Cholecystokinin B receptor

Cholecystokinin B receptor (CCKBR) is a protein that in humans is encoded by the CCKBR gene. This receptor belongs to the G protein-coupled receptor family, specifically the subfamily of neuropeptide receptors. CCKBR is primarily found in the gastrointestinal tract and the central nervous system.

Function

The Cholecystokinin B receptor is a major physiologic mediator of pancreatic enzyme secretion and smooth muscle contraction of the gallbladder and stomach. In the central and peripheral nervous system, this receptor regulates satiety and the release of beta-endorphin and dopamine.

Clinical significance

Alterations in the CCKBR gene have been associated with panic disorder, schizophrenia, and gastrointestinal disorders. In addition, CCKBR has been implicated in several types of cancer, including gastric cancer and colorectal cancer.

Pharmacology

Several drugs target the Cholecystokinin B receptor, including proglumide and lorglumide, which are used in the treatment of gastrointestinal disorders.

See also

• Cholecystokinin A receptor
• Cholecystokinin

References

This GPCR-related article is a stub. You can help WikiMD by expanding it.

   This article is a medical stub. You can help WikiMD by expanding it!