Nonsteroidal antiandrogen: Difference between revisions
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{{DISPLAYTITLE:Nonsteroidal Antiandrogen}} | |||
== | == Overview == | ||
Nonsteroidal antiandrogens | [[File:Bicalutamide.svg|thumb|right|Chemical structure of Bicalutamide]] | ||
Nonsteroidal antiandrogens (NSAAs) are a class of drugs that act as antagonists to the [[androgen receptor]] (AR). They are primarily used in the treatment of [[prostate cancer]], a disease that is often driven by [[androgen]]s such as [[testosterone]] and [[dihydrotestosterone]] (DHT). | |||
== | == Mechanism of Action == | ||
NSAAs work by binding to the androgen receptor, thereby preventing androgens from binding and activating the receptor. This inhibition of androgen receptor activation leads to a decrease in the growth of androgen-dependent tissues, such as the prostate gland. | |||
== | == Clinical Uses == | ||
NSAAs are mainly used in the treatment of prostate cancer. They are often used in combination with other therapies, such as [[gonadotropin-releasing hormone]] (GnRH) analogs, to achieve maximal androgen blockade. This combination is known as [[combined androgen blockade]] (CAB). | |||
== | == Bicalutamide == | ||
Bicalutamide is one of the most commonly used NSAAs. It is often prescribed as part of the treatment regimen for prostate cancer. Bicalutamide is usually administered orally and is well-tolerated by most patients. | |||
== | === Pharmacokinetics === | ||
Bicalutamide is absorbed from the gastrointestinal tract and has a long half-life, allowing for once-daily dosing. It is metabolized in the liver and excreted primarily in the urine. | |||
=== Side Effects === | |||
Common side effects of bicalutamide include hot flashes, gynecomastia, and gastrointestinal disturbances. Long-term use may also lead to liver function abnormalities, which necessitates regular monitoring of liver enzymes. | |||
== Related Pages == | |||
* [[Androgen receptor]] | * [[Androgen receptor]] | ||
* [[Prostate cancer]] | |||
* [[Testosterone]] | |||
* [[Dihydrotestosterone]] | |||
* [[Gonadotropin-releasing hormone]] | |||
[[Category: | [[Category:Antiandrogens]] | ||
[[Category: | [[Category:Hormonal antineoplastic drugs]] | ||
Latest revision as of 06:02, 16 February 2025
Overview[edit]
Nonsteroidal antiandrogens (NSAAs) are a class of drugs that act as antagonists to the androgen receptor (AR). They are primarily used in the treatment of prostate cancer, a disease that is often driven by androgens such as testosterone and dihydrotestosterone (DHT).
Mechanism of Action[edit]
NSAAs work by binding to the androgen receptor, thereby preventing androgens from binding and activating the receptor. This inhibition of androgen receptor activation leads to a decrease in the growth of androgen-dependent tissues, such as the prostate gland.
Clinical Uses[edit]
NSAAs are mainly used in the treatment of prostate cancer. They are often used in combination with other therapies, such as gonadotropin-releasing hormone (GnRH) analogs, to achieve maximal androgen blockade. This combination is known as combined androgen blockade (CAB).
Bicalutamide[edit]
Bicalutamide is one of the most commonly used NSAAs. It is often prescribed as part of the treatment regimen for prostate cancer. Bicalutamide is usually administered orally and is well-tolerated by most patients.
Pharmacokinetics[edit]
Bicalutamide is absorbed from the gastrointestinal tract and has a long half-life, allowing for once-daily dosing. It is metabolized in the liver and excreted primarily in the urine.
Side Effects[edit]
Common side effects of bicalutamide include hot flashes, gynecomastia, and gastrointestinal disturbances. Long-term use may also lead to liver function abnormalities, which necessitates regular monitoring of liver enzymes.
