https://wikimd.org/index.php?action=history&feed=atom&title=Timeline_of_tuberous_sclerosisTimeline of tuberous sclerosis - Revision history2026-04-25T08:11:55ZRevision history for this page on the wikiMediaWiki 1.44.2https://wikimd.org/index.php?title=Timeline_of_tuberous_sclerosis&diff=6430519&oldid=prevPrab: CSV import2025-03-05T21:12:38Z<p>CSV import</p>
<p><b>New page</b></p><div>== Timeline of Tuberous Sclerosis ==<br />
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[[File:Désiré-Magloire_Bourneville.jpg|Désiré-Magloire Bourneville|thumb|right]]<br />
The timeline of [[tuberous sclerosis]] chronicles the key discoveries and developments in understanding this genetic disorder, which affects multiple organ systems and is characterized by the growth of benign tumors.<br />
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=== 19th Century ===<br />
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* '''1862''': The first known description of tuberous sclerosis was made by [[E. von Recklinghausen]], who noted the presence of "sclerotic" lesions in the brain.<br />
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* '''1880''': [[Désiré-Magloire Bourneville]], a French neurologist, provided a detailed description of the disease, which he termed "sclérose tubéreuse des circonvolutions cérébrales". Bourneville's work laid the foundation for understanding the neurological aspects of the disorder.<br />
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[[File:TuberousSclerosis-BournevilleBrissaud.jpg|Bourneville and Brissaud's illustration of tuberous sclerosis|thumb|left]]<br />
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* '''1881''': [[Félix Balzer]] described the skin lesions associated with tuberous sclerosis, known as "adenoma sebaceum" (now called facial angiofibromas).<br />
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=== Early 20th Century ===<br />
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* '''1908''': [[Heinrich Vogt]] identified the classic triad of symptoms: seizures, intellectual disability, and facial angiofibromas, which became known as "Vogt's triad".<br />
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* '''1911''': [[File:TuberousSclerosis-Rayer-ColourSmall.jpg|Illustration of tuberous sclerosis by Rayer|thumb|right]]<br />
[[E. Rayer]] published a comprehensive account of the disease, further elucidating its clinical manifestations.<br />
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* '''1921''': [[Jan van der Hoeve]] described retinal phakomas, a key ocular manifestation of tuberous sclerosis, contributing to the understanding of its systemic nature.<br />
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[[File:Retinal_phakoma_(1921_drawing_by_Jan_van_der_Hoeve).jpg|Retinal phakoma drawing by Jan van der Hoeve|thumb|left]]<br />
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=== Mid to Late 20th Century ===<br />
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* '''1954''': [[File:Stoddart_80.jpg|Stoddart's work on tuberous sclerosis|thumb|right]]<br />
[[E. Stoddart]] advanced the understanding of the genetic basis of tuberous sclerosis, suggesting an autosomal dominant inheritance pattern.<br />
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* '''1970s''': The development of [[computed tomography]] (CT) and [[magnetic resonance imaging]] (MRI) allowed for better visualization of brain lesions in patients with tuberous sclerosis.<br />
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* '''1987''': The [[Tuberous Sclerosis Alliance]] was founded, providing support and advocacy for individuals affected by the disorder.<br />
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=== 21st Century ===<br />
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* '''2000s''': The identification of the [[TSC1]] and [[TSC2]] genes, which are responsible for the majority of cases of tuberous sclerosis, marked a significant advancement in genetic research.<br />
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* '''2010s''': The development of [[mTOR inhibitors]], such as [[everolimus]], provided new therapeutic options for managing the symptoms of tuberous sclerosis, particularly in reducing the size of renal angiomyolipomas and subependymal giant cell astrocytomas.<br />
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== Related Pages ==<br />
* [[Tuberous sclerosis]]<br />
* [[Genetic disorders]]<br />
* [[Neurology]]<br />
* [[Dermatology]]<br />
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[[Category:Medical timelines]]<br />
[[Category:Genetic disorders]]</div>Prab