Mesterolone: Difference between revisions

Latest revision as of 10:48, 23 March 2025

Mesterolone[edit]

Mesterolone is an androgen and anabolic steroid (AAS) medication which is used mainly in the treatment of low testosterone levels. It is also used to treat male infertility, although this use is controversial. Mesterolone is marketed under the brand name Proviron among others. It is taken by mouth.

Mesterolone was first described in 1934 and was introduced for medical use in 1937. It is one of the oldest AAS and was widely used in the past, although it is now less commonly used. Mesterolone is available in many countries, including the United Kingdom, Australia, and South Africa, but it is not available in the United States.

Medical Uses[edit]

Mesterolone is used in the treatment of hypogonadism in men, a condition characterized by low levels of testosterone. It is also used to treat male infertility, although its effectiveness for this purpose is not well established. Mesterolone is sometimes used by bodybuilders and athletes to improve physique and performance, although such use is not recommended due to potential health risks.

Pharmacology[edit]

Pharmacodynamics[edit]

Mesterolone is a synthetic androgen and anabolic steroid and hence is an agonist of the androgen receptor, the biological target of androgens like testosterone and dihydrotestosterone (DHT). It is a derivative of DHT and is similar to it in its effects, but unlike testosterone, mesterolone is not aromatized into estrogens and hence has no risk of estrogenic side effects such as gynecomastia.

Pharmacokinetics[edit]

Mesterolone is well-absorbed orally, unlike testosterone, which is rapidly broken down in the liver when taken by mouth. It has a high affinity for sex hormone-binding globulin (SHBG), which may displace other steroids from SHBG, increasing their free concentrations in the blood.

Side Effects[edit]

The side effects of mesterolone are similar to those of other AAS. They include acne, increased hair growth, voice changes, and increased sexual desire. Mesterolone does not cause liver damage and has little or no effect on the liver enzymes.

Chemistry[edit]

Mesterolone, also known as 1α-methyl-4,5α-dihydrotestosterone (1α-methyl-DHT) or as 1α-methyl-5α-androstan-17β-ol-3-one, is a synthetic androstane steroid and a derivative of DHT. It is specifically DHT with a methyl group at the C1α position.

History[edit]

Mesterolone was first described in 1934 and was introduced for medical use in 1937. It was developed by Schering and has been marketed under the brand name Proviron among others. Mesterolone was one of the first AAS to be synthesized and used in medicine.

Society and Culture[edit]

Generic Names[edit]

Mesterolone is the generic name of the drug and its INN, USAN, BAN, and JAN. It is also known by its developmental code name SH-958.

Brand Names[edit]

Mesterolone is marketed under a variety of brand names, including Proviron, Mestoranum, and others.

Availability[edit]

Mesterolone is available in many countries around the world, including the United Kingdom, Australia, and South Africa. However, it is not available in the United States.

Related Pages[edit]

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-'''Mesterolone''' is an [[androgen]] and [[anabolic steroid]] (AAS) medication which is used mainly in the treatment of low [[testosterone]] levels in men. It has also been used to treat male [[infertility]], although this use is controversial. Mesterolone is taken by mouth.
+== Mesterolone ==
-==Medical Uses==
+[[File:Mesterolone.svg|Chemical structure of Mesterolone|thumb|right]]
-Mesterolone is used primarily in the treatment of low testosterone levels in men. Low testosterone can manifest in a variety of symptoms including decreased libido, fatigue, decreased muscle mass, and increased body fat. Mesterolone, by acting as a substitute for natural testosterone, can help alleviate these symptoms. Additionally, it has been used in the treatment of male infertility, particularly in cases where the infertility is due to low levels of testosterone.
-==Pharmacology==
+'''Mesterolone''' is an [[androgen]] and [[anabolic steroid]] (AAS) medication which is used mainly in the treatment of low testosterone levels. It is also used to treat male infertility, although this use is controversial. Mesterolone is marketed under the brand name Proviron among others. It is taken by mouth.
-===Mechanism of Action===
-Mesterolone is a synthetic derivative of [[dihydrotestosterone]] (DHT), which is a naturally occurring form of testosterone. It works by binding to androgen receptors in the body, which are found in various tissues including muscles, hair follicles, and the reproductive organs. This binding initiates a series of events that result in the expression of specific genes that are responsible for the development and maintenance of male characteristics and reproductive function.
-===Pharmacokinetics===
+Mesterolone was first described in 1934 and was introduced for medical use in 1937. It is one of the oldest AAS and was widely used in the past, although it is now less commonly used. Mesterolone is available in many countries, including the United Kingdom, Australia, and South Africa, but it is not available in the United States.
-The pharmacokinetics of mesterolone are characterized by its oral route of administration. It is well absorbed from the gastrointestinal tract, but it undergoes significant first-pass metabolism in the liver, which reduces its bioavailability. Mesterolone is highly bound to plasma proteins and is metabolized in the liver. Its metabolites are excreted in the urine and feces.
-==Adverse Effects==
+== Medical Uses ==
-The use of mesterolone, like other androgenic steroids, can lead to adverse effects. These can include:
-- Acne
-- Hair loss
-- Voice changes
-- Growth of body hair
-- Increase in red blood cells, which can lead to complications such as blood clots
-- Liver damage, though this is less common with mesterolone compared to other oral steroids due to its chemical structure
-It is important for individuals taking mesterolone to be monitored by a healthcare provider to manage and mitigate these potential side effects.
+Mesterolone is used in the treatment of [[hypogonadism]] in men, a condition characterized by low levels of testosterone. It is also used to treat male infertility, although its effectiveness for this purpose is not well established. Mesterolone is sometimes used by bodybuilders and athletes to improve physique and performance, although such use is not recommended due to potential health risks.
-==Contraindications==
+== Pharmacology ==
-Mesterolone should not be used in individuals with known hypersensitivity to the drug or any of its components. It is also contraindicated in patients with prostate cancer, as androgens can accelerate the growth of prostate tumors. Additionally, it should not be used in pregnant or breastfeeding women due to the potential for virilization of the female fetus or infant.
-==Interactions==
+=== Pharmacodynamics ===
-Mesterolone can interact with other medications, particularly those that are metabolized by the liver. It can affect the metabolism of other drugs, leading to altered levels of these medications in the body. Patients should inform their healthcare provider of all medications they are taking to avoid potential drug interactions.
-==See Also==
+Mesterolone is a synthetic [[androgen]] and [[anabolic steroid]] and hence is an agonist of the [[androgen receptor]], the biological target of androgens like [[testosterone]] and [[dihydrotestosterone]] (DHT). It is a derivative of DHT and is similar to it in its effects, but unlike testosterone, mesterolone is not aromatized into [[estrogens]] and hence has no risk of estrogenic side effects such as [[gynecomastia]].
+=== Pharmacokinetics ===
+Mesterolone is well-absorbed orally, unlike testosterone, which is rapidly broken down in the liver when taken by mouth. It has a high affinity for [[sex hormone-binding globulin]] (SHBG), which may displace other steroids from SHBG, increasing their free concentrations in the blood.
+== Side Effects ==
+The side effects of mesterolone are similar to those of other AAS. They include [[acne]], increased hair growth, voice changes, and increased sexual desire. Mesterolone does not cause liver damage and has little or no effect on the [[liver enzymes]].
+== Chemistry ==
+Mesterolone, also known as 1α-methyl-4,5α-dihydrotestosterone (1α-methyl-DHT) or as 1α-methyl-5α-androstan-17β-ol-3-one, is a synthetic androstane steroid and a derivative of DHT. It is specifically DHT with a methyl group at the C1α position.
+== History ==
+Mesterolone was first described in 1934 and was introduced for medical use in 1937. It was developed by Schering and has been marketed under the brand name Proviron among others. Mesterolone was one of the first AAS to be synthesized and used in medicine.
+== Society and Culture ==
+=== Generic Names ===
+Mesterolone is the generic name of the drug and its INN, USAN, BAN, and JAN. It is also known by its developmental code name SH-958.
+=== Brand Names ===
+Mesterolone is marketed under a variety of brand names, including Proviron, Mestoranum, and others.
+=== Availability ===
+Mesterolone is available in many countries around the world, including the United Kingdom, Australia, and South Africa. However, it is not available in the United States.
+== Related Pages ==
+* [[Androgen]]
+* [[Anabolic steroid]]
+* [[Hypogonadism]]
 * [[Testosterone]]
-* [[Anabolic steroid]]
 * [[Dihydrotestosterone]]
-* [[Male infertility]]
 [[Category:Androgens and anabolic steroids]]
-[[Category:World Anti-Doping Agency prohibited substances]]
+[[Category:Androstanes]]
-[[Category:Medications used in men's health]]
+[[Category:Schering AG brands]]
-{{medicine-stub}}
-<gallery>
-File:Mesterolone.svg|Mesterolone
-</gallery>
-<gallery>
-File:Mesterolone.svg|Mesterolone
-</gallery>