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VPS13D - Revision history
2026-04-21T21:34:34Z
Revision history for this page on the wiki
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2025-03-18T01:35:25Z
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2025-02-11T04:18:52Z
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2025-02-08T20:34:35Z
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2024-03-25T02:14:47Z
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'''VPS13D''' is a [[protein]] that in humans is encoded by the ''VPS13D'' [[gene]]. This protein is part of the [[Vacuolar Protein Sorting 13]] (VPS13) family, which includes several other proteins, such as [[VPS13A]], [[VPS13B]], and [[VPS13C]]. Members of this family are involved in various cellular processes, including [[autophagy]], [[vesicle transport]], and [[mitochondrial maintenance]]. The VPS13D protein, in particular, plays a critical role in the regulation of [[mitochondrial function]] and [[cellular energy metabolism]].<br />
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Mutations in the ''VPS13D'' gene have been associated with a range of [[neurological disorders]], including [[movement disorders]] and [[neurodegenerative diseases]]. One of the most notable conditions linked to mutations in this gene is [[VPS13D-related movement disorder]], characterized by symptoms such as [[ataxia]], [[spasticity]], and [[dystonia]]. This condition highlights the importance of VPS13D in [[neuronal function]] and [[brain health]].<br />
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Research into VPS13D has also shed light on its involvement in [[mitophagy]], the selective degradation of [[mitochondria]] by autophagy. This process is crucial for maintaining [[cellular health]] by removing damaged or dysfunctional mitochondria, thus preventing [[mitochondrial diseases]] and contributing to [[cellular homeostasis]].<br />
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The study of VPS13D and its associated pathways offers potential therapeutic targets for treating related neurological disorders. By understanding how mutations in the ''VPS13D'' gene affect cellular and mitochondrial functions, researchers can develop strategies to mitigate these effects and improve patient outcomes.<br />
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[[Category:Genes]]<br />
[[Category:Human proteins]]<br />
[[Category:Neurological disorders]]<br />
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{{medicine-stub}}</div>
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