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	~~'''~~Vesiculovirus''' is a genus of viruses in the family [[Rhabdoviridae]], order [[Mononegavirales]]. Mammals, including humans, and insects serve as natural hosts. Diseases associated with this genus include: vesicular stomatitis.		== Vesiculovirus ==

	~~== Taxonomy ==~~		[[File:Viruses-02-00995-g001.png\|thumb\|right\|Electron micrograph of Vesiculovirus]]

	~~The genus~~ Vesiculovirus is ~~one~~ of ~~the seven genera~~ in the family Rhabdoviridae, ~~order Mononegavirales~~. The genus ~~contains~~ the ~~following species:~~		'''Vesiculovirus''' is a genus of viruses in the family [[Rhabdoviridae]]. Members of this genus are known to infect a variety of hosts, including mammals, insects, and fish. The most well-known species within this genus is the [[Vesicular stomatitis virus]] (VSV), which is often used as a model organism in virology research.

	* [[Almpiwar virus]]		== Structure ==
	* [[Carajas virus]]
	* [[Chandipura virus]]		Vesiculoviruses are characterized by their bullet-shaped virions, which are approximately 180 nm in length and 75 nm in diameter. The viral envelope is derived from the host cell membrane and contains glycoproteins that are essential for viral entry into host cells. Inside the envelope, the virus contains a single-stranded, negative-sense [[RNA]] genome.
	* [[Cocal virus]]
	* [[Flanders virus]]
	* [[Isfahan virus]]
	* [[Jurona virus]]
	* [[Maraba virus]]
	* [[Piry virus]]
	* [[~~Radi virus]]~~
	* [[Vesicular stomatitis Alagoas virus]]
	* [[Vesicular stomatitis Indiana virus]]
	* [[Vesicular stomatitis New Jersey virus]]

	== ~~Structure~~ ==		== Genome ==

	~~Vesiculoviruses are enveloped~~, ~~with bullet-shaped~~ and ~~bacilliform geometries~~. ~~The diameter is around 70 nm. Genomes~~ are ~~linear~~, ~~around 11 kb in length~~.		The genome of Vesiculovirus is approximately 11,000 nucleotides in length and encodes five proteins: the nucleoprotein (N), phosphoprotein (P), matrix protein (M), glycoprotein (G), and the large protein (L). These proteins are involved in various stages of the viral life cycle, including replication, transcription, and assembly.

	== Life Cycle ==		== Life Cycle ==

	~~Viral replication is cytoplasmic. Entry into~~ the host cell ~~is achieved by attachment of~~ the viral ~~G glycoproteins to~~ host receptors, ~~which mediates clathrin-mediated~~ endocytosis. ~~Replication follows~~ the ~~negative stranded~~ RNA ~~virus replication model. Negative stranded RNA virus transcription~~, ~~using polymerase stuttering~~ is the ~~method of transcription~~. The ~~virus exits~~ the host cell ~~by budding~~, ~~and tubule-guided viral movement~~. ~~Mammals~~ and ~~insects serve as~~ the ~~natural host. Transmission routes are contamination~~, ~~contact, and airborne particles~~.		The life cycle of Vesiculovirus begins with the attachment of the virus to the host cell surface via interactions between the viral glycoprotein and host cell receptors. Following attachment, the virus enters the cell through endocytosis. Once inside the cell, the viral RNA is released into the cytoplasm, where it is transcribed and replicated by the viral RNA-dependent RNA polymerase.

			The newly synthesized viral proteins and RNA genomes are then assembled into new virions, which bud from the host cell membrane, acquiring their envelope in the process. This budding process often results in cell lysis and the release of new virions, which can go on to infect additional cells.

	== ~~Clinical Significance~~ ==		== Pathogenesis ==

	Vesiculoviruses ~~are notable for their ability to~~ cause ~~disease~~ in ~~both humans and animals~~. ~~The most well-known disease caused by a vesiculovirus is [[Vesicular stomatitis]]~~, ~~which can affect~~ horses, ~~cattle~~, and ~~pigs~~. In humans, infection with ~~a vesiculovirus~~ can ~~cause~~ flu-like symptoms.		Vesiculoviruses can cause a range of diseases in their hosts. In livestock, such as cattle, horses, and pigs, Vesicular stomatitis virus can cause vesicular lesions in the mouth and on the feet, leading to economic losses. In humans, infection with Vesiculovirus is rare but can result in flu-like symptoms.

	== ~~See Also~~ ==		== Research Applications ==

	* [[Viral replication]]		Vesicular stomatitis virus is widely used in research as a model to study viral replication and pathogenesis. Its ability to infect a wide range of host cells and its relatively simple genome make it an ideal candidate for genetic manipulation and vaccine development.
	* [[Viral envelope]]
	* [[Viral transcription]]
	* [[Viral evolution]]

	== ~~References~~ ==		== Related Pages ==

	~~{{Reflist}}~~		* [[Rhabdoviridae]]
			* [[Vesicular stomatitis virus]]
			* [[RNA virus]]
			* [[Virus replication]]

	[[Category:~~Viral diseases~~]]		[[Category:Vesiculovirus]]
	[[Category:~~Virology~~]]		[[Category:Rhabdoviridae]]
	[[Category:~~Virus genera~~]]		[[Category:RNA viruses]]
	~~{{virus-stub}}~~

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2024-03-05T20:51:49Z

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'''Vesiculovirus''' is a genus of viruses in the family [[Rhabdoviridae]], order [[Mononegavirales]]. Mammals, including humans, and insects serve as natural hosts. Diseases associated with this genus include: vesicular stomatitis.

== Taxonomy ==

The genus Vesiculovirus is one of the seven genera in the family Rhabdoviridae, order Mononegavirales. The genus contains the following species:

* [[Almpiwar virus]]
* [[Carajas virus]]
* [[Chandipura virus]]
* [[Cocal virus]]
* [[Flanders virus]]
* [[Isfahan virus]]
* [[Jurona virus]]
* [[Maraba virus]]
* [[Piry virus]]
* [[Radi virus]]
* [[Vesicular stomatitis Alagoas virus]]
* [[Vesicular stomatitis Indiana virus]]
* [[Vesicular stomatitis New Jersey virus]]

== Structure ==

Vesiculoviruses are enveloped, with bullet-shaped and bacilliform geometries. The diameter is around 70 nm. Genomes are linear, around 11 kb in length.

== Life Cycle ==

Viral replication is cytoplasmic. Entry into the host cell is achieved by attachment of the viral G glycoproteins to host receptors, which mediates clathrin-mediated endocytosis. Replication follows the negative stranded RNA virus replication model. Negative stranded RNA virus transcription, using polymerase stuttering is the method of transcription. The virus exits the host cell by budding, and tubule-guided viral movement. Mammals and insects serve as the natural host. Transmission routes are contamination, contact, and airborne particles.

== Clinical Significance ==

Vesiculoviruses are notable for their ability to cause disease in both humans and animals. The most well-known disease caused by a vesiculovirus is [[Vesicular stomatitis]], which can affect horses, cattle, and pigs. In humans, infection with a vesiculovirus can cause flu-like symptoms.

== See Also ==

* [[Viral replication]]
* [[Viral envelope]]
* [[Viral transcription]]
* [[Viral evolution]]

== References ==

{{Reflist}}

[[Category:Viral diseases]]
[[Category:Virology]]
[[Category:Virus genera]]
{{virus-stub}}

Vesiculovirus - Revision history

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