Hepatitis A virus: Difference between revisions

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==Pronunciation==
#Redirect [[Hepatitis A#Virology]]
HEH-puh-TY-tis ... VY-rus
[[File:Hepatitis A virus 01.jpg|alt=Hepatitis A virus|thumb|Hepatitis A virus]]


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==Summary==
* Hepatitis A virus is a virus that causes a serious liver disease.
* It is usually spread by contact with an infected person’s stool by eating food he or she has handled after not washing hands, but it can be spread in other ways.
* Symptoms of infection include jaundice, dark urine, and fever and other flu-like symptoms.
[[File:Hepatitis.gif|alt=Hepatitis|thumb|'''Hepatitis''']]
==Definition==
* Hepatitis means [[inflammation]] of the [[liver]].
* When the liver is inflamed or damaged, its function can be affected.
* Heavy alcohol use, toxins, some medications, and certain medical conditions can cause hepatitis, but it is often caused by a virus.
* In the United States, the most common hepatitis viruses are hepatitis A virus, hepatitis B virus, and hepatitis C virus.
* Hepatitis A is a highly contagious, short-term liver infection caused by the hepatitis A virus.
* People who get hepatitis A may feel sick for a few weeks to several months but usually recover completely and do not have lasting liver damage. In rare cases, hepatitis A can cause liver failure and even death; this is more common in older people and in people with other serious health issues, such as chronic liver disease.
==Incidence==
* In 2018, there were an estimated 24,900 hepatitis A cases were reported in the United States.
* Because some people don’t ever get diagnosed, the actual number of cases reported in that year is probably closer to 24,900.
* Since 2016, person-to-person outbreaks of hepatitis A have been occurring across the United States mainly among people who use injection drugs or are experiencing homelessness, resulting in more than 32,000 cases.
==Risk factors==
* International travelers
* Men who have sex with men
* People who use injection or non-injection drugs (all those who use illegal drugs)
* People with occupational risk for exposure
* People who anticipate close personal contact with an international adoptee
* People experiencing homelessness
* People at increased risk for severe disease from HAV infection
* People with chronic liver disease
* People with human immunodeficiency virus infection
* For more information about assessing risk for hepatitis A, refer to Table 3 in Prevention of Hepatitis A Virus Infection in the United States: Recommendations of the Advisory Committee on Immunization Practices, 2020.
==Signs and symptoms==
Among older children and adults, [[infection]] is typically symptomatic.
Symptoms usually occur abruptly and can include the following:
* [[Fever]]
* [[Fatigue]]
* [[Loss of appetite]]
* [[Nausea]]
* [[Vomiting]]
* [[Abdominal pain]]
* [[Dark urine]]
* [[Diarrhea]]
* [[Clay-colored stool]]
* [[Joint pain]]
* [[Jaundice]]
Most (70%) of infections in children younger than age 6 are not accompanied by symptoms.
When symptoms are present, young children typically do not have jaundice; most (>70%) older children and adults with HAV infection have this symptom.
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==Incubation period==
* Symptoms of hepatitis A usually last less than 2 months, although 10%–15% of symptomatic persons have prolonged or relapsing disease for up to 6 months (9–13).
* The average incubation period for HAV is 28 days and ranges between 15–50 days.
==Diagnosis==
Diagnosis is with a combination of history, physical examination including travel and food history, symptoms, ordering a blood tests for hepatitis A.
==Treatment==
* To treat the symptoms of hepatitis A, rest, adequate nutrition, fluids and other supportive measures are recommended.
* Some people with severe symptoms will need medical care in a hospital.
==Vaccination==
* Vaccination with the full, two-dose series of hepatitis A vaccine is the best way to prevent infection.
* Hepatitis A vaccine has been licensed in the United States for use in people 1 year of age and older.
The following people should be vaccinated against hepatitis A:
'''Children'''
* All children aged 12–23 months
* All children and adolescents 2–18 years of age who have not previously received hepatitis A vaccine (known as “catch up” vaccination)
* People at increased risk for hepatitis A
People at increased risk for severe disease from hepatitis A infection
'''Other people recommended for vaccination'''
* Pregnant women at risk for hepatitis A or risk for severe outcome from hepatitis A infection
* Any person who requests vaccination
* How is the hepatitis A vaccine given?
* There are two types of hepatitis A vaccine.
===Vaccination schedule===
* The first type, the single-dose hepatitis A vaccine, is given as two shots, 6 months apart, and both shots are needed for long-term protection against hepatitis A.
* The other type is a combination vaccine that protects people against both hepatitis A and hepatitis B.
* The combination vaccine can be given to anyone 18 years of age and older and is given as three shots over 6 months.
* All three shots are needed for long-term protection for both hepatitis A and hepatitis B.
===Immunoglobulins===
* Immune globulin can provide short-term protection against hepatitis A, both pre- and postexposure.
* Immune globulin must be administered within 2 weeks after exposure for maximum protection.
* Given that the virus is transmitted through the fecal-oral route, good hand hygiene—including handwashing after using the bathroom, changing diapers, and before preparing or eating food—is integral to hepatitis A prevention.
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[[Category:Picornaviridae]]
[[Category:Picornaviridae]]
[[Category:Vaccine-preventable diseases]]
[[Category:Hepatitis A]]
[[Category:Hepatitis|+A]]

Latest revision as of 16:37, 28 February 2025


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