Thymidylate synthase inhibitor

Thymidylate synthase inhibitor - any substance that inhibits thymidylate synthase, an enzyme that catalyzes the conversion of uridine monophosphate to thymidine monophosphate, the rate-limiting step in de novo production of dtmp. Inhibition of thymidylate synthase causes inhibition of dna synthesis and cell proloferation.

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