CCL24

CCL24, also known as Eotaxin-2, is a small cytokine belonging to the CC chemokine family that is characterized by two adjacent cysteines. CCL24 interacts with chemokine receptor CCR3 to induce chemotaxis in eosinophils. This chemokine is produced by a variety of cells, including endothelial cells, fibroblasts, and macrophages. It is involved in allergic responses and has been associated with various diseases, including asthma and cancer.

Structure

CCL24 is a small protein of 119 amino acids. It is characterized by a four-cysteine motif that is common to all CC chemokines. The protein structure of CCL24 includes a triple-stranded beta-sheet and a C-terminal alpha-helix.

Function

CCL24 is a potent chemoattractant for eosinophils, basophils, and Th2 lymphocytes. It is involved in the recruitment of these cells to sites of inflammation, particularly in allergic responses. CCL24 binds to the chemokine receptor CCR3, which is primarily expressed on eosinophils, but can also be found on other immune cells, such as Th2 lymphocytes and basophils.

Clinical significance

CCL24 has been implicated in a variety of diseases. It is overexpressed in the airways of asthmatic individuals, suggesting a role in the pathogenesis of this disease. In addition, CCL24 has been associated with the progression of certain types of cancer, including breast cancer and colon cancer.

See also

• Chemokine
• Cytokine
• CCR3
• Asthma
• Cancer

References

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