Danazol

Danazol is a synthetic steroid that is used primarily in the treatment of endometriosis. It was approved by the FDA in 1976.

Mechanism of Action

Danazol works by decreasing the level of hormones produced by the ovaries. These hormones are involved in the menstrual cycle and can stimulate the growth of abnormal tissue in the uterus. By reducing the production of these hormones, danazol can help to shrink the abnormal tissue and relieve the symptoms of endometriosis.

Uses

Danazol is used to treat endometriosis, a condition in which the type of tissue that lines the uterus (endometrium) grows in other areas of the body and causes pain, heavy or irregular menstruation, and other symptoms. Danazol is also used to treat fibrocystic breast disease (lumpy breasts) and hereditary angioedema (a condition that causes swelling of the face, hands, feet, and throat). Danazol is in a class of medications called androgenic hormones. It works by decreasing the amount of certain hormones made by the ovaries.

Side Effects

Common side effects of danazol include weight gain, acne, and changes in menstrual cycle. More serious side effects can include liver problems, increased pressure in the brain, and blood clots.

Precautions

Before taking danazol, patients should inform their healthcare provider if they have liver disease, heart disease, kidney disease, or a history of stroke or blood clots. Danazol can interact with other medications, so patients should provide a list of all the medicines they are taking to their healthcare provider.

Dosage

The dosage of danazol depends on the condition being treated and the patient's response to therapy. It is usually taken by mouth twice a day.

See Also

• Endometriosis
• Fibrocystic Breast Disease
• Hereditary Angioedema

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Danazol

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  Chemical structure of Danazol
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  Ball-and-stick model of Danazol molecule