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Vitronectin - Revision history
2026-04-08T23:20:34Z
Revision history for this page on the wiki
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https://wikimd.com/index.php?title=Vitronectin&diff=6527100&oldid=prev
Prab at 13:29, 18 March 2025
2025-03-18T13:29:59Z
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 13:29, 18 March 2025</td>
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Prab
https://wikimd.com/index.php?title=Vitronectin&diff=6523708&oldid=prev
Prab: CSV import
2025-03-18T02:54:15Z
<p>CSV import</p>
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Prab
https://wikimd.com/index.php?title=Vitronectin&diff=6264173&oldid=prev
Prab: CSV import
2025-02-10T23:41:40Z
<p>CSV import</p>
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 23:41, 10 February 2025</td>
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Prab
https://wikimd.com/index.php?title=Vitronectin&diff=5344850&oldid=prev
Prab: CSV import
2024-03-02T16:34:32Z
<p>CSV import</p>
<p><b>New page</b></p><div>'''Vitronectin''' is a [[glycoprotein]] present in the [[extracellular matrix]] and in [[serum]]. It promotes [[cell adhesion]] and [[spreading]], inhibits the [[membrane-damaging]] effect of the terminal cytolytic [[complement pathway]], and binds to several [[serum proteins]] including the [[anticoagulant]], [[protein S]].<br />
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== Structure ==<br />
Vitronectin is a large, multi-functional glycoprotein. It is composed of a single chain of 459 [[amino acids]] and has a molecular weight of approximately 75 kDa. The protein is rich in [[cysteine]] residues, which form multiple [[disulfide bonds]] that contribute to the stability of the protein's structure.<br />
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== Function ==<br />
Vitronectin plays a key role in a variety of important biological processes. It is involved in [[hemostasis]], the process that causes bleeding to stop, and it also plays a role in [[cell migration]] and [[tissue repair]]. In addition, vitronectin has been found to inhibit [[apoptosis]], or programmed cell death, and to promote [[cell proliferation]] and [[differentiation]].<br />
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== Clinical significance ==<br />
Abnormal levels of vitronectin have been associated with a variety of diseases. Elevated levels of vitronectin have been found in the blood of patients with [[liver cirrhosis]] and [[lung cancer]], and decreased levels have been observed in patients with [[sepsis]]. In addition, mutations in the vitronectin gene have been linked to [[age-related macular degeneration]], a common cause of blindness in older adults.<br />
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== See also ==<br />
* [[Extracellular matrix]]<br />
* [[Glycoprotein]]<br />
* [[Cell adhesion]]<br />
* [[Protein S]]<br />
<br />
[[Category:Glycoproteins]]<br />
[[Category:Extracellular matrix]]<br />
[[Category:Cell adhesion molecules]]<br />
{{Glycoprotein-stub}}<br />
{{Cell-biology-stub}}<br />
{{Medicine-stub}}</div>
Prab