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	<id>https://wikimd.com/index.php?action=history&amp;feed=atom&amp;title=Tangles</id>
	<title>Tangles - Revision history</title>
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	<updated>2026-04-07T04:15:54Z</updated>
	<subtitle>Revision history for this page on the wiki</subtitle>
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	<entry>
		<id>https://wikimd.com/index.php?title=Tangles&amp;diff=6526570&amp;oldid=prev</id>
		<title>Prab at 13:19, 18 March 2025</title>
		<link rel="alternate" type="text/html" href="https://wikimd.com/index.php?title=Tangles&amp;diff=6526570&amp;oldid=prev"/>
		<updated>2025-03-18T13:19:27Z</updated>

		<summary type="html">&lt;p&gt;&lt;/p&gt;
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				&lt;td colspan=&quot;2&quot; style=&quot;background-color: #fff; color: #202122; text-align: center;&quot;&gt;← Older revision&lt;/td&gt;
				&lt;td colspan=&quot;2&quot; style=&quot;background-color: #fff; color: #202122; text-align: center;&quot;&gt;Revision as of 13:19, 18 March 2025&lt;/td&gt;
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&lt;/table&gt;</summary>
		<author><name>Prab</name></author>
	</entry>
	<entry>
		<id>https://wikimd.com/index.php?title=Tangles&amp;diff=6520283&amp;oldid=prev</id>
		<title>Prab: CSV import</title>
		<link rel="alternate" type="text/html" href="https://wikimd.com/index.php?title=Tangles&amp;diff=6520283&amp;oldid=prev"/>
		<updated>2025-03-18T01:05:58Z</updated>

		<summary type="html">&lt;p&gt;CSV import&lt;/p&gt;
&lt;table style=&quot;background-color: #fff; color: #202122;&quot; data-mw=&quot;interface&quot;&gt;
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				&lt;td colspan=&quot;2&quot; style=&quot;background-color: #fff; color: #202122; text-align: center;&quot;&gt;← Older revision&lt;/td&gt;
				&lt;td colspan=&quot;2&quot; style=&quot;background-color: #fff; color: #202122; text-align: center;&quot;&gt;Revision as of 01:05, 18 March 2025&lt;/td&gt;
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&lt;/table&gt;</summary>
		<author><name>Prab</name></author>
	</entry>
	<entry>
		<id>https://wikimd.com/index.php?title=Tangles&amp;diff=6236689&amp;oldid=prev</id>
		<title>Prab: CSV import</title>
		<link rel="alternate" type="text/html" href="https://wikimd.com/index.php?title=Tangles&amp;diff=6236689&amp;oldid=prev"/>
		<updated>2025-02-10T18:02:01Z</updated>

		<summary type="html">&lt;p&gt;CSV import&lt;/p&gt;
&lt;table style=&quot;background-color: #fff; color: #202122;&quot; data-mw=&quot;interface&quot;&gt;
				&lt;col class=&quot;diff-marker&quot; /&gt;
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				&lt;td colspan=&quot;2&quot; style=&quot;background-color: #fff; color: #202122; text-align: center;&quot;&gt;← Older revision&lt;/td&gt;
				&lt;td colspan=&quot;2&quot; style=&quot;background-color: #fff; color: #202122; text-align: center;&quot;&gt;Revision as of 18:02, 10 February 2025&lt;/td&gt;
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&lt;/table&gt;</summary>
		<author><name>Prab</name></author>
	</entry>
	<entry>
		<id>https://wikimd.com/index.php?title=Tangles&amp;diff=5281574&amp;oldid=prev</id>
		<title>Prab: CSV import</title>
		<link rel="alternate" type="text/html" href="https://wikimd.com/index.php?title=Tangles&amp;diff=5281574&amp;oldid=prev"/>
		<updated>2024-02-25T06:24:21Z</updated>

		<summary type="html">&lt;p&gt;CSV import&lt;/p&gt;
&lt;p&gt;&lt;b&gt;New page&lt;/b&gt;&lt;/p&gt;&lt;div&gt;&amp;#039;&amp;#039;&amp;#039;Tangles&amp;#039;&amp;#039;&amp;#039; are twisted fibers of another protein called tau (τ) that build up inside cells. They are a pathological entity primarily known for their involvement in [[Alzheimer&amp;#039;s disease]]. &lt;br /&gt;
&lt;br /&gt;
== Overview ==&lt;br /&gt;
&lt;br /&gt;
Tangles are aggregates of the microtubule-associated protein tau which has become hyperphosphorylated and accumulate in the cell bodies of neurons as paired helical filaments. They are associated with a number of neurological diseases known as [[tauopathies]], the most common of which is Alzheimer&amp;#039;s disease.&lt;br /&gt;
&lt;br /&gt;
== Role in Alzheimer&amp;#039;s Disease ==&lt;br /&gt;
&lt;br /&gt;
In Alzheimer&amp;#039;s disease, the tau protein undergoes chemical changes, becoming hyperphosphorylated, and begins to pair with other threads, forming tangles and disrupting the transportation system. This is thought to result in the disintegration of the microtubules in the brain cells, collapsing the neuron&amp;#039;s transport system. This collapse damages the communication between neurons, leading to cell death.&lt;br /&gt;
&lt;br /&gt;
== Tauopathies ==&lt;br /&gt;
&lt;br /&gt;
Tauopathies are a group of neurodegenerative diseases associated with the pathological aggregation of tau protein in the human brain. They are characterized by the presence of neurofibrillary tangles. Tauopathies include Alzheimer&amp;#039;s disease, [[Pick&amp;#039;s disease]], and [[frontotemporal dementia]] and parkinsonism linked to chromosome 17.&lt;br /&gt;
&lt;br /&gt;
== See Also ==&lt;br /&gt;
&lt;br /&gt;
* [[Alzheimer&amp;#039;s disease]]&lt;br /&gt;
* [[Neurofibrillary tangle]]&lt;br /&gt;
* [[Tau protein]]&lt;br /&gt;
* [[Tauopathies]]&lt;br /&gt;
&lt;br /&gt;
== References ==&lt;br /&gt;
&lt;br /&gt;
&amp;lt;references /&amp;gt;&lt;br /&gt;
&lt;br /&gt;
[[Category:Neurodegenerative disorders]]&lt;br /&gt;
[[Category:Alzheimer&amp;#039;s disease]]&lt;br /&gt;
[[Category:Neuropathology]]&lt;br /&gt;
&lt;br /&gt;
{{stub}}&lt;/div&gt;</summary>
		<author><name>Prab</name></author>
	</entry>
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