Fibrolamellar hepatocellular carcinoma: Difference between revisions
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{{SI}} | |||
{{Infobox medical condition | |||
| name = Fibrolamellar hepatocellular carcinoma | |||
| image = [[File:Fibrolamellar_hepatocellular_carcinoma_-2-_very_high_mag.jpg|alt=Micrograph of fibrolamellar hepatocellular carcinoma]] | |||
| caption = Micrograph of fibrolamellar hepatocellular carcinoma | |||
| field = [[Oncology]] | |||
| symptoms = [[Abdominal pain]], [[weight loss]], [[jaundice]], [[nausea]] | |||
| complications = [[Metastasis]], [[liver failure]] | |||
| onset = Typically in [[adolescents]] and [[young adults]] | |||
| duration = Chronic | |||
| types = Primary liver cancer | |||
| causes = Unknown | |||
| risks = No known risk factors | |||
| diagnosis = [[Imaging studies]], [[biopsy]] | |||
| differential = [[Hepatocellular carcinoma]], [[cholangiocarcinoma]] | |||
| prevention = None | |||
| treatment = [[Surgical resection]], [[chemotherapy]], [[liver transplantation]] | |||
| medication = [[Chemotherapy drugs]] | |||
| prognosis = Variable, generally better than conventional [[hepatocellular carcinoma]] | |||
| frequency = Rare | |||
}} | |||
[[File:Fibrolamellar_hepatocellular_carcinoma_-2-_high_mag.jpg|Fibrolamellar hepatocellular carcinoma - High magnification|thumb|left]] | |||
'''Fibrolamellar Hepatocellular Carcinoma''' ('''FL-HCC''') is a rare form of [[liver cancer]] that typically affects adolescents and young adults who do not have a history of liver disease. | '''Fibrolamellar Hepatocellular Carcinoma''' ('''FL-HCC''') is a rare form of [[liver cancer]] that typically affects adolescents and young adults who do not have a history of liver disease. | ||
==Epidemiology== | ==Epidemiology== | ||
FL-HCC accounts for a small percentage of all [[Hepatocellular carcinoma|HCC]] cases. It is more common in young adults and has no significant gender predilection. Unlike most forms of HCC, FL-HCC is not associated with chronic liver disease or cirrhosis. | FL-HCC accounts for a small percentage of all [[Hepatocellular carcinoma|HCC]] cases. It is more common in young adults and has no significant gender predilection. Unlike most forms of HCC, FL-HCC is not associated with chronic liver disease or cirrhosis. | ||
==Pathophysiology== | ==Pathophysiology== | ||
The pathophysiology of FL-HCC is not fully understood. It is known that the tumor cells in FL-HCC are characterized by large, pale eosinophilic cytoplasm and prominent nucleoli. The tumor cells are arranged in cords that are separated by fibrous bands, giving the tumor its characteristic "fibrolamellar" appearance. | The pathophysiology of FL-HCC is not fully understood. It is known that the tumor cells in FL-HCC are characterized by large, pale eosinophilic cytoplasm and prominent nucleoli. The tumor cells are arranged in cords that are separated by fibrous bands, giving the tumor its characteristic "fibrolamellar" appearance. | ||
==Clinical Presentation== | ==Clinical Presentation== | ||
Patients with FL-HCC often present with nonspecific symptoms such as weight loss, abdominal pain, and a palpable mass in the abdomen. Some patients may also present with jaundice. | Patients with FL-HCC often present with nonspecific symptoms such as weight loss, abdominal pain, and a palpable mass in the abdomen. Some patients may also present with jaundice. | ||
==Diagnosis== | ==Diagnosis== | ||
The diagnosis of FL-HCC is typically made based on imaging studies such as [[Computed tomography|CT]] or [[Magnetic resonance imaging|MRI]], and confirmed by liver biopsy. The tumor often appears as a large, solitary mass with a central scar on imaging studies. | The diagnosis of FL-HCC is typically made based on imaging studies such as [[Computed tomography|CT]] or [[Magnetic resonance imaging|MRI]], and confirmed by liver biopsy. The tumor often appears as a large, solitary mass with a central scar on imaging studies. | ||
==Treatment== | ==Treatment== | ||
The mainstay of treatment for FL-HCC is surgical resection, which can be curative if the tumor is localized. For patients with advanced disease, chemotherapy and targeted therapies may be used. | The mainstay of treatment for FL-HCC is surgical resection, which can be curative if the tumor is localized. For patients with advanced disease, chemotherapy and targeted therapies may be used. | ||
==Prognosis== | ==Prognosis== | ||
The prognosis of FL-HCC is generally better than that of other forms of HCC, with a 5-year survival rate of approximately 50-70%. However, the prognosis can vary widely depending on the stage of the disease at diagnosis and the patient's overall health. | The prognosis of FL-HCC is generally better than that of other forms of HCC, with a 5-year survival rate of approximately 50-70%. However, the prognosis can vary widely depending on the stage of the disease at diagnosis and the patient's overall health. | ||
==See Also== | ==See Also== | ||
* [[Hepatocellular carcinoma]] | * [[Hepatocellular carcinoma]] | ||
| Line 24: | Line 39: | ||
* [[Computed tomography]] | * [[Computed tomography]] | ||
* [[Magnetic resonance imaging]] | * [[Magnetic resonance imaging]] | ||
[[Category:Cancer]] | [[Category:Cancer]] | ||
[[Category:Liver diseases]] | [[Category:Liver diseases]] | ||
[[Category:Rare diseases]] | [[Category:Rare diseases]] | ||
{{Medicine-stub}} | {{Medicine-stub}} | ||
Latest revision as of 16:16, 6 April 2025
Editor-In-Chief: Prab R Tumpati, MD
Obesity, Sleep & Internal medicine
Founder, WikiMD Wellnesspedia &
W8MD medical weight loss NYC and sleep center NYC
| Fibrolamellar hepatocellular carcinoma | |
|---|---|
| |
| Synonyms | N/A |
| Pronounce | N/A |
| Specialty | N/A |
| Symptoms | Abdominal pain, weight loss, jaundice, nausea |
| Complications | Metastasis, liver failure |
| Onset | Typically in adolescents and young adults |
| Duration | Chronic |
| Types | Primary liver cancer |
| Causes | Unknown |
| Risks | No known risk factors |
| Diagnosis | Imaging studies, biopsy |
| Differential diagnosis | Hepatocellular carcinoma, cholangiocarcinoma |
| Prevention | None |
| Treatment | Surgical resection, chemotherapy, liver transplantation |
| Medication | Chemotherapy drugs |
| Prognosis | Variable, generally better than conventional hepatocellular carcinoma |
| Frequency | Rare |
| Deaths | N/A |
Fibrolamellar Hepatocellular Carcinoma (FL-HCC) is a rare form of liver cancer that typically affects adolescents and young adults who do not have a history of liver disease.
Epidemiology[edit]
FL-HCC accounts for a small percentage of all HCC cases. It is more common in young adults and has no significant gender predilection. Unlike most forms of HCC, FL-HCC is not associated with chronic liver disease or cirrhosis.
Pathophysiology[edit]
The pathophysiology of FL-HCC is not fully understood. It is known that the tumor cells in FL-HCC are characterized by large, pale eosinophilic cytoplasm and prominent nucleoli. The tumor cells are arranged in cords that are separated by fibrous bands, giving the tumor its characteristic "fibrolamellar" appearance.
Clinical Presentation[edit]
Patients with FL-HCC often present with nonspecific symptoms such as weight loss, abdominal pain, and a palpable mass in the abdomen. Some patients may also present with jaundice.
Diagnosis[edit]
The diagnosis of FL-HCC is typically made based on imaging studies such as CT or MRI, and confirmed by liver biopsy. The tumor often appears as a large, solitary mass with a central scar on imaging studies.
Treatment[edit]
The mainstay of treatment for FL-HCC is surgical resection, which can be curative if the tumor is localized. For patients with advanced disease, chemotherapy and targeted therapies may be used.
Prognosis[edit]
The prognosis of FL-HCC is generally better than that of other forms of HCC, with a 5-year survival rate of approximately 50-70%. However, the prognosis can vary widely depending on the stage of the disease at diagnosis and the patient's overall health.
See Also[edit]
