https://wikimd.org/index.php?action=history&feed=atom&title=Trehalase_deficiencyTrehalase deficiency - Revision history2026-04-25T11:35:44ZRevision history for this page on the wikiMediaWiki 1.44.2https://wikimd.org/index.php?title=Trehalase_deficiency&diff=2169036&oldid=prevDeepika vegiraju at 17:33, 10 December 20202020-12-10T17:33:55Z<p></p>
<p><b>New page</b></p><div>== '''Alternate names''' ==<br />
Trehalose intolerance<br />
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== '''Definition''' ==<br />
Trehalase deficiency is a [[metabolic]] condition in which the body lacks an enzyme called trehalase and is not able to convert [[trehalose]], a [[disaccharide]] (sugar composed of two [[monosaccharide]]s) into glucose (sugar composed of one monosaccharide). <br />
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== '''Summary''' ==<br />
* [[Trehalose]] is found naturally in [[mushrooms]], algae and insects. Trehalose may additionally be found in manufactured food products, medications, and cosmetics. <br />
* For trehalose to be digested and absorbed by the digestive system, it must be broken down into [[glucose]]. '''Individuals with this deficiency are therefore unable to breakdown and absorb trehalose'''.<br />
* This may lead to vomiting, abdominal discomfort and diarrhea after eating foods containing trehalose.<br />
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== '''Epidemiology''' ==<br />
Studies suggest that this condition is very rare in general; however it is more frequent in Greenland natives (where it has been reported in 8% of the population). Unfortunately for the rare diseases, there's often not a calculated incidence or prevalence. There is no official method for tracking these conditions. It is possible that the incidence is underreported given the similarity of symptoms to other more common digestive disorders such as irritable bowel syndrome. As the use of trehalose increases, we may see an increase in cases reported in the medical literature. <br />
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== '''Cause''' ==<br />
* Trehalase deficiency is caused by mutations in the '''TREH gene'''. The TREH gene codes for an [[enzyme]] '''that breaks down [[trehalose]]''', a sugar made of two glucose molecules ([[disaccharide]]) '''into a digestible sugar or glucose''', called a monosaccharide. <br />
* When there is a '''mutation in the TREH gene, the enzyme has reduced or absent function''', which results in '''undigested sugar entering into the bowel''' (digestive system). There, it goes through a process called [[fermentation]], where sugars are converted to acids, gases, or alcohol. This leads to the production of gases, diarrhea, and other symptoms of abdominal pain and discomfort.<br />
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== '''Inheritance''' ==<br />
Both [[autosomal recessive]] and [[autosomal dominant]] inheritance patterns have been described in the medical literature.<br />
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== '''Signs and symptoms''' ==<br />
Individuals that have trehalase deficiency experience abdominal discomfort after consuming foods that contains trehalose, a type of sugar. The symptoms are typically similar to [[irritable bowel syndrome]] and might include: bloating, abdominal pain, diarrhea, vomiting, and gas.<br />
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== '''Diagnosis''' ==<br />
== '''Treatment''' ==<br />
Treatment involves avoidance or restriction of products that contain [[trehalose]].<br />
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{{stb}}</div>Deepika vegiraju