Function

CXCL9 is secreted by cells in response to IFN-gamma, and it attracts T cells and promotes T cell adhesion and migration. It is also involved in angiostasis, a process that limits the growth of new blood vessels.

Clinical significance

CXCL9 has been associated with several diseases, including autoimmune diseases, cancer, and infectious diseases. It is often upregulated in these conditions, suggesting a role in the immune response.

See also

• Chemokine
• Cytokine
• Monocyte
• Neutrophil
• T cell
• Dendritic cell
• CXCR3
• IFN-gamma
• Angiostasis
• Autoimmune diseases
• Cancer
• Infectious diseases

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