Tioclomarol: Difference between revisions

Tioclomarol
INN
Drug class
Routes of administration
Pregnancy category
Bioavailability
Metabolism
Elimination half-life
Excretion
Legal status
CAS Number
PubChem
DrugBank
ChemSpider
KEGG

Latest revision as of 01:21, 20 February 2025

An anticoagulant medication

Tioclomarol is an anticoagulant medication that is used to prevent the formation of harmful blood clots in the blood vessels. It is a coumarin derivative, similar to other anticoagulants such as warfarin.

Mechanism of Action[edit]

Tioclomarol works by inhibiting the synthesis of vitamin K-dependent clotting factors in the liver. These clotting factors include factor II, factor VII, factor IX, and factor X. By reducing the levels of these factors, tioclomarol decreases the blood's ability to clot, thus preventing thrombosis.

Pharmacokinetics[edit]

Tioclomarol is administered orally and is absorbed through the gastrointestinal tract. It is metabolized in the liver and excreted primarily in the urine. The drug has a long half-life, which allows for once-daily dosing.

Clinical Use[edit]

Tioclomarol is used in the prevention and treatment of venous thromboembolism, including deep vein thrombosis and pulmonary embolism. It is also used in patients with atrial fibrillation to reduce the risk of stroke.

Side Effects[edit]

Common side effects of tioclomarol include bleeding, bruising, and gastrointestinal disturbances. Patients taking tioclomarol require regular monitoring of their International Normalized Ratio (INR) to ensure that their blood is not too thin.

Contraindications[edit]

Tioclomarol is contraindicated in patients with active bleeding, severe liver disease, or hypersensitivity to the drug. It should be used with caution in patients with a history of peptic ulcer disease or hypertension.

Interactions[edit]

Tioclomarol can interact with a variety of medications, including antibiotics, antifungals, and nonsteroidal anti-inflammatory drugs (NSAIDs). These interactions can increase the risk of bleeding or reduce the effectiveness of tioclomarol.

Related pages[edit]

Tioclomarol

@@ Line 1: / Line 1: @@
-'''Tioclomarol''' is a [[rodenticide]], a type of [[pesticide]] specifically designed to kill [[rodent]]s. It belongs to the chemical class of [[coumarin]] derivatives, which are known for their anticoagulant properties. Tioclomarol is used in various parts of the world to control rodent populations, particularly in agricultural settings.
+{{Short description|An anticoagulant medication}}
+{{Drugbox
+| verifiedfields = changed
+| verifiedrevid = 477002123
+| image = Tioclomarol.svg
+| image_size = 200px
+}}
-== History ==
+'''Tioclomarol''' is an [[anticoagulant]] medication that is used to prevent the formation of harmful [[blood clots]] in the [[blood vessels]]. It is a [[coumarin]] derivative, similar to other anticoagulants such as [[warfarin]].
-Tioclomarol was first synthesized in the mid-20th century, during a period of intensive research into anticoagulant rodenticides. This was a response to the growing problem of rodent infestations in urban and agricultural areas, and the increasing resistance of these pests to traditional control methods.
+==Mechanism of Action==
+Tioclomarol works by inhibiting the synthesis of [[vitamin K]]-dependent [[clotting factors]] in the [[liver]]. These clotting factors include [[factor II]], [[factor VII]], [[factor IX]], and [[factor X]]. By reducing the levels of these factors, tioclomarol decreases the blood's ability to clot, thus preventing thrombosis.
-== Mechanism of Action ==
+==Pharmacokinetics==
+Tioclomarol is administered orally and is absorbed through the [[gastrointestinal tract]]. It is metabolized in the liver and excreted primarily in the urine. The drug has a long half-life, which allows for once-daily dosing.
-Like other coumarin derivatives, Tioclomarol works by inhibiting the [[vitamin K]] cycle in the liver of the rodent. This prevents the synthesis of certain [[blood clotting factors]], leading to uncontrolled bleeding and eventually death. The delayed action of the poison gives the rodent time to return to its burrow before dying, reducing the risk of secondary poisoning for predators.
+==Clinical Use==
+Tioclomarol is used in the prevention and treatment of [[venous thromboembolism]], including [[deep vein thrombosis]] and [[pulmonary embolism]]. It is also used in patients with [[atrial fibrillation]] to reduce the risk of [[stroke]].
-== Usage and Application ==
+==Side Effects==
+Common side effects of tioclomarol include [[bleeding]], [[bruising]], and [[gastrointestinal disturbances]]. Patients taking tioclomarol require regular monitoring of their [[International Normalized Ratio]] (INR) to ensure that their blood is not too thin.
-Tioclomarol is typically used in bait formulations, which are placed in areas known to be frequented by rodents. The bait is usually grain-based, to attract the rodents, and contains a small amount of the poison. The rodents consume the bait and the poison, and die a few days later.
+==Contraindications==
+Tioclomarol is contraindicated in patients with active bleeding, severe [[liver disease]], or [[hypersensitivity]] to the drug. It should be used with caution in patients with a history of [[peptic ulcer disease]] or [[hypertension]].
-== Safety and Environmental Concerns ==
+==Interactions==
+Tioclomarol can interact with a variety of medications, including [[antibiotics]], [[antifungals]], and [[nonsteroidal anti-inflammatory drugs]] (NSAIDs). These interactions can increase the risk of bleeding or reduce the effectiveness of tioclomarol.
-While Tioclomarol is effective in controlling rodent populations, it also poses risks to non-target species, including humans and pets. Ingestion of the poison can lead to severe bleeding and death. Therefore, it is important to handle Tioclomarol with care, and to use it in a manner that minimizes exposure to non-target species.
+==Related pages==
+* [[Anticoagulant]]
-In addition, there are concerns about the environmental impact of Tioclomarol, particularly its potential to contaminate water sources and its effects on wildlife. These concerns have led to restrictions on its use in some countries.
+* [[Warfarin]]
-== See Also ==
-* [[Rodenticide]]
-* [[Coumarin]]
 * [[Vitamin K]]
-* [[Pesticide]]
+* [[Thrombosis]]
-[[Category:Rodenticides]]
+[[Category:Anticoagulants]]
-[[Category:Pesticides]]
+<gallery>
-[[Category:Chemical substances]]
+File:Tioclomarol.svg|Tioclomarol
-{{Chem-stub}}
+</gallery>
-{{Pesticide-stub}}