Cantuzumab ravtansine: Difference between revisions

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{{Drugbox
== Cantuzumab Ravtansine ==
| Verifiedfields = changed
| verifiedrevid = 459588924
| type = mab
| image =
| alt =
| mab_type = mab
| source = zu/o
| target = [[MUC1]]
<!-- Clinical data -->
| tradename =
| Drugs.com =
| MedlinePlus =
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
| pregnancy_US = <!-- A / B            / C / D / X -->
| pregnancy_category=
| legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled -->
| legal_CA = <!-- OTC, Rx-only, Schedule I, II, III, IV, V, VI, VII, VIII -->
| legal_UK = <!-- GSL, P, POM, CD, CD Lic, CD POM, CD No Reg POM, CD (Benz) POM, CD (Anab) POM or CD Inv POM -->
| legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V -->
| legal_status =
| routes_of_administration =
<!-- Pharmacokinetic data -->
| bioavailability =
| protein_bound =
| metabolism =
| elimination_half-life =
| excretion =
<!-- Identifiers -->
| CAS_number_Ref = {{cascite|changed|??}}
| CAS_number = 868747-45-9
| ATCvet =
| ATC_prefix = none
| ATC_suffix =
| PubChem =
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| DrugBank =
| ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}}
| ChemSpiderID = none
| KEGG_Ref = {{keggcite|changed|kegg}}
| KEGG = D10454
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}}
'''Cantuzumab ravtansine''' (huC242-SPDB-DM4) is an [[antibody-drug conjugate]] designed for the treatment of cancers. The humanized [[monoclonal antibody]] ''cantuzumab'' (huC242) is linked to a [[cytotoxic agent]], [[ravtansine]] (DM4).<ref>{{cite journal | author = [[World Health Organization]] | title = International Nonproprietary Names for Pharmaceutical Substances (INN). Proposed INN: List 105 | journal = WHO Drug Information | volume = 25 | issue = 2 | year = 2011 | url = http://whqlibdoc.who.int/druginfo/25_2_2011_INN105.pdf | format=PDF}}</ref> It uses a more hindered [[disulfide]] linkage than [[cantuzumab mertansine]].<ref>[https://books.google.co.uk/books?id=WQgaB6VJq_4C&pg=PA131&lpg=PA131&dq=cantuzumab+ravtansine&source=bl&ots=mngfKcpgS5&sig=KtBfUUK49wrOMHCad3al8LBrE1w&hl=en&sa=X&ved=0CDsQ6AEwBWoVChMI_f2pwrjGxwIVSboaCh0xhQef#v=onepage&q=cantuzumab%20ravtansine&f=false Antibody-Drug Conjugates and Immunotoxins: From Pre-Clinical Development to ...]</ref>


== See also ==
[[File:Ravtansine_ADCs.svg|thumb|right|Diagram of Antibody-Drug Conjugates (ADCs) including Cantuzumab Ravtansine]]
* [[Cantuzumab mertansine]]
* [[ImmunoGen|ImmunoGen Inc]], developer of DM4 based drugs


== References ==
'''Cantuzumab ravtansine''' is an [[antibody-drug conjugate]] (ADC) designed for the treatment of [[cancer]]. It combines a monoclonal antibody targeting the [[CanAg]] antigen with a potent cytotoxic agent, [[ravtansine]]. This ADC is part of a class of targeted cancer therapies that aim to deliver cytotoxic drugs directly to cancer cells, thereby minimizing damage to normal tissues.
<references/>


{{monoclonals for tumors}}
== Mechanism of Action ==


[[Category:Immunology]]
Cantuzumab ravtansine works by specifically binding to the CanAg antigen, which is overexpressed on the surface of certain cancer cells. Once bound, the ADC is internalized by the cancer cell, where the cytotoxic agent, ravtansine, is released. Ravtansine disrupts [[microtubule]] function, leading to cell cycle arrest and apoptosis of the cancer cell.
[[Category:Monoclonal antibodies]]


{{monoclonal-antibody-stub}}
== Development and Clinical Trials ==
{{dictionary-stub1}}
 
{{No image}}
Cantuzumab ravtansine has been evaluated in various [[clinical trials]] to assess its efficacy and safety in treating different types of cancer, including [[breast cancer]] and [[colorectal cancer]]. These trials aim to determine the optimal dosing, therapeutic efficacy, and potential side effects of the ADC.
 
== Advantages and Challenges ==
 
The primary advantage of Cantuzumab ravtansine is its ability to selectively target cancer cells, reducing the systemic toxicity typically associated with conventional chemotherapy. However, challenges remain, such as the development of resistance and the identification of patients who will benefit most from this therapy.
 
== Related Pages ==
 
* [[Antibody-drug conjugate]]
* [[Monoclonal antibody therapy]]
* [[Cancer treatment]]
* [[Targeted therapy]]
 
[[Category:Antibody-drug conjugates]]
[[Category:Cancer treatments]]

Latest revision as of 11:19, 15 February 2025

Cantuzumab Ravtansine[edit]

Diagram of Antibody-Drug Conjugates (ADCs) including Cantuzumab Ravtansine

Cantuzumab ravtansine is an antibody-drug conjugate (ADC) designed for the treatment of cancer. It combines a monoclonal antibody targeting the CanAg antigen with a potent cytotoxic agent, ravtansine. This ADC is part of a class of targeted cancer therapies that aim to deliver cytotoxic drugs directly to cancer cells, thereby minimizing damage to normal tissues.

Mechanism of Action[edit]

Cantuzumab ravtansine works by specifically binding to the CanAg antigen, which is overexpressed on the surface of certain cancer cells. Once bound, the ADC is internalized by the cancer cell, where the cytotoxic agent, ravtansine, is released. Ravtansine disrupts microtubule function, leading to cell cycle arrest and apoptosis of the cancer cell.

Development and Clinical Trials[edit]

Cantuzumab ravtansine has been evaluated in various clinical trials to assess its efficacy and safety in treating different types of cancer, including breast cancer and colorectal cancer. These trials aim to determine the optimal dosing, therapeutic efficacy, and potential side effects of the ADC.

Advantages and Challenges[edit]

The primary advantage of Cantuzumab ravtansine is its ability to selectively target cancer cells, reducing the systemic toxicity typically associated with conventional chemotherapy. However, challenges remain, such as the development of resistance and the identification of patients who will benefit most from this therapy.

Related Pages[edit]

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