https://wikimd.org/index.php?action=history&feed=atom&title=Volanesorsen 2026-04-27T11:12:49Z Revision history for this page on the wiki MediaWiki 1.44.2 https://wikimd.org/index.php?title=Volanesorsen&diff=6305108&oldid=prev 2025-02-17T01:49:02Z

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Prab https://wikimd.org/index.php?title=Volanesorsen&diff=5292515&oldid=prev 2024-02-25T16:06:45Z

<p>CSV import</p> <p><b>New page</b></p><div>&#039;&#039;&#039;Volanesorsen&#039;&#039;&#039; is an [[antisense oligonucleotide]] that is designed to reduce the production of [[Apolipoprotein C-III]] (ApoC-III), a protein produced in the liver that plays a central role in the regulation of [[plasma triglycerides]].<br /> <br /> == Mechanism of Action ==<br /> <br /> Volanesorsen works by inhibiting the production of ApoC-III, a protein that regulates the breakdown of triglycerides. High levels of ApoC-III can lead to the accumulation of triglycerides in the blood, a condition known as [[hypertriglyceridemia]]. By reducing the levels of ApoC-III, volanesorsen can help lower the levels of triglycerides in the blood.<br /> <br /> == Clinical Trials ==<br /> <br /> Volanesorsen has been studied in several clinical trials for the treatment of familial chylomicronemia syndrome (FCS) and familial partial lipodystrophy (FPL). In these trials, volanesorsen was shown to significantly reduce triglyceride levels in patients with these conditions.<br /> <br /> == Side Effects ==<br /> <br /> The most common side effects of volanesorsen include injection site reactions, flu-like symptoms, and a decrease in platelet count. In some cases, these side effects can be serious and may require medical attention.<br /> <br /> == Approval Status ==<br /> <br /> Volanesorsen has been approved by the [[European Medicines Agency]] (EMA) for the treatment of adult patients with FCS. It is also under review by the [[Food and Drug Administration]] (FDA) in the United States.<br /> <br /> == See Also ==<br /> <br /> * [[Antisense therapy]]<br /> * [[Hypertriglyceridemia]]<br /> * [[Familial chylomicronemia syndrome]]<br /> * [[Familial partial lipodystrophy]]<br /> <br /> [[Category:Drugs]]<br /> [[Category:Antisense therapy]]<br /> [[Category:Hypertriglyceridemia]]<br /> [[Category:Familial chylomicronemia syndrome]]<br /> [[Category:Familial partial lipodystrophy]]<br /> <br /> {{stub}}</div>

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