Rabbit syndrome: Difference between revisions

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'''Rabbit syndrome''' is a rare<ref name="PMID 2870650">{{cite journal |pmid=2870650 |year=1986 |last1=Yassa |first1=R |title=Prevalence of the rabbit syndrome |journal=American Journal of Psychiatry |volume=143 |issue=5 |pages=656–7 |last2=Lal |first2=S |doi=10.1176/ajp.143.5.656 }}</ref> form of [[extrapyramidal symptoms|extrapyramidal]] side effect of [[antipsychotic]] drugs in which [[wikt:perioral|perioral]] tremors occur at a rate of approximately 5&nbsp;Hz. Rabbit syndrome is characterized by involuntary, fine, rhythmic motions of the mouth along a vertical plane, without involvement of the tongue,<ref name="PMID 5042912">{{cite journal |pmid=5042912 |year=1972 |last1=Villeneuve |first1=A |title=The rabbit syndrome. A peculiar extrapyramidal reaction |journal=Canadian Psychiatric Association Journal |volume=17 |issue=2 |pages=Suppl 2:SS69– |doi=10.1177/07067437720176S213 }}</ref><ref name="PMID 17562001">{{cite journal |doi=10.1186/1745-0179-3-6 |pmid=17562001 |pmc=1914060 |title=Newer antipsychotics and the rabbit syndrome |journal=Clinical Practice and Epidemiology in Mental Health |volume=3 |pages=6 |year=2007 |last1=Catena Dell'Osso |first1=Mario |last2=Fagiolini |first2=Andrea |last3=Ducci |first3=Francesca |last4=Masalehdan |first4=Azadeh |last5=Ciapparelli |first5=Antonio |last6=Frank |first6=Ellen }}</ref> and resembling the chewing movements of a rabbit.<ref>{{cite journal |pmid=15015902 |year=2004 |last1=Schwartz |first1=M |title=Antipsychotic-induced rabbit syndrome: Epidemiology, management and pathophysiology |journal=CNS Drugs |volume=18 |issue=4 |pages=213–20 |last2=Hocherman |first2=S |doi=10.2165/00023210-200418040-00002 }}</ref> It is usually seen after years of pharmacotherapy, and is more prominent with high potency drugs like [[haloperidol]], [[fluphenazine]], and [[pimozide]]. There is also a low incidence with [[thioridazine]], [[clozapine]], [[olanzapine]], [[aripiprazole]],<ref name="pmid18262773">{{cite journal |doi=10.1016/j.schres.2008.01.008 |pmid=18262773 |title=Aripiprazole-induced rabbit syndrome in a drug-naive schizophrenic patient |journal=Schizophrenia Research |volume=103 |issue=1–3 |pages=341–2 |year=2008 |last1=Gonidakis |first1=F |last2=Ploubidis |first2=D |last3=Papadimitriou |first3=G }}</ref> and low doses of [[risperidone]].
{{Short description|A rare movement disorder characterized by involuntary, rapid movements of the mouth}}


Rabbit syndrome can be treated with [[anticholinergic]] drugs. It generally disappears within a few days of treatment but may re-emerge after anticholinergic treatment is stopped. Another treatment strategy is to switch the patient to an atypical antipsychotic with high anti-cholinergic properties.<ref name="PMID 17562001" />
'''Rabbit syndrome''' is a rare [[movement disorder]] characterized by involuntary, rapid, rhythmic movements of the mouth, resembling the chewing motions of a rabbit. This condition is often associated with long-term use of [[antipsychotic medications]], particularly the older, typical antipsychotics.


==References==
==Presentation==
{{reflist|2}}
The primary symptom of rabbit syndrome is the repetitive, involuntary movement of the mouth and lips, which is distinct from [[tardive dyskinesia]], another movement disorder associated with antipsychotic use. Unlike tardive dyskinesia, rabbit syndrome does not typically involve the tongue or other parts of the body. The movements are usually rapid and rhythmic, resembling the chewing or twitching motions seen in rabbits.


[[Category:Neurological disorders]]
==Causes==
[[Category:Rare diseases]]
Rabbit syndrome is most commonly caused by the long-term use of [[typical antipsychotics]], such as [[haloperidol]] and [[chlorpromazine]]. These medications are known to block [[dopamine receptors]] in the brain, which can lead to various movement disorders. The exact mechanism by which these drugs cause rabbit syndrome is not fully understood, but it is believed to involve an imbalance in the [[dopaminergic pathways]] of the brain.
[[Category:Extrapyramidal and movement disorders]]
[[Category:Syndromes]]


==Diagnosis==
The diagnosis of rabbit syndrome is primarily clinical, based on the characteristic movements and the patient's medication history. It is important to differentiate rabbit syndrome from other drug-induced movement disorders, such as [[tardive dyskinesia]] and [[parkinsonism]]. A thorough neurological examination and a detailed review of the patient's medication history are essential for accurate diagnosis.


{{disease-stub}}
==Treatment==
The primary treatment for rabbit syndrome involves discontinuing or reducing the dose of the offending antipsychotic medication, if possible. In some cases, switching to an [[atypical antipsychotic]] with a lower risk of movement disorders may be beneficial. Additionally, [[anticholinergic medications]], such as [[benztropine]] or [[trihexyphenidyl]], may be used to alleviate symptoms. These medications help to restore the balance of neurotransmitters in the brain and reduce involuntary movements.
 
==Prognosis==
With appropriate treatment, the symptoms of rabbit syndrome can often be managed effectively. In many cases, reducing or discontinuing the offending medication leads to a significant improvement in symptoms. However, some patients may continue to experience mild symptoms even after treatment.
 
==Related pages==
* [[Tardive dyskinesia]]
* [[Parkinsonism]]
* [[Antipsychotic]]
* [[Dopamine receptor]]
 
[[Category:Movement disorders]]
[[Category:Extrapyramidal symptoms]]

Latest revision as of 19:24, 22 March 2025

A rare movement disorder characterized by involuntary, rapid movements of the mouth


Rabbit syndrome is a rare movement disorder characterized by involuntary, rapid, rhythmic movements of the mouth, resembling the chewing motions of a rabbit. This condition is often associated with long-term use of antipsychotic medications, particularly the older, typical antipsychotics.

Presentation[edit]

The primary symptom of rabbit syndrome is the repetitive, involuntary movement of the mouth and lips, which is distinct from tardive dyskinesia, another movement disorder associated with antipsychotic use. Unlike tardive dyskinesia, rabbit syndrome does not typically involve the tongue or other parts of the body. The movements are usually rapid and rhythmic, resembling the chewing or twitching motions seen in rabbits.

Causes[edit]

Rabbit syndrome is most commonly caused by the long-term use of typical antipsychotics, such as haloperidol and chlorpromazine. These medications are known to block dopamine receptors in the brain, which can lead to various movement disorders. The exact mechanism by which these drugs cause rabbit syndrome is not fully understood, but it is believed to involve an imbalance in the dopaminergic pathways of the brain.

Diagnosis[edit]

The diagnosis of rabbit syndrome is primarily clinical, based on the characteristic movements and the patient's medication history. It is important to differentiate rabbit syndrome from other drug-induced movement disorders, such as tardive dyskinesia and parkinsonism. A thorough neurological examination and a detailed review of the patient's medication history are essential for accurate diagnosis.

Treatment[edit]

The primary treatment for rabbit syndrome involves discontinuing or reducing the dose of the offending antipsychotic medication, if possible. In some cases, switching to an atypical antipsychotic with a lower risk of movement disorders may be beneficial. Additionally, anticholinergic medications, such as benztropine or trihexyphenidyl, may be used to alleviate symptoms. These medications help to restore the balance of neurotransmitters in the brain and reduce involuntary movements.

Prognosis[edit]

With appropriate treatment, the symptoms of rabbit syndrome can often be managed effectively. In many cases, reducing or discontinuing the offending medication leads to a significant improvement in symptoms. However, some patients may continue to experience mild symptoms even after treatment.

Related pages[edit]