Buthalital: Difference between revisions

Latest revision as of 10:56, 15 February 2025

Buthalital[edit]

Buthalital is a barbiturate derivative that has been used in the past as a sedative and anesthetic. It is known for its central nervous system depressant effects, which make it useful in inducing sleep and relaxation in medical settings.

Pharmacology[edit]

Buthalital acts on the gamma-aminobutyric acid (GABA) receptor, enhancing the effects of the neurotransmitter GABA. This action increases chloride ion conductance across the neuronal cell membrane, leading to hyperpolarization and decreased neuronal excitability. As a result, Buthalital produces sedation, hypnosis, and anesthesia.

Medical Uses[edit]

Buthalital has been used primarily as an anesthetic agent in surgical procedures. Its rapid onset and short duration of action make it suitable for induction of anesthesia. However, due to the development of newer anesthetic agents with improved safety profiles, the use of Buthalital has declined.

Side Effects[edit]

The use of Buthalital can lead to several side effects, including:

Due to these potential adverse effects, careful monitoring of patients is required during its administration.

Contraindications[edit]

Buthalital is contraindicated in patients with:

History[edit]

Buthalital was developed in the mid-20th century as part of the search for effective anesthetic agents. It was one of many barbiturates synthesized during this period, each with varying properties and clinical applications.

Related pages[edit]

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-'''Buthalital''' is a barbiturate derivative that has been used in the past as a sedative and hypnotic pharmaceutical drug. Like other barbiturates, Buthalital acts by depressing the central nervous system, leading to effects ranging from mild sedation to total anesthesia. It is a member of a class of drugs known as central nervous system (CNS) depressants, which slow down brain activity, resulting in a calming or drowsy effect.
+{{DISPLAYTITLE:Buthalital}}
-==Pharmacology==
+== Buthalital ==
-The mechanism of action of Buthalital, as with other barbiturates, involves the potentiation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) at the GABA_A receptor complex, which results in an increase in the duration of chloride ion channel opening and thus hyperpolarization of the neuron. This action inhibits neuronal firing, leading to sedative and hypnotic effects. Barbiturates bind to the barbiturate binding site, enhancing the effects of GABA and reducing neuronal excitability.
-==Medical Uses==
+[[File:Buthalital_sodium.svg|thumb|right|Chemical structure of Buthalital sodium]]
-Historically, Buthalital was used for its sedative and hypnotic properties, particularly in the treatment of insomnia and in the induction of anesthesia. However, due to the development of safer alternatives with fewer side effects and lower risk of dependence, its use in clinical practice has significantly declined.
-==Side Effects==
+'''Buthalital''' is a [[barbiturate]] derivative that has been used in the past as a [[sedative]] and [[anesthetic]]. It is known for its [[central nervous system]] depressant effects, which make it useful in inducing [[sleep]] and [[relaxation]] in medical settings.
-The side effects of Buthalital are similar to those of other barbiturates and may include drowsiness, dizziness, confusion, and ataxia. With prolonged use or at higher doses, there is a risk of dependence, tolerance, and withdrawal symptoms upon cessation. Overdose can lead to severe respiratory depression, coma, and death, particularly when combined with other CNS depressants such as alcohol.
-==Legal Status==
+== Pharmacology ==
-The legal status of Buthalital varies by country, but it is generally classified as a controlled substance due to its potential for abuse and dependence.
+Buthalital acts on the [[gamma-aminobutyric acid]] (GABA) receptor, enhancing the effects of the neurotransmitter [[GABA]]. This action increases [[chloride ion]] conductance across the neuronal cell membrane, leading to [[hyperpolarization]] and decreased neuronal excitability. As a result, Buthalital produces [[sedation]], [[hypnosis]], and [[anesthesia]].
+== Medical Uses ==
+Buthalital has been used primarily as an [[anesthetic]] agent in [[surgical procedures]]. Its rapid onset and short duration of action make it suitable for [[induction of anesthesia]]. However, due to the development of newer anesthetic agents with improved safety profiles, the use of Buthalital has declined.
+== Side Effects ==
+The use of Buthalital can lead to several side effects, including:
+* [[Respiratory depression]]
+* [[Hypotension]]
+* [[Bradycardia]]
+* [[Drowsiness]]
+* [[Nausea]] and [[vomiting]]
+Due to these potential adverse effects, careful monitoring of patients is required during its administration.
+== Contraindications ==
+Buthalital is contraindicated in patients with:
+* [[Porphyria]]
+* Severe [[respiratory insufficiency]]
+* [[Hypersensitivity]] to barbiturates
+== History ==
+Buthalital was developed in the mid-20th century as part of the search for effective [[anesthetic]] agents. It was one of many barbiturates synthesized during this period, each with varying properties and clinical applications.
+== Related pages ==
-==See Also==
 * [[Barbiturate]]
-* [[Central nervous system depressant]]
-* [[GABA_A receptor]]
-* [[Insomnia]]
 * [[Anesthesia]]
+* [[Sedative]]
+* [[GABA receptor]]
 [[Category:Barbiturates]]
-[[Category:Sedatives]]
+[[Category:Anesthetics]]
-[[Category:Hypnotics]]
-[[Category:Central nervous system depressants]]
-{{Pharmacology-stub}}
-{{Medicine-stub}}
-{{No image}}