OR10W1: Difference between revisions

OR10W1
Symbol	OR10W1
HGNC ID	14857
Alternative symbols	–
Entrez Gene	–
OMIM	–
RefSeq	–
UniProt	–
Chromosome	11q24
Locus supplementary data	–

Latest revision as of 20:45, 30 December 2024

OR10W1 is a gene that encodes a member of the olfactory receptor family of proteins. These proteins are involved in the detection of odor molecules and are part of the G protein-coupled receptor (GPCR) superfamily. Olfactory receptors are responsible for the sense of smell and are located in the olfactory epithelium of the nasal cavity.

Function[edit]

The OR10W1 gene is part of a large family of olfactory receptors that interact with odorant molecules in the nose, initiating a neuronal response that triggers the perception of a smell. These receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals.

Structure[edit]

Olfactory receptors, including OR10W1, are characterized by their 7-transmembrane domain structure, which is a common feature of GPCRs. This structure allows them to traverse the cell membrane and interact with G proteins to transmit signals inside the cell.

Genetic Information[edit]

The OR10W1 gene is located on chromosome 11 at the q24 locus. It is one of many olfactory receptor genes clustered in this region of the genome. The gene is expressed in the olfactory epithelium, where it contributes to the diversity of odorant detection.

Clinical Significance[edit]

While specific clinical implications of the OR10W1 gene are not well-documented, variations in olfactory receptor genes can affect the sense of smell. Research into olfactory receptors can provide insights into anosmia (loss of smell) and other olfactory disorders.

References[edit]

External Links[edit]

@@ Line 1: / Line 1: @@
-'''OR10W1''' is a gene that encodes a protein in the olfactory receptor family. This family is a group of [[G protein-coupled receptors]] that are involved in the detection of smell. The OR10W1 gene is specifically expressed in the [[olfactory epithelium]], a specialized tissue inside the nose that is involved in smell.
-== Structure ==
+{{Infobox gene
-The OR10W1 gene is located on chromosome 1, specifically at 1q44. It spans approximately 1.1 kilobases and consists of a single exon. The encoded protein is 312 amino acids in length. Like other olfactory receptors, it has seven transmembrane domains, a characteristic feature of G protein-coupled receptors.
+| name = OR10W1
+| symbol = OR10W1
+| HGNCid = 14857
+| chromosome = 11
+| arm = q
+| band = 24
+| locus = 11q24
+}}
+'''OR10W1''' is a gene that encodes a member of the olfactory receptor family of proteins. These proteins are involved in the detection of odor molecules and are part of the [[G protein-coupled receptor]] (GPCR) superfamily. Olfactory receptors are responsible for the sense of smell and are located in the [[olfactory epithelium]] of the nasal cavity.
 == Function ==
-The OR10W1 protein is believed to bind to odor molecules in the nose, initiating a neural response that triggers the perception of a smell. The specific ligand or ligands that this receptor binds to are currently unknown. However, it is thought that each olfactory receptor in the family may be responsible for the recognition of a small subset of odorant molecules.
+The OR10W1 gene is part of a large family of olfactory receptors that interact with odorant molecules in the nose, initiating a neuronal response that triggers the perception of a smell. These receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals.
+== Structure ==
+Olfactory receptors, including OR10W1, are characterized by their 7-transmembrane domain structure, which is a common feature of GPCRs. This structure allows them to traverse the cell membrane and interact with G proteins to transmit signals inside the cell.
-== Clinical significance ==
+== Genetic Information ==
-Mutations in the OR10W1 gene have not been linked to any specific diseases. However, the olfactory receptor family as a whole is of interest to researchers due to its potential role in disease. For example, changes in smell are often an early symptom of neurodegenerative diseases like [[Parkinson's disease]] and [[Alzheimer's disease]]. Understanding the function of individual olfactory receptors like OR10W1 could therefore provide insights into these conditions.
+The OR10W1 gene is located on chromosome 11 at the q24 locus. It is one of many olfactory receptor genes clustered in this region of the genome. The gene is expressed in the olfactory epithelium, where it contributes to the diversity of odorant detection.
-[[File:OR10W1 gene location on human chromosome 1.png|thumb|right|300px|Location of the OR10W1 gene on human chromosome 1.]]
+== Clinical Significance ==
+While specific clinical implications of the OR10W1 gene are not well-documented, variations in olfactory receptor genes can affect the sense of smell. Research into olfactory receptors can provide insights into [[anosmia]] (loss of smell) and other olfactory disorders.
-== See also ==
+== See Also ==
 * [[Olfactory receptor]]
 * [[G protein-coupled receptor]]
-* [[Olfactory epithelium]]
+* [[Chromosome 11]]
 == References ==
-<references />
+{{reflist}}
+== External Links ==
+* [https://www.ncbi.nlm.nih.gov/gene/OR10W1 OR10W1 Gene - NCBI]
+* [https://www.genecards.org/cgi-bin/carddisp.pl?gene=OR10W1 OR10W1 Gene - GeneCards]
-[[Category:Genes on human chromosome 1]]
+[[Category:Genes on human chromosome 11]]
+[[Category:Olfactory receptors]]
 [[Category:G protein-coupled receptors]]
-[[Category:Olfactory receptors]]
-{{G protein-coupled receptors}}
-{{Olfactory receptors}}
-{{medicine-stub}}