https://wikimd.org/index.php?action=history&feed=atom&title=Tralokinumab 2026-04-27T12:33:45Z Revision history for this page on the wiki MediaWiki 1.44.2 https://wikimd.org/index.php?title=Tralokinumab&diff=5281590&oldid=prev 2024-02-25T06:24:40Z

<p></p> <p><b>New page</b></p><div>&#039;&#039;&#039;Tralokinumab&#039;&#039;&#039; is a [[monoclonal antibody]] designed for the treatment of [[asthma]] and [[atopic dermatitis]]. It works by targeting [[interleukin 13]], a [[cytokine]] involved in inflammatory responses.<br /> [[File:Tralokinumab 5L6Y.png|Tralokinumab 5L6Y|thumb]]<br /> == Mechanism of Action ==<br /> Tralokinumab is a human [[IgG4]] monoclonal antibody that specifically binds to interleukin 13 (IL-13) and inhibits its interaction with the IL-13 receptor. IL-13 is a central mediator in the pathogenesis of allergic inflammation, such as asthma and atopic dermatitis. By blocking IL-13, tralokinumab reduces inflammatory response, which can lead to an improvement in symptoms.<br /> <br /> == Clinical Trials ==<br /> Tralokinumab has been studied in several [[clinical trial]]s for its effectiveness in treating asthma and atopic dermatitis. In a Phase IIb study, tralokinumab showed a significant reduction in the annual asthma exacerbation rate compared to placebo. In a Phase III study for atopic dermatitis, tralokinumab showed significant improvements in the Eczema Area and Severity Index (EASI) score and the Dermatology Life Quality Index (DLQI) score compared to placebo.<br /> <br /> == Side Effects ==<br /> Common side effects of tralokinumab include [[headache]], [[nasopharyngitis]], and upper respiratory tract infection. Serious side effects can include hypersensitivity reactions, including anaphylaxis.<br /> <br /> == Approval ==<br /> Tralokinumab was approved for use in the European Union in April 2021 for the treatment of moderate to severe atopic dermatitis in adults who are candidates for systemic therapy.<br /> <br /> == See Also ==<br /> * [[List of monoclonal antibodies]]<br /> * [[Clinical trial]]<br /> * [[Asthma]]<br /> * [[Atopic dermatitis]]<br /> <br /> [[Category:Monoclonal antibodies]]<br /> [[Category:Drugs for asthma]]<br /> [[Category:Drugs for dermatologic diseases]]<br /> {{Monoclonals for immune system}}<br /> {{Interleukin receptor modulators}}<br /> {{stub}}</div>

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