Dimethylaminopivalophenone: Difference between revisions

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{{Short description|A synthetic opioid analgesic}}
{{Short description|Chemical compound}}
{{Drugbox
{{Chembox
| verifiedfields = changed
| ImageFile = 3-(dimethylamino)-2,2-dimethyl-1-phenylpropan-1-one.svg
| verifiedrevid = 477002123
| ImageSize = 250px
| IUPAC_name = 1-(2,2-Dimethylpropyl)-4-phenylpiperidin-4-ol
| ImageAlt = Structural formula of Dimethylaminopivalophenone
| image = Dimethylaminopivalophenone_structure.png
| ImageFile1 = 3-(dimethylamino)-2,2-dimethyl-1-phenylpropan-1-one.svg
| image2 = Dimethylaminopivalophenone_3D_structure.png
| ImageSize1 = 250px
| width = 200
| ImageAlt1 = Structural formula of Dimethylaminopivalophenone
| alt = Structural formula of Dimethylaminopivalophenone
| alt2 = 3D model of Dimethylaminopivalophenone
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'''Dimethylaminopivalophenone''' is a synthetic opioid analgesic that was developed in the mid-20th century. It is chemically related to other opioids such as [[pethidine]] and [[fentanyl]]. This compound is primarily of interest in the field of medicinal chemistry and pharmacology due to its analgesic properties.
'''Dimethylaminopivalophenone''' is a chemical compound that belongs to the class of [[organic compounds]] known as [[ketones]]. It is a synthetic compound with potential applications in various fields, including [[pharmaceuticals]] and [[organic chemistry]].


==Chemical Structure and Properties==
==Chemical Structure==
Dimethylaminopivalophenone belongs to the class of piperidine derivatives. Its chemical structure is characterized by a piperidine ring, which is a common feature in many opioid analgesics. The presence of a phenyl group and a dimethylaminopropyl side chain contributes to its pharmacological activity.
Dimethylaminopivalophenone is characterized by its unique chemical structure, which includes a [[dimethylamino group]], a [[phenyl group]], and a [[ketone group]]. The presence of the dimethylamino group contributes to its basicity and potential reactivity in chemical reactions.
 
The molecular formula of Dimethylaminopivalophenone is C<sub>16</sub>H<sub>23</sub>NO, and it has a molecular weight of approximately 245.36 g/mol. The compound is typically synthesized through a series of chemical reactions involving the piperidine ring and the attachment of the phenyl and dimethylaminopropyl groups.
 
==Pharmacology==
As an opioid, Dimethylaminopivalophenone exerts its effects primarily through the [[mu-opioid receptor]]. Activation of this receptor leads to analgesia, which is the primary therapeutic effect of the drug. However, like other opioids, it can also cause side effects such as respiratory depression, sedation, and potential for addiction.
 
The potency and efficacy of Dimethylaminopivalophenone in comparison to other opioids are subjects of research. It is generally considered to be less potent than fentanyl but may have a similar profile to pethidine.
 
==Medical Use==
Dimethylaminopivalophenone is not widely used in clinical practice today, largely due to the availability of more effective and safer alternatives. However, it may still be of interest in certain research settings or in the development of new analgesic drugs.
 
==Safety and Side Effects==
The safety profile of Dimethylaminopivalophenone is similar to that of other opioids. Common side effects include nausea, vomiting, constipation, and dizziness. More serious risks involve respiratory depression, which can be life-threatening, especially in overdose situations.


==Synthesis==
==Synthesis==
The synthesis of Dimethylaminopivalophenone involves the reaction of piperidine with phenylmagnesium bromide, followed by the introduction of the dimethylaminopropyl group. This process requires careful control of reaction conditions to ensure the correct formation of the desired product.
The synthesis of dimethylaminopivalophenone typically involves the reaction of [[pivalic acid]] derivatives with [[dimethylamine]] in the presence of a suitable catalyst. The process may require specific conditions such as controlled temperature and pressure to achieve optimal yields.


==Related Compounds==
==Applications==
Dimethylaminopivalophenone is related to several other opioid analgesics, including:
Dimethylaminopivalophenone has been studied for its potential use in the development of [[pharmaceutical drugs]]. Its chemical properties make it a candidate for further research in [[medicinal chemistry]]. Additionally, it may serve as an intermediate in the synthesis of more complex organic molecules.
* [[Pethidine]]
* [[Fentanyl]]
* [[Methadone]]


These compounds share structural similarities and pharmacological properties, although they differ in potency, duration of action, and side effect profiles.
==Safety and Handling==
As with many chemical compounds, proper safety precautions should be taken when handling dimethylaminopivalophenone. It is important to use appropriate [[personal protective equipment]] and follow standard laboratory safety protocols to minimize exposure and potential hazards.


==Related Pages==
==Related pages==
* [[Opioid]]
* [[Ketone]]
* [[Analgesic]]
* [[Organic chemistry]]
* [[Piperidine]]
* [[Pharmaceutical chemistry]]
* [[Pharmacology]]


[[Category:Opioids]]
[[Category:Ketones]]
[[Category:Analgesics]]
[[Category:Organic compounds]]
[[Category:Piperidines]]

Latest revision as of 14:14, 21 February 2025

Chemical compound


Chemical Compound
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Dimethylaminopivalophenone is a chemical compound that belongs to the class of organic compounds known as ketones. It is a synthetic compound with potential applications in various fields, including pharmaceuticals and organic chemistry.

Chemical Structure[edit]

Dimethylaminopivalophenone is characterized by its unique chemical structure, which includes a dimethylamino group, a phenyl group, and a ketone group. The presence of the dimethylamino group contributes to its basicity and potential reactivity in chemical reactions.

Synthesis[edit]

The synthesis of dimethylaminopivalophenone typically involves the reaction of pivalic acid derivatives with dimethylamine in the presence of a suitable catalyst. The process may require specific conditions such as controlled temperature and pressure to achieve optimal yields.

Applications[edit]

Dimethylaminopivalophenone has been studied for its potential use in the development of pharmaceutical drugs. Its chemical properties make it a candidate for further research in medicinal chemistry. Additionally, it may serve as an intermediate in the synthesis of more complex organic molecules.

Safety and Handling[edit]

As with many chemical compounds, proper safety precautions should be taken when handling dimethylaminopivalophenone. It is important to use appropriate personal protective equipment and follow standard laboratory safety protocols to minimize exposure and potential hazards.

Related pages[edit]

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