UniProt - Revision history

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	== UniProt ==		{{DISPLAYTITLE:UniProt}}

	[[File:Uniprot-logo.img.svg\|thumb\|~~Logo of~~ UniProt]]		== Overview ==
			[[File:Uniprot-logo.img.svg\|thumb\|right\|The UniProt logo]]
	'''UniProt''' is a comprehensive, high-quality, and freely accessible ~~resource~~ of protein sequence and functional information. It is a central hub for the collection of functional information on proteins, with accurate, consistent, and rich annotation. ~~The~~ UniProt ~~databases are maintained by the [[UniProt Consortium]], which includes~~ the [[European Bioinformatics Institute]] (EBI), the [[Swiss Institute of Bioinformatics]] (SIB), and the [[Protein Information Resource]] (PIR).		'''UniProt''' (Universal Protein Resource) is a comprehensive, high-quality, and freely accessible database of protein sequence and functional information. It is a central hub for the collection of functional information on proteins, with accurate, consistent, and rich annotation. UniProt is a collaboration between the [[European Bioinformatics Institute]] (EBI), the [[Swiss Institute of Bioinformatics]] (SIB), and the [[Protein Information Resource]] (PIR).

	== History ==		== History ==
	~~The~~ UniProt ~~project~~ was ~~initiated~~ in ~~December~~ 2002 ~~as a~~ merger of three ~~existing~~ protein databases: Swiss-Prot, TrEMBL, and PIR-PSD. The goal was to ~~create~~ a single, ~~comprehensive~~ resource ~~that would provide a more complete and accurate picture of~~ protein ~~sequences~~ and ~~their functions. The first release of UniProt was in 2003~~.		UniProt was created in 2002 by the merger of three major protein sequence databases: Swiss-Prot, TrEMBL, and PIR-PSD. The goal was to provide a single, centralized resource for protein sequence and functional information.

	== Components ==		== Components ==
	UniProt consists of several components:		UniProt consists of several components:

	* '''[[UniProtKB]] (UniProt Knowledgebase)~~'''~~: ~~This is the~~ central database of protein sequences and functional information~~. It~~ is divided into two sections:		* '''[[UniProtKB]]''' (UniProt Knowledgebase): The central database of protein sequences and functional information, which is divided into two sections:
	* '''[[Swiss-Prot]]''': A manually annotated and reviewed section ~~of UniProtKB~~.		* '''[[Swiss-Prot]]''': A manually annotated and reviewed section.
	* '''[[TrEMBL]]''': A ~~computer-annotated~~ section ~~of UniProtKB, which is not reviewed~~.		* '''[[TrEMBL]]''': A section that contains computationally analyzed records that await full manual annotation.

	* '''[[UniParc]] (UniProt Archive)~~'''~~: A comprehensive and non-redundant database that contains most of the publicly available protein sequences in the world.		* '''[[UniParc]]''' (UniProt Archive): A comprehensive and non-redundant database that contains most of the publicly available protein sequences in the world.

	* '''[[UniRef]] (UniProt Reference Clusters)~~'''~~: Provides clustered sets of sequences from UniProtKB and selected UniParc records to obtain complete coverage of sequence space at several resolutions.		* '''[[UniRef]]''' (UniProt Reference Clusters): Provides clustered sets of sequences from UniProtKB and selected UniParc records to obtain complete coverage of sequence space at several resolutions.

	== Features ==		== Features ==
	UniProt provides a wide range of features, including:		UniProt provides a wide range of features, including:

	* Detailed [[~~annotation~~]] of protein ~~sequences~~, ~~including information~~ on ~~function, domain~~ structure, post-translational ~~modifications, variants~~, and ~~more~~.		* Detailed [[protein sequence]] information.
	* Cross-references to other databases, ~~providing a network of biological information.~~		* Functional annotations such as [[protein function]], [[enzyme]] activity, and [[biological process]] involvement.
	* Tools for sequence analysis and ~~retrieval.~~		* Information on [[protein structure]], [[post-translational modification]]s, and [[protein-protein interaction]]s.
	* Regular updates to ensure the most current data is available.		* Cross-references to other databases, including [[genomic]] and [[proteomic]] resources.

	== Access and ~~Use~~ ==		== Access and Tools ==
	UniProt is ~~freely~~ accessible ~~to the public and can be accessed~~ through its website~~. Users can search~~ for ~~proteins by name, function, or sequence,~~ and ~~download~~ data in various ~~formats. The database is widely used by researchers in the fields of [[bioinformatics]]~~, ~~[[molecular biology]], and [[genomics]].~~		UniProt is accessible through its website, which provides a user-friendly interface for searching and retrieving data. It also offers various tools for sequence analysis, including:

	== ~~Related pages~~ ==		* '''BLAST''': For sequence similarity searching.
	* [[~~Protein Data Bank~~]]		* '''Align''': For multiple sequence alignment.
	* [[~~GenBank~~]]		* '''Retrieve/ID mapping''': For converting between different database identifiers.
	* [[~~Ensembl~~]]
			== Applications ==
			UniProt is widely used in [[bioinformatics]], [[molecular biology]], and [[biomedical research]]. It supports a variety of applications, including:

	~~== References ==~~		* [[Drug discovery]] and [[development]].
	~~{{Reflist}}~~		* [[Genomics]] and [[proteomics]] research.
			* [[Functional genomics]] studies.

	== ~~External links~~ ==		== Related pages ==
	* [~~https://www.uniprot.org/ Official UniProt website~~]		* [[Protein structure]]
			* [[Bioinformatics]]
			* [[Genomics]]
			* [[Proteomics]]

			[[Category:Bioinformatics databases]]
			[[Category:Protein structure]]
	[[Category:Biological databases]]		[[Category:Biological databases]]
	~~[[Category:Bioinformatics]]~~
	~~[[Category:Protein structure]]~~

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	~~'''~~UniProt''' is a freely accessible database of protein sequence and functional information, many entries being derived from genome sequencing projects. It contains a large amount of information about the biological function of proteins derived from the research literature.		== UniProt ==

	~~== Overview ==~~		[[File:Uniprot-logo.img.svg\|thumb\|Logo of UniProt]]
	~~The UniProt consortium comprises the~~ [[~~European Bioinformatics Institute]], the [[Swiss Institute~~ of ~~Bioinformatics~~]] and the [[Protein Information Resource]]. It is a collaboration between these institutes that aims to provide the scientific community with a comprehensive, high-quality and freely accessible resource of protein sequence and functional information.

	~~== Content ==~~		'''UniProt''' is a comprehensive, high-quality, and freely accessible resource of protein sequence and functional information. It is a central hub for the collection of functional information on proteins, with accurate, consistent, and rich annotation. The UniProt databases are maintained by the [[UniProt Consortium]], which includes the [[European Bioinformatics Institute]] (EBI), the [[Swiss Institute of Bioinformatics]] (SIB), and the [[Protein Information Resource]] (PIR).
	UniProt ~~provides four core databases~~, ~~each optimized~~ for ~~different uses~~. The databases are the UniProt ~~Knowledgebase (UniProtKB)~~, the ~~UniProt Reference Clusters~~ (~~UniRef~~), the ~~UniProt Archive~~ (~~UniParc~~), and the ~~UniProt Metagenomic and Environmental Sequences~~ (~~UniMES~~) ~~database~~.

	==~~= UniProt Knowledgebase =~~==		== History ==
	The UniProt ~~Knowledgebase (UniProtKB) is the central hub for the collection~~ of ~~functional information on proteins, with accurate, consistent and rich annotation. It consists of two sections~~: ~~UniProtKB/~~Swiss-Prot, ~~which is manually annotated~~ and ~~reviewed~~, and ~~UniProtKB/TrEMBL, which is automatically annotated~~ and ~~not reviewed~~.		The UniProt project was initiated in December 2002 as a merger of three existing protein databases: Swiss-Prot, TrEMBL, and PIR-PSD. The goal was to create a single, comprehensive resource that would provide a more complete and accurate picture of protein sequences and their functions. The first release of UniProt was in 2003.

	==~~= UniProt Reference Clusters =~~==		== Components ==
	~~The UniProt Reference Clusters (UniRef) provide clustered sets of sequences from the~~ UniProt ~~Knowledgebase (including isoforms) and selected UniParc records, in order to obtain complete coverage~~ of ~~the sequence space at~~ several ~~resolutions.~~		UniProt consists of several components:

	~~=== UniProt Archive ===~~		* '''[[UniProtKB]] (UniProt Knowledgebase)''': This is the central database of protein sequences and functional information. It is divided into two sections:
	~~The~~ UniProt ~~Archive (UniParc~~) is ~~a comprehensive and accurate repository~~ of protein sequences, which ~~are sourced from many different databases~~.		* '''[[Swiss-Prot]]''': A manually annotated and reviewed section of UniProtKB.
			* '''[[TrEMBL]]''': A computer-annotated section of UniProtKB, which is not reviewed.

	~~===~~ UniProt ~~Metagenomic~~ and ~~Environmental Sequences ===~~		* '''[[UniParc]] (UniProt Archive)''': A comprehensive and non-redundant database that contains most of the publicly available protein sequences in the world.
	~~The UniProt Metagenomic and Environmental Sequences (UniMES)~~ database ~~is a repository specifically developed for~~ the ~~representation of metagenomic and environmental data~~.

	== ~~See also~~ ==		* '''[[UniRef]] (UniProt Reference Clusters)''': Provides clustered sets of sequences from UniProtKB and selected UniParc records to obtain complete coverage of sequence space at several resolutions.
	* [[~~Protein structure~~]]
	* [[~~Protein–protein interaction~~]]		== Features ==
			UniProt provides a wide range of features, including:

			* Detailed [[annotation]] of protein sequences, including information on function, domain structure, post-translational modifications, variants, and more.
			* Cross-references to other databases, providing a network of biological information.
			* Tools for sequence analysis and retrieval.
			* Regular updates to ensure the most current data is available.

			== Access and Use ==
			UniProt is freely accessible to the public and can be accessed through its website. Users can search for proteins by name, function, or sequence, and download data in various formats. The database is widely used by researchers in the fields of [[bioinformatics]], [[molecular biology]], and [[genomics]].

			== Related pages ==
	* [[Protein Data Bank]]		* [[Protein Data Bank]]
	* [[~~Protein subcellular localization prediction~~]]		* [[GenBank]]
			* [[Ensembl]]

	== References ==		== References ==
	~~<references />~~		{{Reflist}}

	== External links ==		== External links ==
	* [~~http~~://www.uniprot.org/ Official website]		* [https://www.uniprot.org/ Official UniProt website]

	~~[[Category:Protein databases]]~~
	[[Category:Biological databases]]		[[Category:Biological databases]]
	[[Category:~~Science and technology in Europe~~]]		[[Category:Bioinformatics]]
	~~{{stub}}~~		[[Category:Protein structure]]

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'''UniProt''' is a freely accessible database of protein sequence and functional information, many entries being derived from genome sequencing projects. It contains a large amount of information about the biological function of proteins derived from the research literature.

== Overview ==
The UniProt consortium comprises the [[European Bioinformatics Institute]], the [[Swiss Institute of Bioinformatics]] and the [[Protein Information Resource]]. It is a collaboration between these institutes that aims to provide the scientific community with a comprehensive, high-quality and freely accessible resource of protein sequence and functional information.

== Content ==
UniProt provides four core databases, each optimized for different uses. The databases are the UniProt Knowledgebase (UniProtKB), the UniProt Reference Clusters (UniRef), the UniProt Archive (UniParc), and the UniProt Metagenomic and Environmental Sequences (UniMES) database.

=== UniProt Knowledgebase ===
The UniProt Knowledgebase (UniProtKB) is the central hub for the collection of functional information on proteins, with accurate, consistent and rich annotation. It consists of two sections: UniProtKB/Swiss-Prot, which is manually annotated and reviewed, and UniProtKB/TrEMBL, which is automatically annotated and not reviewed.

=== UniProt Reference Clusters ===
The UniProt Reference Clusters (UniRef) provide clustered sets of sequences from the UniProt Knowledgebase (including isoforms) and selected UniParc records, in order to obtain complete coverage of the sequence space at several resolutions.

=== UniProt Archive ===
The UniProt Archive (UniParc) is a comprehensive and accurate repository of protein sequences, which are sourced from many different databases.

=== UniProt Metagenomic and Environmental Sequences ===
The UniProt Metagenomic and Environmental Sequences (UniMES) database is a repository specifically developed for the representation of metagenomic and environmental data.

== See also ==
* [[Protein structure]]
* [[Protein–protein interaction]]
* [[Protein Data Bank]]
* [[Protein subcellular localization prediction]]

== References ==
<references />

== External links ==
* [http://www.uniprot.org/ Official website]

[[Category:Protein databases]]
[[Category:Biological databases]]
[[Category:Science and technology in Europe]]
{{stub}}