Prab at 17:42, 18 March 2025

2025-03-18T17:42:56Z

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Prab: CSV import

2025-02-04T08:33:47Z

CSV import

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Deepika vegiraju at 08:50, 16 February 2023

2023-02-16T08:50:19Z

New page

== '''What is Treprostinil diolamine?''' ==

* Treprostinil diolamine ('''Orenitram''') is '''a prostacyclin mimetic''' used to treat certain kinds of [[pulmonary arterial hypertension]].
* Treprostinil can help slow down the progression of your disease and improve your ability to exercise.

[[File:Treprostinil.svg|thumb|Treprostinil]]

[[File:Treprostinil.png|thumb|Treprostinil]]

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== '''What are the uses of this medicine?''' ==

* Treprostinil diolamine ('''Orenitram''') is a prescription medicine used to treat [[pulmonary arterial hypertension]] (PAH) which is high blood pressure in the arteries of your lungs.

== '''How does this medicine work?''' ==

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* The major pharmacologic actions of treprostinil are '''direct [[vasodilation]] of pulmonary and systemic arterial vascular beds, inhibition of platelet aggregation, and inhibition of smooth muscle cell proliferation'''.

== '''Who Should Not Use this medicine ?''' ==

This medicine cannot be used in patients with:
* Severe hepatic impairment

== '''What drug interactions can this medicine cause?''' ==

* Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Be sure to mention any of the following:
* another medicine that contains treprostinil, such as [[Remodulin]] or [[Tyvaso]]
* [[gemfibrozil]] (Lopid), or [[rifampin]] (Rifadin, Rimactane)

== '''Is this medicine FDA approved?''' ==

* Treprostinil was approved for use in the United States in May 2002.

== '''How should this medicine be used?''' ==

'''Recommended dosage:'''
* The recommended starting dose of Orenitram is 0.125 mg three times daily (TID) with food, taken approximately 8 hours apart or 0.25 mg twice daily (BID) with food, taken approximately 12 hours apart.
* Titrate by 0.125 mg TID or by 0.25 mg or 0.5 mg BID, not more frequently than every 3 to 4 days as tolerated.
* If transitioning from [[intravenous]] (IV) or [[subcutaneous]] (SC) Remodulin®, the Orenitram dose should be increased while simultaneously decreasing the IV/SC infusion rate.

'''Dose Adjustment in Patients with Hepatic Impairment:'''
* Initiate at 0.125 mg BID.
* Increment at 0.125 mg BID not more frequently than every 3 to 4 days.
* Avoid use in patients with moderate hepatic impairment.

'''Dose Adjustment for Use with CYP2C8 Inhibitors:'''
* When co-administered with strong CYP2C8 inhibitors (e.g., [[gemfibrozil]]) the initial dose is 0.125 mg BID with 0.125 mg BID dose increments not more frequently than every 3 to 4 days.

'''Administration:'''
* Treprostinil comes as extended-release (long acting) tablets to take by mouth.
* Orenitram is usually taken 3 times a day (about every 8 hours) or 2 times a day (about every 12 hours).
* Your healthcare provider will tell you how often you should take Orenitram.
* If you have side effects, your healthcare provider may tell you to change your dose or when you take Orenitram.
* Take Orenitram with food.
* Swallow Orenitram tablets whole.
* Do not split, chew, crush, or break your Orenitram tablets.
* Do not take Orenitram tablets that are damaged or broken.
* If Orenitram tablets are not taken whole, they may release too much medicine at one time. T
* his can lead to side effects.
* You may see the tablet shell in your stools (bowel movements).
* This is usually normal. The tablet shell is not digested. If you have diverticulosis, the tablet shell may get stuck in a blind pouch or diverticulum in your intestine.
* If you miss your dose of Orenitram, take the missed dose as soon as possible with food.
* If you miss 2 or more doses of Orenitram, call your healthcare provider to see if you need to change your dose.
* If you take too much Orenitram, call your healthcare provider or go to the nearest hospital emergency room right away.
* If you take the medicine Remodulin and your healthcare provider is switching you to Orenitram, your healthcare provider will decrease your dose of Remodulin over a period of time when you start taking Orenitram.

== '''What are the dosage forms and brand names of this medicine?''' ==

This medicine is available in fallowing doasage form:
* As Extended-Release Tablets: 0.125 mg, 0.25 mg, 1 mg, 2.5 mg and 5 mg.

This medicine is available in fallowing brand namesː
* '''Orenitram'''

=='''What side effects can this medication cause?'''==

The most common side effects of this medicine include:
* headache
* [[diarrhea]]
* [[nausea]]
* vomiting
* flushing
* pain in arms and legs
* jaw pain

* Orenitram can cause serious side effects, including worsening of PAH symptoms.

==''' What special precautions should I follow?''' ==

* Abrupt discontinuation or sudden large reductions in dosage of Orenitram may result in worsening of PAH symptoms.'
* The tablet shell does not dissolve. The biologically inert components of the tablet remain intact during gastrointestinal transit and are eliminated in the feces as an insoluble shell.
* It is not known if Orenitram passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby during treatment with Orenitram.
* Treprostinil therapy has not been associated with serum enzyme elevations above the rate in control subjects and has not been linked to instances of clinically apparent [[acute liver injury]].

== '''What to do in case of emergency/overdose?''' ==

Symptoms of overdosage may include:
* severe headache, nausea, vomiting, [[diarrhea]], and [[hypotension]].

Management of overdosage:
* {{overdose}}

== '''Can this medicine be used in pregnancy?''' ==

* Limited published data from case reports with Orenitram use in pregnant women are not sufficient to assess for a drug-associated risk of major birth defects, miscarriage, or adverse maternal or fetal outcomes.
* It is not known if Orenitram will harm your unborn baby.

=='''Can this medicine be used in children?'''==

* Safety and effectiveness in pediatric patients have not been established.

== '''What are the active and inactive ingredients in this medicine?''' ==

* '''Active ingredient:''' treprostinil diolamine
* '''Inactive ingredients:''' xylitol, maltodextrin, sodium lauryl sulfate, magnesium stearate, cellulose acetate, triethyl citrate, polyvinyl alcohol, titanium dioxide, polyethylene glycol, and talc. In addition, tablets may contain colorants FD&C Blue #2, iron oxide yellow, and iron oxide red. The imprint ink contains shellac glaze, ethanol, isopropyl alcohol, iron oxide black, n-butyl alcohol, and propylene glycol.

== '''Who manufactures and distributes this medicine?''' ==

* [[United Therapeutics Corporation|United Therapeutics Corp.]], Research Triangle Park, NC 27709 USA
* Copyright 2019, United Therapeutics Corp. All rights reserved.
* ORENITRAM is a registered trademark of United Therapeutics Corp.

== '''What should I know about storage and disposal of this medication?''' ==

* Store at 68 to 77°F (20 to 25°C).

{{coststubd}}
{{Antithrombotics}}
{{PAH rx}}
{{Prostaglandins}}
{{Prostanoidergics}}
{{Portal bar | Medicine}}

[[Category:Acetic acids]]
[[Category:Orphan drugs]]
[[Category:Phenol ethers]]
[[Category:Prostaglandins]]
[[Category:Secondary alcohols]]

Treprostinil diolamine - Revision history

Prab at 17:42, 18 March 2025

Prab: CSV import

Deepika vegiraju at 08:50, 16 February 2023