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VUS - Revision history
2026-04-20T23:28:53Z
Revision history for this page on the wiki
MediaWiki 1.44.2
https://wikimd.com/index.php?title=VUS&diff=6531523&oldid=prev
Prab at 18:48, 18 March 2025
2025-03-18T18:48:09Z
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 18:48, 18 March 2025</td>
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Prab
https://wikimd.com/index.php?title=VUS&diff=6524268&oldid=prev
Prab: CSV import
2025-03-18T03:07:13Z
<p>CSV import</p>
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 03:07, 18 March 2025</td>
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Prab
https://wikimd.com/index.php?title=VUS&diff=6268156&oldid=prev
Prab: CSV import
2025-02-11T01:22:53Z
<p>CSV import</p>
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 01:22, 11 February 2025</td>
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Prab
https://wikimd.com/index.php?title=VUS&diff=6197361&oldid=prev
Prab: CSV import
2025-02-08T20:38:24Z
<p>CSV import</p>
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 20:38, 8 February 2025</td>
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Prab
https://wikimd.com/index.php?title=VUS&diff=5289626&oldid=prev
Prab: CSV import
2024-02-25T13:59:17Z
<p>CSV import</p>
<p><b>New page</b></p><div>'''VUS''' or '''Variant of Uncertain Significance''' is a term used in [[genetic testing]] to denote a variant in the genetic sequence that has an unknown effect on the health or development of an individual. The term is often used when the clinical significance of a variant is not yet established. <br />
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== Overview ==<br />
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In the field of [[genetics]], a variant is a change in the [[DNA sequence]]. Most variants are benign and do not cause disease. However, some variants can be pathogenic and lead to genetic disorders. When a variant is identified through genetic testing, it is classified based on the evidence available. If there is not enough evidence to determine whether the variant is benign or pathogenic, it is classified as a Variant of Uncertain Significance (VUS).<br />
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== Implications ==<br />
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A VUS does not provide clear information about an individual's risk of developing a certain disease. Therefore, it is not used to make clinical decisions. However, as more research is conducted and more information becomes available, a VUS may be reclassified into a benign or pathogenic variant.<br />
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== Management ==<br />
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When a VUS is identified, it is recommended to conduct [[family studies]] to gather more information. This can help to determine whether the variant is inherited or occurred de novo. In addition, it is important to continue monitoring the literature and databases for new information about the variant.<br />
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== See also ==<br />
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* [[Genetic testing]]<br />
* [[DNA sequencing]]<br />
* [[Genetic disorder]]<br />
* [[Genetic variation]]<br />
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[[Category:Genetics]]<br />
[[Category:Medical terminology]]<br />
[[Category:Genetic testing]]<br />
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{{stub}}</div>
Prab