Estradiol hemisuccinate: Difference between revisions

Estradiol hemisuccinate
INN
Drug class
Routes of administration
Pregnancy category
Bioavailability
Metabolism
Elimination half-life
Excretion
Legal status
CAS Number	123-94-4
PubChem	5282388
DrugBank	DB13945
ChemSpider	4447590
KEGG	D04078

Latest revision as of 01:42, 20 February 2025

A detailed overview of Estradiol hemisuccinate

Estradiol hemisuccinate is a synthetic estrogen and a derivative of estradiol, a naturally occurring hormone in the human body. It is used in hormone replacement therapy (HRT) and for other medical purposes. Estradiol hemisuccinate is an ester of estradiol, specifically the 3-hemisuccinate ester, which modifies the solubility and pharmacokinetics of the parent hormone.

Pharmacology[edit]

Estradiol hemisuccinate acts as an agonist of the estrogen receptor, mimicking the effects of endogenous estradiol. It is used to treat symptoms associated with menopause, such as hot flashes, vaginal atrophy, and osteoporosis. The hemisuccinate ester form allows for different routes of administration, including oral and parenteral, and can influence the duration of action of the drug.

Medical Uses[edit]

Estradiol hemisuccinate is primarily used in hormone replacement therapy for menopausal women. It helps alleviate symptoms of estrogen deficiency and can also be used in the treatment of certain types of breast cancer and prostate cancer.

Side Effects[edit]

Common side effects of estradiol hemisuccinate include nausea, headache, breast tenderness, and weight gain. Long-term use of estrogen therapy has been associated with an increased risk of breast cancer, endometrial cancer, and cardiovascular disease.

Chemistry[edit]

The chemical structure of estradiol hemisuccinate is characterized by the addition of a succinate group to the estradiol molecule. This modification increases the water solubility of the compound, which can be advantageous for certain formulations and routes of administration.

References[edit]

Estradiol hemisuccinate

@@ Line 1: / Line 1: @@
-[[Image:Estradiol.svg|thumb|right|Chemical structure of Estradiol, the parent compound of Estradiol Hemisuccinate.]]
+{{Short description|A detailed overview of Estradiol hemisuccinate}}
+{{Drugbox
+| Verifiedfields = changed
+| verifiedrevid = 477002123
+| image = Estradiol succinate.svg
+| width = 200px
+| image2 = <!-- Optional second image -->
+| width2 = <!-- Width of second image -->
+| IUPAC_name = (8R,9S,13S,14S,17S)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol 3-(hydrogen succinate)
+| CAS_number = 123-94-4
+| ATC_prefix = G03
+| ATC_suffix = CA03
+| PubChem = 5282388
+| DrugBank = DB13945
+| ChemSpiderID = 4447590
+| UNII = 4TI98Z838E
+| KEGG = D04078
+| ChEBI = 5013
+| ChEMBL = 1200488
+| C=22
+| H=28
+| O=5
+| smiles = C[C@]12CC[C@H]3[C@@H]4CCC(=O)C=C4C[C@@H]3[C@@H]1CC[C@H]2O.C(=O)(C(=O)O)CC(=O)O
+| StdInChI = 1S/C18H24O2.C4H6O4/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20;5-3(6)1-2-4(7)8/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3;1-2H2,(H,5,6)(H,7,8)/t14-,15-,16+,17+,18+;/m1./s1
+| StdInChIKey = QXHDGZCNVAXXRC-APJZJYQMSA-N
+}}
-'''Estradiol hemisuccinate''' is a chemical compound derived from estradiol, which is a natural form of estrogen. It is used in medicine as a form of hormone replacement therapy and is employed for various medical purposes.
+'''Estradiol hemisuccinate''' is a [[synthetic]] [[estrogen]] and a [[derivative]] of [[estradiol]], a naturally occurring [[hormone]] in the human body. It is used in [[hormone replacement therapy]] (HRT) and for other medical purposes. Estradiol hemisuccinate is an [[ester]] of estradiol, specifically the 3-hemisuccinate ester, which modifies the solubility and pharmacokinetics of the parent hormone.
-== Chemical Properties ==
+==Pharmacology==
-Estradiol hemisuccinate is a synthetic compound derived from estradiol. Its chemical structure includes a succinate group attached to estradiol. The chemical formula is C22H28O6.
+Estradiol hemisuccinate acts as an [[agonist]] of the [[estrogen receptor]], mimicking the effects of endogenous estradiol. It is used to treat symptoms associated with [[menopause]], such as [[hot flashes]], [[vaginal atrophy]], and [[osteoporosis]]. The hemisuccinate ester form allows for different routes of administration, including oral and parenteral, and can influence the duration of action of the drug.
-== Medical Uses ==
+==Medical Uses==
-Estradiol hemisuccinate is used in medicine for the following purposes:
+Estradiol hemisuccinate is primarily used in hormone replacement therapy for menopausal women. It helps alleviate symptoms of estrogen deficiency and can also be used in the treatment of certain types of [[breast cancer]] and [[prostate cancer]].
-* '''Hormone Replacement Therapy''': It is employed as a component of hormone replacement therapy (HRT) to supplement estrogen levels in individuals, particularly women, who may experience hormonal imbalances due to menopause or other medical conditions.
-* '''Treatment of Menopausal Symptoms''': HRT, including estradiol hemisuccinate, is prescribed to alleviate symptoms such as hot flashes, vaginal dryness, and mood changes that can occur during menopause.
+==Side Effects==
+Common side effects of estradiol hemisuccinate include [[nausea]], [[headache]], [[breast tenderness]], and [[weight gain]]. Long-term use of estrogen therapy has been associated with an increased risk of [[breast cancer]], [[endometrial cancer]], and [[cardiovascular disease]].
-* '''Osteoporosis Prevention''': Estrogen therapy can help maintain bone density and reduce the risk of osteoporosis, a condition characterized by weakened and brittle bones.
+==Chemistry==
+The chemical structure of estradiol hemisuccinate is characterized by the addition of a succinate group to the estradiol molecule. This modification increases the water solubility of the compound, which can be advantageous for certain formulations and routes of administration.
-== Administration ==
+==See Also==
-Estradiol hemisuccinate is typically administered through various routes, including oral tablets, transdermal patches, and vaginal creams or rings, depending on the specific medical indication and patient preferences.
+* [[Estradiol]]
+* [[Hormone replacement therapy]]
+* [[Estrogen receptor]]
+* [[Menopause]]
-== Safety and Regulation ==
+==References==
-The use of estradiol hemisuccinate in hormone replacement therapy is subject to medical regulation, and its administration should be carried out under the supervision and guidance of a healthcare professional. It is important to consider the individual's medical history and risk factors when prescribing hormone therapy.
+{{Reflist}}
-== Research and Studies ==
-Research on estrogen compounds, including estradiol hemisuccinate, continues to explore their effectiveness, safety, and potential benefits in addressing various medical conditions associated with hormonal imbalances.
-{{stubd}}
-[[Category:Chemical Compounds]]
-[[Category:Hormone Replacement Therapy]]
 [[Category:Estrogens]]
-[[Category:Menopause]]
+[[Category:Hormone replacement therapy]]
-[[Category:Osteoporosis]]
+[[Category:Steroid estrogens]]
+[[Category:Prodrugs]]
+<gallery>
+File:Estradiol succinate.svg|Estradiol hemisuccinate
+</gallery>