U-47700 - Revision history

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	[[Category:Designer drugs]]		[[Category:Designer drugs]]
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			<gallery>
			File:U-47700_fixedstructure.svg\|Chemical structure of U-47700
			File:U-47700.png\|U-47700
			File:Sample_of_U-47700.png\|Sample of U-47700
			</gallery>

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	~~'''~~U-47700~~''' is a synthetic [[opioid]] substance of the [[benzamide]] chemical class that produces [[analgesic]]~~, [~~[relaxing~~]], [[sedative]], and [[euphoric]] effects when administered. It was first developed by a team at [[Upjohn]] in the 1970s and is structurally related to earlier opioid drugs such as [[spiradoline]] and [[U-~~50488]].~~		{{Short description\|Synthetic opioid analgesic}}
			{{Drugbox
			\| verifiedfields = changed
			\| verifiedrevid = 477002
			\| image = U-47700_fixedstructure.svg
			\| image2 = U-47700.png
			\| image3 = Sample_of_U-47700.png
			\| IUPAC_name = (3,4-dichlorophenyl)-[1-(dimethylamino)-2-methylpropyl]methanone
			\| CAS_number = 82657-23-6
			}}

	~~== History ==~~		'''U-47700''' is a synthetic [[opioid]] analgesic drug developed by [[Upjohn]] in the 1970s. It is structurally related to other opioids such as [[AH-7921]] and is known for its potent analgesic effects. U-47700 has gained notoriety as a [[designer drug]] and has been associated with numerous cases of overdose and fatalities.

	U-47700 ~~was first synthesized in~~ the ~~mid~~-~~1970s by~~ a ~~team at Upjohn~~, a ~~pharmaceutical company. It was part of~~ a ~~series~~ of ~~opioids developed by~~ the ~~company in~~ the ~~1970s and 1980s, including~~ [[U-~~50488~~]] and ~~[[U-69,593]]. These drugs were developed as potential analgesics or painkillers, but none of them were ever marketed~~.		==Chemical structure and properties==
			U-47700 is a member of the [[benzamide]] class of opioids. Its chemical structure is characterized by a 3,4-dichlorophenyl group attached to a methanone moiety, with a dimethylamino group at the 1-position and a methyl group at the 2-position of the propyl chain. This structure contributes to its high affinity for the [[mu-opioid receptor]], which is responsible for its analgesic and euphoric effects.

	== Pharmacology ==		==Pharmacology==
			U-47700 acts primarily as a [[mu-opioid receptor]] agonist, similar to other opioids such as [[morphine]] and [[fentanyl]]. It produces effects such as pain relief, sedation, and euphoria. However, it also carries a high risk of respiratory depression, which can be fatal in overdose situations. The potency of U-47700 is estimated to be several times that of morphine.

	U-47700 ~~acts~~ as a [[~~mu-opioid receptor~~]] ~~agonist. It is selective for~~ the ~~μ-opioid receptor and~~ has a high ~~binding affinity~~ for ~~it. This is the same mechanism of action as other opioids, and it is responsible for the drug's analgesic~~ and ~~euphoric effects~~.		==Legal status==
			Due to its potential for abuse and associated health risks, U-47700 has been classified as a controlled substance in many countries. In the [[United States]], it was temporarily placed in [[Schedule I]] of the [[Controlled Substances Act]] in 2016, indicating that it has a high potential for abuse and no accepted medical use.

	== ~~Effects~~ ==		==Health risks and safety==
			The use of U-47700 has been linked to numerous adverse effects, including [[respiratory depression]], [[cardiac arrest]], and death. It is often found in combination with other substances, which can increase the risk of overdose. Users may also experience withdrawal symptoms similar to those of other opioids.

	~~The effects of U-47700 are similar to those of other opioids. They include~~ [[~~analgesia~~]]~~, a sense of relaxation, and euphoria. However, the drug also has a number of adverse effects, including~~ [[~~respiratory depression]], [[constipation]], [[itching~~]]~~, and~~ [[~~addiction~~]]~~. Overdose can lead to fatal respiratory depression.~~		==Related pages==
			* [[Opioid]]
			* [[Designer drug]]
			* [[Controlled Substances Act]]

	== ~~Legal status~~ ==		==References==
			{{Reflist}}

	U-47700 is a controlled substance in many countries, including the United States, where it is a Schedule I drug under the [[Controlled Substances Act]]. It is also controlled under similar laws in other countries, including the United Kingdom, Canada, and Australia.		[[Category:Synthetic opioids]]

	~~== See also ==~~

	* [[List of opioids]]
	* [[Opioid epidemic]]
	* [[Designer drug]]

	[[Category:~~Opioids~~]]
	[[Category:Designer drugs]]		[[Category:Designer drugs]]
	[[Category:~~Synthetic opioids~~]]		[[Category:Controlled substances]]
	~~{{stub}}~~

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2024-02-25T23:04:30Z

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New page

'''U-47700''' is a synthetic [[opioid]] substance of the [[benzamide]] chemical class that produces [[analgesic]], [[relaxing]], [[sedative]], and [[euphoric]] effects when administered. It was first developed by a team at [[Upjohn]] in the 1970s and is structurally related to earlier opioid drugs such as [[spiradoline]] and [[U-50488]].

== History ==

U-47700 was first synthesized in the mid-1970s by a team at Upjohn, a pharmaceutical company. It was part of a series of opioids developed by the company in the 1970s and 1980s, including [[U-50488]] and [[U-69,593]]. These drugs were developed as potential analgesics or painkillers, but none of them were ever marketed.

== Pharmacology ==

U-47700 acts as a [[mu-opioid receptor]] agonist. It is selective for the μ-opioid receptor and has a high binding affinity for it. This is the same mechanism of action as other opioids, and it is responsible for the drug's analgesic and euphoric effects.

== Effects ==

The effects of U-47700 are similar to those of other opioids. They include [[analgesia]], a sense of relaxation, and euphoria. However, the drug also has a number of adverse effects, including [[respiratory depression]], [[constipation]], [[itching]], and [[addiction]]. Overdose can lead to fatal respiratory depression.

== Legal status ==

U-47700 is a controlled substance in many countries, including the United States, where it is a Schedule I drug under the [[Controlled Substances Act]]. It is also controlled under similar laws in other countries, including the United Kingdom, Canada, and Australia.

== See also ==

* [[List of opioids]]
* [[Opioid epidemic]]
* [[Designer drug]]

[[Category:Opioids]]
[[Category:Designer drugs]]
[[Category:Synthetic opioids]]
{{stub}}