https://wikimd.org/index.php?action=history&feed=atom&title=Willardiine Willardiine - Revision history 2026-04-25T21:29:46Z Revision history for this page on the wiki MediaWiki 1.44.2 https://wikimd.org/index.php?title=Willardiine&diff=6326650&oldid=prev Prab: CSV import 2025-02-18T12:12:30Z <p>CSV import</p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 12:12, 18 February 2025</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l35">Line 35:</td> <td colspan="2" class="diff-lineno">Line 35:</td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Chem-stub}}</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Chem-stub}}</div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Neuroscience-stub}}</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Neuroscience-stub}}</div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">&lt;gallery&gt;</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">File:Willardiine.svg|Willardiine</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">File:Mariosousa_willardiana_-_Mildred_E._Mathias_Botanical_Garden_-_University_of_California,_Los_Angeles_-_DSC02903.jpg|Mariosousa willardiana at Mildred E. Mathias Botanical Garden</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">File:Willardiine.svg|Willardiine</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">File:AMPA_receptor.png|AMPA receptor</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">File:AMPA_Receptor.png|AMPA receptor</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">File:Kainate_receptor.png|Kainate receptor</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">File:Willardiine_biosyn.jpg|Willardiine biosynthesis</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">File:Willardiine_Synthesis.png|Willardiine synthesis</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">File:General_Structure_of_Willardiine_Antagonist.png|General structure of Willardiine antagonist</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">&lt;/gallery&gt;</ins></div></td></tr> </table> Prab https://wikimd.org/index.php?title=Willardiine&diff=5336742&oldid=prev Prab: CSV import 2024-02-29T19:42:24Z <p>CSV import</p> <p><b>New page</b></p><div>&#039;&#039;&#039;Willardiine&#039;&#039;&#039; is a chemical compound that is used as a selective agonist for the AMPA and kainate receptors, two types of ionotropic glutamate receptors in the brain. It is named after the American chemist Robert Willard, who first synthesized it in the 1960s.<br /> <br /> == History ==<br /> <br /> [[Robert Willard]] first synthesized Willardiine in the 1960s. The compound was initially studied for its potential use in agriculture, but its effects on the nervous system were soon recognized. Since then, it has been used as a tool in neuroscience research to study the function of glutamate receptors.<br /> <br /> == Structure and Properties ==<br /> <br /> Willardiine is a derivative of uracil, one of the four nucleobases in the nucleic acid of RNA. It has a pyrimidine ring structure, with two carbonyl groups at the 1 and 3 positions, and an amino group at the 4 position. The 2 position is substituted with a side chain, which can vary to produce different analogs of Willardiine.<br /> <br /> == Biological Activity ==<br /> <br /> Willardiine acts as a selective agonist for the [[AMPA receptor]] and [[kainate receptor]], two types of ionotropic [[glutamate receptor]]s. These receptors are involved in fast synaptic transmission in the central nervous system. By activating these receptors, Willardiine can mimic the effects of glutamate, the main excitatory neurotransmitter in the brain.<br /> <br /> == Uses ==<br /> <br /> Willardiine and its analogs are primarily used in neuroscience research. They are used to study the function of AMPA and kainate receptors, and to investigate the role of these receptors in neurological and psychiatric disorders. Some analogs of Willardiine have also been investigated for their potential use in the treatment of neurodegenerative diseases, such as Alzheimer&#039;s disease and Parkinson&#039;s disease.<br /> <br /> == See Also ==<br /> <br /> * [[AMPA receptor]]<br /> * [[Kainate receptor]]<br /> * [[Glutamate receptor]]<br /> * [[Neurotransmitter]]<br /> * [[Neurodegenerative disease]]<br /> <br /> == References ==<br /> <br /> {{reflist}}<br /> <br /> [[Category:Chemical compounds]]<br /> [[Category:Neuroscience]]<br /> [[Category:Neurotransmitters]]<br /> [[Category:Neurodegenerative diseases]]<br /> {{Chem-stub}}<br /> {{Neuroscience-stub}}</div> Prab