Non-ossifying fibroma: Difference between revisions
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{{Short description|A benign bone tumor}} | {{Short description|A benign bone tumor}} | ||
'''Non-ossifying fibroma''' (NOF) is a benign [[bone tumor]] that typically occurs in the [[metaphysis]] of long bones in children and adolescents. It is one of the most common benign bone lesions and is often discovered incidentally on [[X-ray]]s taken for other reasons. | '''Non-ossifying fibroma''' (NOF) is a benign [[bone tumor]] that typically occurs in the [[metaphysis]] of long bones in children and adolescents. It is one of the most common benign bone lesions and is often discovered incidentally on [[X-ray]]s taken for other reasons. | ||
==Pathophysiology== | ==Pathophysiology== | ||
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| Non-ossifying fibroma | |
|---|---|
| |
| Synonyms | Metaphyseal fibrous defect, fibrous cortical defect |
| Pronounce | N/A |
| Specialty | N/A |
| Symptoms | Usually asymptomatic, may cause pain or fracture if large |
| Complications | Pathological fracture |
| Onset | Typically in children and adolescents |
| Duration | Often resolves spontaneously |
| Types | N/A |
| Causes | Unknown, possibly developmental |
| Risks | None known |
| Diagnosis | X-ray, CT scan, MRI |
| Differential diagnosis | Fibrous dysplasia, Osteosarcoma, Chondromyxoid fibroma |
| Prevention | N/A |
| Treatment | Observation, surgical curettage if symptomatic |
| Medication | N/A |
| Prognosis | Excellent, often resolves without treatment |
| Frequency | Common in children, especially males |
| Deaths | N/A |
A benign bone tumor
Non-ossifying fibroma (NOF) is a benign bone tumor that typically occurs in the metaphysis of long bones in children and adolescents. It is one of the most common benign bone lesions and is often discovered incidentally on X-rays taken for other reasons.
Pathophysiology[edit]
Non-ossifying fibromas are composed of fibrous tissue and are considered a type of fibrous cortical defect. They are characterized by a proliferation of spindle-shaped fibroblasts and histiocytes, often with scattered multinucleated giant cells. The lesion is typically well-circumscribed and located in the cortex of the bone.
Clinical Presentation[edit]
Most non-ossifying fibromas are asymptomatic and are found incidentally. However, larger lesions may cause pain or pathological fractures, especially if they weaken the structural integrity of the bone.
Diagnosis[edit]
Diagnosis is primarily made through imaging studies. On X-ray, non-ossifying fibromas appear as well-defined, eccentric, lytic lesions with a sclerotic margin. They are often located in the metaphysis of long bones such as the femur or tibia. Advanced imaging techniques such as CT scan or MRI can be used to further characterize the lesion. On CT, a mature non-ossifying fibroma may show a well-defined, cortically based lesion with a sclerotic rim.
Treatment[edit]
In most cases, non-ossifying fibromas do not require treatment and are monitored with periodic imaging. If the lesion is large or symptomatic, surgical intervention may be necessary. This can include curettage and bone grafting to stabilize the bone and prevent fracture.
Prognosis[edit]
The prognosis for non-ossifying fibroma is excellent. These lesions often spontaneously regress as the child grows, and they rarely cause long-term complications. Malignant transformation is extremely rare.
