Iodoform

Iodoform is a chemical compound with the formula CHI3. A pale yellow, crystalline, volatile substance, it has a penetrating and distinctive odor (in older chemistry texts, the smell is often referred to as the smell of hospitals) and, analogous to chloroform, sweetish taste. It is occasionally used as a disinfectant.

History

Iodoform was first discovered in 1822 by Serullas. The reaction leading to its formation, the iodoform reaction, was used for many years as a test for methyl ketones.

Preparation

Iodoform can be synthesized by the haloform reaction using acetone and iodine, in the presence of a base. Iodoform can also be made by the electrophilic halogenation of acetone with iodine and sodium hydroxide.

Uses

Historically, iodoform was used in medicine as a healing and antiseptic dressing for wounds and sores. This application was developed by Auguste André Thomas Cahours and Charles-Adolphe Wurtz. It was also used in hospitals for the treatment of wounds and bedsores. Today, it is used primarily in dentistry, as a filling for root canals.

Safety

Iodoform is toxic if ingested and can cause irritation if it comes into contact with the skin or eyes. It is also a potential occupational carcinogen.

See also

• Haloform reaction
• Iodine
• Acetone

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