https://wikimd.org/index.php?action=history&feed=atom&title=Telavancin 2026-04-27T01:44:39Z Revision history for this page on the wiki MediaWiki 1.44.2 https://wikimd.org/index.php?title=Telavancin&diff=5369020&oldid=prev 2024-03-06T04:44:41Z

<p>CSV import</p> <p><b>New page</b></p><div>[[File:Telavancin.png|thumb|{{PAGENAME}}]]&lt;br&gt;&#039;&#039;&#039;Telavancin&#039;&#039;&#039; is a [[lipoglycopeptide]] [[antibiotic]] used in the treatment of certain [[bacterial infections]]. It is a semi-synthetic derivative of [[vancomycin]], and was approved by the [[Food and Drug Administration|FDA]] in 2009.<br /> <br /> ==Mechanism of Action==<br /> Telavancin inhibits [[cell wall]] synthesis in bacteria by binding to the [[D-alanyl-D-alanine]] terminus of the cell wall precursor [[lipid II]]. This prevents the incorporation of lipid II into the growing bacterial cell wall, leading to cell death. Telavancin also disrupts bacterial cell membrane function, which contributes to its bactericidal activity.<br /> <br /> ==Clinical Use==<br /> Telavancin is indicated for the treatment of [[skin and skin structure infections]] caused by susceptible [[Gram-positive bacteria]], including [[methicillin-resistant Staphylococcus aureus|MRSA]]. It is also used in the treatment of [[hospital-acquired pneumonia]] and [[ventilator-associated pneumonia]] caused by Staphylococcus aureus, including MRSA.<br /> <br /> ==Side Effects==<br /> Common side effects of telavancin include [[nausea]], [[vomiting]], and [[diarrhea]]. Serious side effects can include [[kidney damage]], [[QT interval]] prolongation, and [[Clostridium difficile]] infection.<br /> <br /> ==Pharmacokinetics==<br /> Telavancin is administered intravenously. It has a half-life of approximately 8 hours and is primarily excreted in the urine.<br /> <br /> ==See Also==<br /> * [[Vancomycin]]<br /> * [[Lipoglycopeptide]]<br /> * [[Antibiotic]]<br /> * [[Methicillin-resistant Staphylococcus aureus|MRSA]]<br /> * [[Hospital-acquired pneumonia]]<br /> * [[Ventilator-associated pneumonia]]<br /> <br /> [[Category:Antibiotics]]<br /> [[Category:Lipoglycopeptides]]<br /> [[Category:Pharmacology]]<br /> <br /> {{Pharmacology-stub}}</div>

Prab