IFNB1

IFNB1 (Interferon Beta 1) is a protein that in humans is encoded by the IFNB1 gene. It is a type of interferon which is a group of signaling proteins made and released by host cells in response to the presence of several pathogens.

Function

Interferon Beta 1 is a cytokine in the interferon family that in humans is encoded by the IFNB1 gene. Interferons are proteins released by host cells in response to the presence of pathogens such as viruses, bacteria, parasites or tumor cells. They allow for communication between cells to trigger the protective defenses of the immune system that eradicate pathogens or tumors.

IFNB1 has antiviral, antiproliferative, and immune-modulating activities. The protein is produced by fibroblasts and lymphoblasts. IFNB1 is also used therapeutically in the treatment of multiple sclerosis.

Clinical significance

IFNB1 is used to treat the relapsing-remitting and secondary-progressive forms of multiple sclerosis. Studies have shown that regular injections of interferon beta-1a can slow the progression of physical disability and reduce the frequency of clinical attacks.

See also

• Interferon
• Multiple sclerosis

References

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External links

• GeneReviews/NCBI/NIH/UW entry on IFNB1

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