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== '''What is Trifarotene?''' ==
== Trifarotene ==
* Trifarotene ('''AKLIEF''') Cream is a [[retinoid]] used for the [[topical]] treatment of [[acne vulgaris]].
[[File:Trifarotene.svg|thumb|right|Chemical structure of Trifarotene]]
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'''Trifarotene''' is a [[retinoid]] medication primarily used in the treatment of [[acne vulgaris]]. It is notable for its selective action on the [[retinoic acid receptor]] (RAR) gamma, which is the most common RAR found in the skin. This selectivity is believed to contribute to its efficacy and tolerability in treating acne.
* AKLIEF Cream is a [[retinoid]] indicated for the [[topical]] treatment of [[acne vulgaris]] in patients 9 years of age and older.
Trifarotene works by binding to the RAR gamma, which is a type of nuclear receptor. This binding modulates the expression of genes involved in cell differentiation and proliferation. By influencing these processes, trifarotene helps to normalize the shedding of dead skin cells, reduce inflammation, and decrease the formation of comedones, which are the primary lesions in acne.
== '''How does this medicine work?''' ==
== Clinical Use ==
* Trifarotene is an '''[[agonist]] of retinoic acid receptors (RAR), with particular activity at the gamma subtype of RAR'''.
Trifarotene is available as a topical cream and is applied directly to the skin. It is indicated for the treatment of facial and truncal acne in patients aged 9 years and older. The cream is typically applied once daily in the evening to the affected areas after cleansing.
* Stimulation of RAR results in modulation of target genes which are associated with various processes, including cell differentiation and mediation of inflammation.
* The exact process by which trifarotene ameliorates acne is unknown.
== '''Who Should Not Use this medicine ?''' ==
== Side Effects ==
* This medicine have no usage limitations.
Common side effects of trifarotene include skin irritation, dryness, and redness at the site of application. These effects are generally mild to moderate and tend to decrease with continued use. Patients are advised to use a moisturizer to help manage dryness and irritation.
== '''What drug interactions can this medicine cause?''' ==
== Advantages ==
* AKLIEF Cream is not expected to affect the circulating concentrations of oral hormonal [[contraceptives]] containing [[ethinyl estradiol]] and [[levonorgestrel]].
One of the main advantages of trifarotene over other retinoids is its selective action on RAR gamma, which may result in fewer side effects and better tolerability. Additionally, its efficacy in treating both facial and truncal acne makes it a versatile option for patients with widespread acne.
== '''Is this medicine FDA approved?''' ==
== Related Pages ==
* It was approved for use in the United States in 2019.
* [[Acne vulgaris]]
* [[Retinoid]]
== '''How should this medicine be used?''' ==
* [[Retinoic acid receptor]]
'''Administration'''
* Apply a thin layer of AKLIEF Cream to the affected areas once daily, in the evening, on clean and dry skin.
* One pump actuation should be enough to cover the face (i.e., forehead, cheeks, nose, and chin).
* Two actuations of the pump should be enough to cover the upper trunk (i.e., reachable upper back, shoulders and chest). One additional pump actuation may be used for middle and lower back if acne is present.
* The use of a moisturizer is recommended as frequently as needed from the initiation of treatment.
* Avoid contact with the eyes, lips, paranasal creases, mucous membranes.
* AKLIEF Cream is for topical use only. Not for oral, ophthalmic, or intravaginal use.
== '''What are the dosage forms and brand names of this medicine?''' ==
This medicine is available in fallowing doasage form:
* '''As Cream:''' 0.005% trifarotene
This medicine is available in fallowing brand namesː
*'''AKLIEF'''
=='''What side effects can this medication cause?'''==
The most common side effects of this medicine include:
* site irritation
* application site [[pruritus]]
* sunburn
==''' What special precautions should I follow?''' =
* Patients using AKLIEF Cream may experience erythema, scaling, dryness, and stinging/burning.
* Use a moisturizer from the initiation of treatment, and, if appropriate, reduce the frequency of application of AKLIEF Cream, suspend or discontinue use.
* Avoid application of AKLIEF Cream to cuts, abrasions, or eczematous or sunburned skin. Use of “waxing” as a depilatory method should be avoided on skin treated with AKLIEF Cream.
* Minimize unprotected exposure to ultraviolet rays (including sunlight and sunlamps) during treatment with AKLIEF Cream. Use sunscreen and protective clothing over treated areas when exposure cannot be avoided.
== '''What to do in case of emergency/overdose?''' ==
* {{overdose}}
== '''Can this medicine be used in pregnancy?''' ==
* Available data from clinical trials with AKLIEF Cream use in pregnant women have not identified a drug-associated risk of major birth defects, miscarriage or adverse maternal or fetal outcomes.
=='''Can this medicine be used in children?'''==
* Safety and effectiveness of AKLIEF Cream for the topical treatment of acne vulgaris have been established in pediatric patients age 9 years to 17 years.
* Safety and effectiveness of AKLIEF Cream have not been established in pediatric subjects under the age of 9 years.
== '''What are the active and inactive ingredients in this medicine?''' ==
'''Active ingredient: '''
* Trifarotene
'''Inactive ingredients:'''
* Allantoin
* Acrylic Acid/Sodium Acrylate Copolymer
* Isohexadecane
* Cyclomethicone 5
* Alcohol
* Medium-Chain Triglycerides
* Phenoxyethanol
* Propylene Glycol
* Water
== '''Who manufactures and distributes this medicine?''' ==
* Packager: Galderma Laboratories, L.P.
== '''What should I know about storage and disposal of this medication?''' ==
* Store at 20 to 25˚C (68 to 77˚F) with excursions permitted to 15°to 30°C (59° to 86°F).
Trifarotene is a retinoid medication primarily used in the treatment of acne vulgaris. It is notable for its selective action on the retinoic acid receptor (RAR) gamma, which is the most common RAR found in the skin. This selectivity is believed to contribute to its efficacy and tolerability in treating acne.
Trifarotene works by binding to the RAR gamma, which is a type of nuclear receptor. This binding modulates the expression of genes involved in cell differentiation and proliferation. By influencing these processes, trifarotene helps to normalize the shedding of dead skin cells, reduce inflammation, and decrease the formation of comedones, which are the primary lesions in acne.
Trifarotene is available as a topical cream and is applied directly to the skin. It is indicated for the treatment of facial and truncal acne in patients aged 9 years and older. The cream is typically applied once daily in the evening to the affected areas after cleansing.
Common side effects of trifarotene include skin irritation, dryness, and redness at the site of application. These effects are generally mild to moderate and tend to decrease with continued use. Patients are advised to use a moisturizer to help manage dryness and irritation.
One of the main advantages of trifarotene over other retinoids is its selective action on RAR gamma, which may result in fewer side effects and better tolerability. Additionally, its efficacy in treating both facial and truncal acne makes it a versatile option for patients with widespread acne.
