Isoquercetin: Difference between revisions

Latest revision as of 03:58, 13 February 2025

Isoquercetin[edit]

Isoquercetin, also known as isoquercitrin, is a flavonoid compound that belongs to the class of flavonols. It is a glycoside form of quercetin, which is a naturally occurring polyphenol found in many plants. Isoquercetin is known for its potential antioxidant, anti-inflammatory, and antiviral properties.

Chemical Structure[edit]

Isoquercetin is a quercetin molecule bound to a glucose molecule. The chemical structure of isoquercetin is characterized by the attachment of a glucose moiety to the hydroxyl group at the 3-position of the quercetin backbone. This glycosidic linkage enhances the solubility of quercetin in water, making isoquercetin more bioavailable than its aglycone form.

Sources[edit]

Isoquercetin is found in various fruits, vegetables, and herbs. Common dietary sources include apples, onions, grapes, and tea. It is also present in medicinal plants such as Ginkgo biloba and Hypericum perforatum (St. John's Wort).

Biological Activities[edit]

Isoquercetin exhibits several biological activities that contribute to its potential health benefits:

Antioxidant Activity[edit]

Isoquercetin acts as an antioxidant by scavenging free radicals and reducing oxidative stress in the body. This activity helps protect cells from damage and may reduce the risk of chronic diseases such as cardiovascular disease and cancer.

Anti-inflammatory Effects[edit]

The compound has been shown to inhibit the production of pro-inflammatory cytokines and enzymes, thereby reducing inflammation in various tissues. This property makes isoquercetin a potential therapeutic agent for inflammatory conditions such as arthritis and asthma.

Antiviral Properties[edit]

Isoquercetin has demonstrated antiviral activity against several viruses, including the influenza virus and hepatitis C virus. It is believed to interfere with viral replication and enhance the immune response to infections.

Potential Health Benefits[edit]

Due to its biological activities, isoquercetin is being studied for its potential health benefits, which include:

Reducing the risk of cardiovascular diseases by improving endothelial function and lowering blood pressure.
Supporting immune function and enhancing resistance to infections.
Protecting against neurodegenerative diseases by reducing neuroinflammation and oxidative damage in the brain.

Related Pages[edit]

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-'''Isoquercetin''' is a flavonoid, a type of plant pigment with antioxidant properties, found in various fruits, vegetables, and grains. It is a glycoside form of quercetin, meaning it is quercetin bound to a sugar molecule, which in the case of isoquercetin is glucose. This modification enhances its solubility and bioavailability compared to its aglycone counterpart, quercetin. Isoquercetin is of interest in the field of [[Nutrition|nutrition]] and [[Pharmacology|pharmacology]] due to its potential health benefits, including anti-inflammatory, anti-cancer, and cardiovascular protective effects.
+== Isoquercetin ==
+[[File:Isoquercitin.svg|thumb|right|Chemical structure of Isoquercetin]]
+'''Isoquercetin''', also known as '''isoquercitrin''', is a [[flavonoid]] compound that belongs to the class of [[flavonols]]. It is a [[glycoside]] form of [[quercetin]], which is a naturally occurring [[polyphenol]] found in many [[plants]]. Isoquercetin is known for its potential [[antioxidant]], [[anti-inflammatory]], and [[antiviral]] properties.
+== Chemical Structure ==
+Isoquercetin is a [[quercetin]] molecule bound to a [[glucose]] molecule. The chemical structure of isoquercetin is characterized by the attachment of a glucose moiety to the hydroxyl group at the 3-position of the quercetin backbone. This glycosidic linkage enhances the solubility of quercetin in water, making isoquercetin more bioavailable than its aglycone form.
 == Sources ==
-Isoquercetin is naturally present in a wide range of foods. Significant sources include [[Leaf vegetable|leafy vegetables]], [[Berries|berries]], [[Herbs and spices|herbs]], and [[Nuts and seeds|nuts]]. It is also found in high concentrations in certain types of tea, such as [[Green tea|green tea]], and in [[Red wine|red wine]]. The content of isoquercetin in these foods can vary widely depending on factors such as the plant variety, growing conditions, and processing methods.
-== Health Benefits ==
+Isoquercetin is found in various [[fruits]], [[vegetables]], and [[herbs]]. Common dietary sources include [[apples]], [[onions]], [[grapes]], and [[tea]]. It is also present in [[medicinal plants]] such as [[Ginkgo biloba]] and [[Hypericum perforatum]] (St. John's Wort).
-Isoquercetin has been studied for its potential health benefits, which are thought to stem from its antioxidant and anti-inflammatory properties.
+== Biological Activities ==
+Isoquercetin exhibits several biological activities that contribute to its potential health benefits:
+=== Antioxidant Activity ===
+Isoquercetin acts as an [[antioxidant]] by scavenging [[free radicals]] and reducing [[oxidative stress]] in the body. This activity helps protect cells from damage and may reduce the risk of [[chronic diseases]] such as [[cardiovascular disease]] and [[cancer]].
+=== Anti-inflammatory Effects ===
+The compound has been shown to inhibit the production of [[pro-inflammatory cytokines]] and enzymes, thereby reducing [[inflammation]] in various tissues. This property makes isoquercetin a potential therapeutic agent for inflammatory conditions such as [[arthritis]] and [[asthma]].
-=== Cardiovascular Health ===
+=== Antiviral Properties ===
-Research suggests that isoquercetin may contribute to cardiovascular health by improving blood vessel function and reducing inflammation. It may also help lower blood pressure and reduce the risk of heart disease.
-=== Anti-cancer Effects ===
+Isoquercetin has demonstrated antiviral activity against several [[viruses]], including the [[influenza virus]] and [[hepatitis C virus]]. It is believed to interfere with viral replication and enhance the immune response to infections.
-Isoquercetin has been investigated for its potential to inhibit the growth of cancer cells. Studies have shown that it can induce apoptosis (programmed cell death) in various types of cancer cells, including breast, colon, and leukemia cells.
-=== Anti-inflammatory and Antioxidant ===
+== Potential Health Benefits ==
-Isoquercetin's anti-inflammatory and antioxidant effects may help reduce the risk of chronic diseases such as diabetes and arthritis. It may also support immune function and protect against oxidative stress.
-== Safety and Side Effects ==
+Due to its biological activities, isoquercetin is being studied for its potential health benefits, which include:
-Isoquercetin is generally considered safe when consumed in amounts typically found in foods. However, high doses, such as those used in supplements, may cause side effects in some individuals. Potential side effects include upset stomach, headache, and tingling of the extremities. Pregnant and breastfeeding women should avoid high doses of isoquercetin due to insufficient safety data.
-== Research and Clinical Studies ==
+* Reducing the risk of [[cardiovascular diseases]] by improving [[endothelial function]] and lowering [[blood pressure]].
-While the potential health benefits of isoquercetin are promising, more research and clinical studies are needed to fully understand its effects, especially in humans. Current studies are mostly preclinical or conducted in vitro (in test tubes) or in vivo (in animals).
+* Supporting [[immune function]] and enhancing resistance to infections.
+* Protecting against [[neurodegenerative diseases]] by reducing [[neuroinflammation]] and [[oxidative damage]] in the brain.
-== Conclusion ==
+== Related Pages ==
-Isoquercetin is a bioavailable form of quercetin with potential health benefits, including anti-inflammatory, anti-cancer, and cardiovascular protective effects. While it is found in a variety of foods and is generally safe, high doses may cause side effects. Further research is necessary to fully elucidate its therapeutic potential and safety profile.
+* [[Quercetin]]
+* [[Flavonoid]]
+* [[Antioxidant]]
+* [[Glycoside]]
-[[Category:Nutritional supplements]]
 [[Category:Flavonoids]]
-[[Category:Antioxidants]]
-{{medicine-stub}}