Lampbrush chromosome: Difference between revisions
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'''Lampbrush | {{Short description|Detailed overview of lampbrush chromosomes}} | ||
'''Lampbrush chromosomes''' are a special form of [[chromosome]] found in the [[oocyte]]s of most animals, except mammals. They are characterized by their large size and distinctive appearance, which resembles a brush used for cleaning lamps, hence the name. | |||
[[ | == Structure == | ||
Lampbrush chromosomes are highly extended and transcriptionally active [[chromosome]]s. They are visible under a light microscope during the [[prophase]] of [[meiosis]] in the [[oocyte]]s of [[amphibians]], [[birds]], and some other species. The chromosomes consist of a central axis with lateral loops extending outward. These loops are sites of active [[RNA]] synthesis. | |||
The loops of lampbrush chromosomes are formed by [[chromatin]] fibers that are decondensed and extended. Each loop is a transcription unit, where [[RNA polymerase]] enzymes are actively transcribing [[DNA]] into [[RNA]]. This high level of transcription is necessary to produce the large amounts of [[RNA]] required for the development of the [[oocyte]]. | |||
== Function == | |||
The primary function of lampbrush chromosomes is to facilitate the rapid and massive production of [[RNA]] during [[oogenesis]]. The extended loops provide a large surface area for the assembly of the transcription machinery, allowing for efficient [[gene expression]]. | |||
Lampbrush chromosomes also play a role in the storage and regulation of [[mRNA]]s and other [[RNA]] molecules that are crucial for early [[embryonic development]]. The [[RNA]]s synthesized on the loops are stored in the [[oocyte]] and used after [[fertilization]] to support the initial stages of [[embryogenesis]]. | |||
== Discovery and History == | |||
Lampbrush chromosomes were first observed in the late 19th century by [[Walther Flemming]], but it was [[Oskar Hertwig]] who provided detailed descriptions and illustrations of these structures in 1906. The study of lampbrush chromosomes has contributed significantly to our understanding of [[chromosome structure]] and [[gene expression]] during [[meiosis]]. | |||
== Related pages == | |||
* [[Chromosome]] | * [[Chromosome]] | ||
* [[Meiosis]] | |||
* [[Oogenesis]] | |||
* [[RNA synthesis]] | |||
* [[Gene expression]] | * [[Gene expression]] | ||
[[Category:Chromosomes]] | |||
[[Category:Cell biology]] | |||
[[Category:Genetics]] | [[Category:Genetics]] | ||
<gallery> | |||
File:O.Hertwig1906Fig5.jpg|O. Hertwig 1906 Fig 5 | |||
</gallery> | |||
Latest revision as of 21:07, 23 February 2025
Detailed overview of lampbrush chromosomes
Lampbrush chromosomes are a special form of chromosome found in the oocytes of most animals, except mammals. They are characterized by their large size and distinctive appearance, which resembles a brush used for cleaning lamps, hence the name.
Structure[edit]
Lampbrush chromosomes are highly extended and transcriptionally active chromosomes. They are visible under a light microscope during the prophase of meiosis in the oocytes of amphibians, birds, and some other species. The chromosomes consist of a central axis with lateral loops extending outward. These loops are sites of active RNA synthesis.
The loops of lampbrush chromosomes are formed by chromatin fibers that are decondensed and extended. Each loop is a transcription unit, where RNA polymerase enzymes are actively transcribing DNA into RNA. This high level of transcription is necessary to produce the large amounts of RNA required for the development of the oocyte.
Function[edit]
The primary function of lampbrush chromosomes is to facilitate the rapid and massive production of RNA during oogenesis. The extended loops provide a large surface area for the assembly of the transcription machinery, allowing for efficient gene expression.
Lampbrush chromosomes also play a role in the storage and regulation of mRNAs and other RNA molecules that are crucial for early embryonic development. The RNAs synthesized on the loops are stored in the oocyte and used after fertilization to support the initial stages of embryogenesis.
Discovery and History[edit]
Lampbrush chromosomes were first observed in the late 19th century by Walther Flemming, but it was Oskar Hertwig who provided detailed descriptions and illustrations of these structures in 1906. The study of lampbrush chromosomes has contributed significantly to our understanding of chromosome structure and gene expression during meiosis.
Related pages[edit]
-
O. Hertwig 1906 Fig 5
