Trihexyphenidyl - Revision history

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2025-02-18T04:59:04Z

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← Older revision		Revision as of 04:59, 18 February 2025
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	[[Category:Anticholinergics]]		[[Category:Anticholinergics]]
	[[Category:Muscarinic antagonists]]		[[Category:Muscarinic antagonists]]
			<gallery>
			File:Trihexyphenidyl.svg\|Trihexyphenidyl chemical structure
			File:Trihexyphenidyl_3D.png\|3D model of Trihexyphenidyl
			File:Artane_Synthesis.jpg\|Synthesis of Artane (Trihexyphenidyl)
			File:(R)-Trihexyphenidyl_Structural_Formula_V1.svg\|(R)-Trihexyphenidyl structural formula
			File:(S)-Trihexyphenidyl_Structural_Formula_V1.svg\|(S)-Trihexyphenidyl structural formula
			</gallery>

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2025-02-09T23:52:51Z

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-{{intro}}
+{{Short description|Medication used to treat Parkinson's disease and drug-induced movement disorders}}
-Trihexyphenidyl is an oral anticholinergic agent used predominantly in the symptomatic therapy of [[Parkinson disease]] and movement disorders.
+{{Use dmy dates|date=October 2023}}
-{{use}}
+[[File:Trihexyphenidyl.svg|thumb|Chemical structure of Trihexyphenidyl]]
-Current indications include therapy of symptomatic [[Parkinson disease]], as well as spastic disorders and extrapyramidal disorders due to medications.
+[[File:Trihexyphenidyl_3D.png|thumb|3D model of Trihexyphenidyl]]
-{{dose}}
+'''Trihexyphenidyl''', also known by the brand name '''Artane''', is a [[medication]] primarily used to treat [[Parkinson's disease]] and [[extrapyramidal symptoms]] caused by [[antipsychotic]] medications. It is classified as an [[anticholinergic]] agent.
-{{se}}
+==Medical uses==
-Common side effects are due to its anticholinergic activity and include [[nervousness]], [[confusion]], [[drowsiness]], [[tachycardia]], [[blurred vision]], [[constipation]], [[dry mouth]], [[nausea]] and [[urinary retention]].
+Trihexyphenidyl is used to manage symptoms of [[Parkinson's disease]], such as [[tremor]], [[rigidity]], and [[bradykinesia]]. It is also effective in treating [[drug-induced parkinsonism]] and other [[extrapyramidal side effects]] associated with the use of antipsychotic medications.
-{{coststubd}}
+==Mechanism of action==

Prab: Created page with "{{intro}} Trihexyphenidyl is an oral anticholinergic agent used predominantly in the symptomatic therapy of Parkinson disease and movement disorders. {{livtox}} Trihex..."

2019-05-02T15:38:01Z

Created page with "{{intro}} Trihexyphenidyl is an oral anticholinergic agent used predominantly in the symptomatic therapy of Parkinson disease and movement disorders. {{livtox}} Trihex..."

New page

{{intro}}
Trihexyphenidyl is an oral anticholinergic agent used predominantly in the symptomatic therapy of [[Parkinson disease]] and movement disorders.

{{livtox}}
Trihexyphenidyl has not been associated with serum enzyme elevations during treatment, but has been implicated in rare cases of acute liver injury.

{{moa}}
Trihexyphenidyl is an anticholinergic agent that blocks the central cholinergic receptors, helping to balance cholinergic transmission in the basal ganglia. Trihexyphenidyl may also block dopamine reuptake and storage in central sites thus increasing dopaminergic activity. The exact mechanism(s) by which the anticholinergic agents are beneficial for symptoms of [[Parkinson disease]] is unknown. They are used largely in early Parkinsonism and as adjunctive therapy with levodopa or more potent anti[[Parkinson disease]] agents. Trihexyphenidyl was approved for use in the United States in 1949 and has been in use since.

{{use}}
Current indications include therapy of symptomatic [[Parkinson disease]], as well as spastic disorders and extrapyramidal disorders due to medications.

{{dose}}
Trihexyphenidyl is available in tablets of 2 and 5 mg, and as an elixir of 2 mg/5 mL in generic forms and formerly under the brand name Artane. The recommended dose is 2 to 5 mg three times daily.

{{se}}
Common side effects are due to its anticholinergic activity and include [[nervousness]], [[confusion]], [[drowsiness]], [[tachycardia]], [[blurred vision]], [[constipation]], [[dry mouth]], [[nausea]] and [[urinary retention]].
{{antiparkinson agents}}

{{coststubd}}