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Vicriviroc - Revision history
2026-04-27T04:28:55Z
Revision history for this page on the wiki
MediaWiki 1.44.2
https://wikimd.org/index.php?title=Vicriviroc&diff=6496235&oldid=prev
Prab at 01:09, 17 March 2025
2025-03-17T01:09:41Z
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 01:09, 17 March 2025</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Antiretroviral-drug-stub}}</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Antiretroviral-drug-stub}}</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">{{No image}}</del></div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> </div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Vicriviroc ==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Vicriviroc ==</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><gallery></div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><gallery></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>File:Vicriviroc_structure.svg|Vicriviroc structure</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>File:Vicriviroc_structure.svg|Vicriviroc structure</div></td></tr>
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Prab
https://wikimd.org/index.php?title=Vicriviroc&diff=6341458&oldid=prev
Prab: CSV import
2025-02-23T21:13:09Z
<p>CSV import</p>
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 21:13, 23 February 2025</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{No image}}</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{No image}}</div></td></tr>
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Prab
https://wikimd.org/index.php?title=Vicriviroc&diff=6281250&oldid=prev
Prab: CSV import
2025-02-11T06:31:58Z
<p>CSV import</p>
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 06:31, 11 February 2025</td>
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Prab
https://wikimd.org/index.php?title=Vicriviroc&diff=5344512&oldid=prev
Prab: CSV import
2024-03-02T16:12:49Z
<p>CSV import</p>
<p><b>New page</b></p><div>'''Vicriviroc''' is an experimental [[antiretroviral drug]] that was under development for the treatment of [[HIV/AIDS]]. It belongs to a class of drugs known as [[CCR5 receptor antagonist]]s, which work by blocking the CCR5 co-receptor on the surface of certain immune cells that HIV uses to enter and infect the cells.<br />
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==History==<br />
Vicriviroc was developed by [[Schering-Plough]], a pharmaceutical company that is now part of [[Merck & Co.]]. The drug was first synthesized in the late 1990s and entered clinical trials in the early 2000s. However, development of vicriviroc was discontinued in 2010 after it failed to meet its primary endpoint in a Phase III clinical trial.<br />
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==Mechanism of Action==<br />
Vicriviroc works by binding to the [[CCR5 receptor]] on the surface of certain immune cells, such as [[T cells]] and [[macrophages]]. This prevents HIV from attaching to the receptor and entering the cell, thereby blocking the virus's ability to replicate and spread.<br />
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==Clinical Trials==<br />
Several clinical trials were conducted to evaluate the safety and efficacy of vicriviroc in patients with HIV/AIDS. These trials showed that vicriviroc was generally well tolerated and could reduce viral load in patients with CCR5-tropic HIV. However, in a Phase III trial, vicriviroc failed to show a significant improvement over existing treatments, leading to the discontinuation of its development.<br />
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==Future Prospects==<br />
Despite the discontinuation of vicriviroc, research into CCR5 antagonists continues, as these drugs offer a different mechanism of action to existing antiretroviral therapies. Other CCR5 antagonists, such as [[maraviroc]], have been approved for use in the treatment of HIV/AIDS.<br />
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[[Category:Antiretroviral drugs]]<br />
[[Category:CCR5 receptor antagonists]]<br />
[[Category:HIV/AIDS]]<br />
{{Antiretroviral-drug-stub}}</div>
Prab