https://wikimd.org/index.php?action=history&feed=atom&title=TriclabendazoleTriclabendazole - Revision history2026-04-27T03:33:26ZRevision history for this page on the wikiMediaWiki 1.44.2https://wikimd.org/index.php?title=Triclabendazole&diff=5540567&oldid=prevPrab at 12:16, 7 April 20242024-04-07T12:16:18Z<p></p>
<p><b>New page</b></p><div>== '''What is Triclabendazole?''' ==<br />
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Triclabendazole (EGATEN) is an [[anthelmintic]] used to treat [[fascioliasis]] in patients 6 years of age and older.<br />
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[[File:Triclabendazole.png|thumb]]<br />
[[File:Triclabendazole.svg|thumb]]<br />
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== '''What are the uses of this medicine?''' ==<br />
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* This medicine is used to treat [[fascioliasis]] in patients 6 years of age and older.<br />
* Fascioliasis is an infectious disease caused by the parasitic flatworms [[Fasciola hepatica]] and gigantica, also known as [[Liver fluke|liver flukes]]. <br />
* The initial infection is characterized by fever, abdominal pain, and increase elevation in liver enzymes. <br />
* Over months to years, the disease may become chronic with occasional pain in the abdomen, [[jaundice]], anemia, and blockage of bile ducts where adult flukes live. <br />
* During this phase, parasite eggs are present in the stool.<br />
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== '''How does this medicine work?''' ==<br />
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* Triclabendazole is an [[anthelmintic]] against [[Fasciola]] species.<br />
* The mechanism by which triclabendazole exhibits its effect against Fasciola species is not fully elucidated. <br />
* Studies in vitro and/or in infected animals suggest that '''triclabendazole and its active metabolites (sulfoxide and sulfone) are absorbed by the tegument of the immature and mature worms, leading to a decrease of the resting membrane potential, inhibition of tubulin function as well as protein and enzyme synthesis. '''<br />
* These metabolic disturbances are associated with inhibition of motility, disruption of the surface as well as ultrastructure that includes '''inhibition of spermatogenesis and vitelline cells'''.<br />
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== '''Who Should Not Use this medicine ?''' ==<br />
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This medicine cannot be used in patients with:<br />
* known [[hypersensitivity]] to triclabendazole and/or to other benzimidazole derivatives or to any of the excipients in EGATEN.<br />
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== '''What drug interactions can this medicine cause?''' ==<br />
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* No specific clinical drug interaction studies have been conducted for triclabendazole. <br />
* However, in vitro data suggest the potential for increased plasma concentrations of''' CYP2C19 substrates''' with concomitant use of triclabendazole.<br />
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== '''Is this medicine FDA approved?''' ==<br />
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* It was approved for use in the United States in 2019.<br />
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== '''How should this medicine be used?''' ==<br />
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'''Recommended Dosage'''<br />
* The recommended dose of EGATEN is 2 doses of '''10 mg/kg''' given 12 hours apart in patients 6 years of age and older. <br />
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'''Administration'''<br />
* The 250 mg tablets are functionally scored and divisible into two equal halves of 125 mg. <br />
* If the dosage cannot be adjusted exactly, round the dose upwards.<br />
* Take EGATEN orally with food. <br />
* EGATEN tablets can be swallowed whole or divided in half and taken with water or crushed and administered with applesauce. <br />
* The crushed tablet mixed with applesauce is stable for up to 4 hours.<br />
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== '''What are the dosage forms and brand names of this medicine?''' ==<br />
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This medicine is available in fallowing doasage form:<br />
* '''As Tablets:''' 250 mg, functionally scored<br />
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This medicine is available in fallowing brand namesː<br />
*'''EGATEN'''<br />
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=='''What side effects can this medication cause?'''==<br />
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The most common side effects of this medicine include:<br />
* abdominal pain<br />
* [[hyperhidrosis]]<br />
* nausea<br />
* decreased appetite<br />
* headache<br />
* urticaria<br />
* diarrhea<br />
* vomiting<br />
* musculoskeletal chest pain<br />
* [[pruritus]]<br />
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==''' What special precautions should I follow?''' ==<br />
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* This medicine may prolong QT interval. <br />
* Monitor [[ECG]] in patients with a history of QT prolongation or who are taking medications which prolong the QT interval. <br />
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== '''What to do in case of emergency/overdose?''' ==<br />
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The reported symptom of overdosage following ingestion of approximately 54 mg/kg of EGATEN (approximately 2.7 times the recommended dose) was nausea. <br />
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'''Management for overdosage'''<br />
* Management can be done by osmotic [[diuresis]].<br />
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== '''Can this medicine be used in pregnancy?''' ==<br />
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* There are no available data on EGATEN use in pregnant women to inform a drug-associated risk of major birth defects, miscarriage or adverse maternal or fetal outcomes. <br />
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=='''Can this medicine be used in children?'''==<br />
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* Safety and effectiveness of EGATEN has been established in pediatric patients aged 6 years and older.<br />
* Safety and effectiveness of EGATEN in pediatric patients below the age of 6 years have not been established.<br />
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== '''What are the active and inactive ingredients in this medicine?''' ==<br />
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'''Active ingredient: '''<br />
* TRICLABENDAZOLE<br />
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Inactive ingredients: <br />
* LACTOSE MONOHYDRATE <br />
* STARCH, CORN <br />
* HYMETELLOSE <br />
* MAGNESIUM STEARATE <br />
* SILICON DIOXIDE <br />
* FERRIC OXIDE RED <br />
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== '''Who manufactures and distributes this medicine?''' ==<br />
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* Packager: Novartis Pharmaceuticals Corporation<br />
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== '''What should I know about storage and disposal of this medication?''' ==<br />
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* Store in the original container. <br />
* Store below 30°C (86°F).<br />
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{{Anthelmintics}}<br />
{{portal bar|Medicine}}<br />
<br />
[[Category:Anthelmintics]]<br />
[[Category:Benzimidazoles]]<br />
[[Category:Chloroarenes]]<br />
[[Category:Novartis brands]]<br />
[[Category:Phenol ethers]]<br />
[[Category:Veterinary drugs]]<br />
[[Category:World Health Organization essential medicines]]<br />
[[Category:Orphan drugs]]<br />
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