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	~~'''~~Teflurane''' is a [[halogenated ether]] that was previously used for [[general anesthesia]]. It is a colorless, nonflammable liquid that has a sweet, ethereal odor. Teflurane was first synthesized in the 1960s and was introduced into clinical practice in the 1970s. However, it was withdrawn from the market in the 1980s due to its high rate of [[hepatotoxicity]] and its potential to cause [[malignant hyperthermia]].		{{DISPLAYTITLE:Teflurane}}

	== ~~History~~ ==		== Overview ==
	Teflurane ~~was first synthesized in the 1960s by~~ [[~~Janssen Pharmaceutica~~]]~~, a Belgian pharmaceutical company. It was introduced into clinical practice in the 1970s~~ as ~~a potential replacement for~~ [[~~halothane~~]]~~, a commonly used anesthetic at the time~~. ~~However, teflurane was found to have~~ a ~~high rate~~ of ~~hepatotoxicity~~, which ~~led~~ to ~~its withdrawal from the market in the 1980s~~.		'''Teflurane''' is a [[halogenated ether]] used as an [[inhalational anesthetic]]. It is part of a class of compounds known as [[volatile anesthetics]], which are used to induce and maintain [[general anesthesia]] during [[surgical procedures]].

	== ~~Pharmacology~~ ==		== Chemical Structure ==
	Teflurane is a ~~halogenated ether~~, ~~which means~~ it ~~is a type~~ of [[~~volatile anesthetic~~]]~~. It works by depressing~~ the central nervous system, ~~which~~ results in a loss of consciousness and ~~a lack of sensation~~. ~~However~~, ~~teflurane has a high rate of hepatotoxicity~~, ~~which means it can cause damage to~~ the liver. It is ~~also known~~ to ~~trigger malignant hyperthermia, a potentially fatal reaction to certain drugs used during general~~ anesthesia.		[[File:Teflurane.svg\|thumb\|right\|Chemical structure of Teflurane]]
			Teflurane is characterized by its chemical structure, which includes a fully fluorinated carbon chain. This structure contributes to its stability and low reactivity, making it suitable for use in medical settings.

			== Mechanism of Action ==
			Teflurane, like other volatile anesthetics, works by modulating the activity of [[ion channels]] in the [[central nervous system]]. It is believed to enhance the activity of [[GABA]] receptors, leading to increased [[inhibitory neurotransmission]] and a reduction in [[neuronal excitability]]. This results in the loss of [[consciousness]] and [[analgesia]] necessary for surgical procedures.

			== Pharmacokinetics ==
			Teflurane is administered via inhalation, allowing for rapid uptake and distribution in the body. Its low [[blood-gas partition coefficient]] facilitates quick induction and recovery from anesthesia. The compound is primarily eliminated through exhalation, with minimal [[metabolism]] in the [[liver]].

			== Clinical Use ==
			Teflurane is used in various surgical settings due to its rapid onset and recovery profile. It is particularly useful in [[outpatient surgery]] where quick recovery is desired. The anesthetic is often used in combination with other agents to achieve balanced anesthesia.

	== Side Effects ==		== Side Effects ==
	~~The most common~~ side effects of ~~teflurane~~ include nausea, vomiting, and dizziness~~. It can also cause a rapid heart rate, low blood pressure, and respiratory depression~~. In rare cases, ~~teflurane can~~ cause malignant hyperthermia, a ~~potentially fatal reaction~~ that ~~can occur during general anesthesia~~.		Common side effects of Teflurane include [[nausea]], [[vomiting]], and [[dizziness]]. In rare cases, it may cause [[malignant hyperthermia]], a serious condition that requires immediate medical intervention. Patients with a history of [[liver disease]] or [[respiratory disorders]] should be monitored closely when using Teflurane.

	== ~~Current Use~~ ==		== Safety and Precautions ==
	Teflurane ~~is no longer used~~ in ~~clinical practice due to its high rate~~ of ~~hepatotoxicity and its~~ potential ~~to cause malignant hyperthermia. However~~, ~~it is still used in research settings to study~~ the ~~effects~~ of ~~halogenated ethers on the central nervous system~~.		Proper monitoring of [[vital signs]] is essential during the administration of Teflurane. Anesthesia providers should be trained in the management of potential complications, including airway management and the treatment of malignant hyperthermia.

	== ~~See Also~~ ==		== Related Pages ==
	* [[~~Halogenated ether~~]]		* [[Inhalational anesthetic]]
	* [[General anesthesia]]		* [[General anesthesia]]
	* [[~~Hepatotoxicity~~]]		* [[Volatile anesthetic]]
	* [[~~Malignant hyperthermia~~]]		* [[GABA receptor]]

	[[Category:Anesthetics]]		[[Category:Anesthetics]]
	[[Category:Halogenated ethers]]		[[Category:Halogenated ethers]]
	~~[[Category:Pharmacology]]~~
	~~[[Category:Medical history]]~~

	~~{{stub}}~~

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2024-02-25T21:08:21Z

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'''Teflurane''' is a [[halogenated ether]] that was previously used for [[general anesthesia]]. It is a colorless, nonflammable liquid that has a sweet, ethereal odor. Teflurane was first synthesized in the 1960s and was introduced into clinical practice in the 1970s. However, it was withdrawn from the market in the 1980s due to its high rate of [[hepatotoxicity]] and its potential to cause [[malignant hyperthermia]].

== History ==
Teflurane was first synthesized in the 1960s by [[Janssen Pharmaceutica]], a Belgian pharmaceutical company. It was introduced into clinical practice in the 1970s as a potential replacement for [[halothane]], a commonly used anesthetic at the time. However, teflurane was found to have a high rate of hepatotoxicity, which led to its withdrawal from the market in the 1980s.

== Pharmacology ==
Teflurane is a halogenated ether, which means it is a type of [[volatile anesthetic]]. It works by depressing the central nervous system, which results in a loss of consciousness and a lack of sensation. However, teflurane has a high rate of hepatotoxicity, which means it can cause damage to the liver. It is also known to trigger malignant hyperthermia, a potentially fatal reaction to certain drugs used during general anesthesia.

== Side Effects ==
The most common side effects of teflurane include nausea, vomiting, and dizziness. It can also cause a rapid heart rate, low blood pressure, and respiratory depression. In rare cases, teflurane can cause malignant hyperthermia, a potentially fatal reaction that can occur during general anesthesia.

== Current Use ==
Teflurane is no longer used in clinical practice due to its high rate of hepatotoxicity and its potential to cause malignant hyperthermia. However, it is still used in research settings to study the effects of halogenated ethers on the central nervous system.

== See Also ==
* [[Halogenated ether]]
* [[General anesthesia]]
* [[Hepatotoxicity]]
* [[Malignant hyperthermia]]

[[Category:Anesthetics]]
[[Category:Halogenated ethers]]
[[Category:Pharmacology]]
[[Category:Medical history]]

{{stub}}

Teflurane - Revision history

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