Mestranol/noretynodrel

Mestranol/noretynodrel is a combination of two synthetic hormones, mestranol and noretynodrel, that was used in the first oral contraceptive, Enovid.

History

The combination of mestranol and noretynodrel was first introduced in the United States in 1957 by G.D. Searle and Company, initially as a treatment for menstrual disorders and infertility. It was approved as a contraceptive by the Food and Drug Administration (FDA) in 1960, making it the first oral contraceptive available on the market.

Pharmacology

Mestranol is a synthetic form of estrogen, while noretynodrel is a synthetic form of progesterone. Together, they work to prevent ovulation, alter the cervical mucus to make it more difficult for sperm to reach the egg, and change the lining of the uterus to prevent implantation of a fertilized egg.

Side Effects

Like all medications, mestranol/noretynodrel can cause side effects. These may include nausea, vomiting, headache, bloating, breast tenderness, or weight change. More serious side effects can include blood clots, stroke, and heart attacks.

Contraindications

Mestranol/noretynodrel should not be used by women who are pregnant or who have a history of blood clots, stroke, or heart disease. It should also not be used by women who smoke and are over 35 years old.

See Also

• Oral contraceptives
• Estrogen
• Progesterone
• Food and Drug Administration

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