https://wikimd.org/index.php?action=history&feed=atom&title=Vepdegestrant 2026-04-25T01:29:50Z Revision history for this page on the wiki MediaWiki 1.44.2 https://wikimd.org/index.php?title=Vepdegestrant&diff=5367876&oldid=prev 2024-03-06T00:02:51Z

<p>CSV import</p> <p><b>New page</b></p><div>[[File:Vepdegestrant.svg|thumb|{{PAGENAME}}]] &lt;br&gt;&#039;&#039;&#039;Vepdegestrant&#039;&#039;&#039; (developmental code name [[GSK-4716]]) is an [[investigational drug]] that is being studied for the treatment of [[breast cancer]] and [[endometriosis]]. It is a [[selective estrogen receptor degrader]] (SERD) that is orally active.<br /> <br /> == History ==<br /> <br /> Vepdegestrant was first developed by [[GlaxoSmithKline]] (GSK), a British multinational pharmaceutical company. The drug is currently in the [[clinical trial]] phase and is not yet approved for use by the [[Food and Drug Administration]] (FDA) or any other regulatory authority.<br /> <br /> == Mechanism of Action ==<br /> <br /> As a SERD, Vepdegestrant works by binding to the [[estrogen receptor]] and inducing a conformational change that results in the degradation of the receptor. This prevents the receptor from being activated by [[estrogen]], thereby inhibiting the growth of estrogen-dependent tumors.<br /> <br /> == Clinical Trials ==<br /> <br /> Vepdegestrant has undergone several phases of clinical trials. In early trials, it demonstrated promising results in the treatment of breast cancer and endometriosis. However, further studies are needed to confirm these findings and to determine the optimal dosing regimen.<br /> <br /> == Potential Side Effects ==<br /> <br /> As with any drug, Vepdegestrant may cause side effects. These can include [[nausea]], [[vomiting]], [[fatigue]], and [[hot flashes]]. However, the severity and frequency of these side effects can vary among individuals.<br /> <br /> == See Also ==<br /> <br /> * [[Selective estrogen receptor degrader]]<br /> * [[Breast cancer]]<br /> * [[Endometriosis]]<br /> * [[Clinical trial]]<br /> * [[GlaxoSmithKline]]<br /> <br /> == References ==<br /> <br /> {{reflist}}<br /> <br /> [[Category:Investigational drugs]]<br /> [[Category:Selective estrogen receptor degraders]]<br /> [[Category:Breast cancer]]<br /> [[Category:Endometriosis]]<br /> [[Category:GlaxoSmithKline]]<br /> {{pharmacology-stub}}</div>

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