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	'''TNFRSF12A'''~~, also known as '''~~Tumor Necrosis Factor Receptor Superfamily Member 12A~~''',~~ is a ~~protein~~ that ~~in humans is encoded by the TNFRSF12A gene. It is~~ a member of the [[tumor necrosis factor receptor]] ~~superfamily, a group~~ of ~~proteins that play a crucial role~~ in ~~controlling~~ cell ~~survival~~ and ~~death~~.		{{DISPLAYTITLE:TNFRSF12A}}
			{{Infobox gene
			\| name = TNFRSF12A
			\| image = <!-- Image removed -->
			\| caption = <!-- Caption removed -->
			\| HGNCid = 11906
			\| symbol = TNFRSF12A
			\| alt_symbols = FN14
			\| EntrezGene = 51330
			\| OMIM = 604967
			\| RefSeq = NM_016639
			\| UniProt = Q9NP84
			\| chromosome = 16
			\| arm = p
			\| band = 13.3
			}}

			'''TNFRSF12A''' (Tumor Necrosis Factor Receptor Superfamily Member 12A) is a [[gene]] that encodes a member of the [[tumor necrosis factor receptor superfamily]]. This receptor is also known as [[FN14]] and is the smallest member of this family. It is involved in various cellular processes, including [[cell proliferation]], [[apoptosis]], and [[inflammation]].

	== Function ==		== Function ==
	TNFRSF12A is a ~~cell surface~~ receptor ~~that is predominantly expressed in~~ [[~~endothelial cells~~]]~~. It binds to a ligand known as~~ [[TWEAK~~]], which is a member of the [[tumor necrosis factor~~]] (TNF) ~~family of cytokines~~. The interaction between ~~TNFRSF12A~~ and TWEAK ~~triggers a series of intracellular~~ signaling ~~events that can lead to cell death~~, ~~proliferation~~, ~~or differentiation~~.		The TNFRSF12A gene product is a receptor for the [[cytokine]] [[TWEAK]] (TNF-like weak inducer of apoptosis). The interaction between FN14 and TWEAK can activate several signaling pathways, including the [[NF-kB]] pathway, which plays a crucial role in [[immune response]] and [[cell survival]].

	== Clinical Significance ==		== Clinical Significance ==
	~~Mutations~~ in the TNFRSF12A ~~gene~~ have been associated with various diseases~~. For instance~~, ~~overexpression of TNFRSF12A has been observed in several types of~~ cancer, ~~including~~ [[~~breast cancer~~]] and [[~~colorectal cancer~~]]. It has ~~also~~ been ~~implicated~~ in ~~autoimmune diseases such as~~ [[~~rheumatoid arthritis~~]] and [[~~lupus~~]].		Alterations in the expression of TNFRSF12A have been associated with various [[diseases]], including [[cancer]], [[atherosclerosis]], and [[autoimmune disorders]]. Overexpression of FN14 has been observed in several types of [[tumors]], suggesting a role in [[tumor progression]] and [[metastasis]].

	== Research ==		== Research ==
	Research ~~into~~ TNFRSF12A is ongoing~~, with studies focusing on~~ its role in disease ~~progression~~ and potential as a therapeutic target. ~~For example, drugs that inhibit~~ the ~~interaction between TNFRSF12A and TWEAK are being investigated for their potential to treat~~ cancer and ~~autoimmune~~ diseases.		Research on TNFRSF12A is ongoing to better understand its role in disease and its potential as a [[therapeutic target]]. Studies are exploring the use of FN14 inhibitors in the treatment of [[cancer]] and other diseases characterized by [[chronic inflammation]].

	[[~~File:TNFRSF12A protein structure.jpg\|thumb\|right\|300px\|The 3D structure of the TNFRSF12A protein. Image from Wikimedia Commons.~~]]

	== See Also ==		== See Also ==
	* [[Tumor necrosis factor receptor]]		* [[Tumor necrosis factor receptor superfamily]]
	* [[~~TWEAK~~]]		* [[Cytokine]]
	* [[~~TNF superfamily~~]]		* [[Apoptosis]]
			* [[NF-kB]]

	== References ==		== References ==
	~~<references />~~		{{Reflist}}

	~~[[Category:Genes]]~~		== External Links ==
	[~~[Category~~:~~Proteins]~~]		* [https://www.ncbi.nlm.nih.gov/gene/51330 TNFRSF12A Gene - NCBI]
	[~~[Category~~:~~Medical genetics]]~~		* [https://www.uniprot.org/uniprot/Q9NP84 TNFRSF12A Protein - UniProt]
	~~[[Category:Oncology]]~~
	~~[[Category:Immunology]~~]

	~~{{medicine-stub}}~~		[[Category:Genes on human chromosome 16]]
			[[Category:Tumor necrosis factor receptor superfamily]]
			[[Category:Apoptosis]]
			[[Category:Immune system]]

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'''TNFRSF12A''', also known as '''Tumor Necrosis Factor Receptor Superfamily Member 12A''', is a protein that in humans is encoded by the TNFRSF12A gene. It is a member of the [[tumor necrosis factor receptor]] superfamily, a group of proteins that play a crucial role in controlling cell survival and death.

== Function ==
TNFRSF12A is a cell surface receptor that is predominantly expressed in [[endothelial cells]]. It binds to a ligand known as [[TWEAK]], which is a member of the [[tumor necrosis factor]] (TNF) family of cytokines. The interaction between TNFRSF12A and TWEAK triggers a series of intracellular signaling events that can lead to cell death, proliferation, or differentiation.

== Clinical Significance ==
Mutations in the TNFRSF12A gene have been associated with various diseases. For instance, overexpression of TNFRSF12A has been observed in several types of cancer, including [[breast cancer]] and [[colorectal cancer]]. It has also been implicated in autoimmune diseases such as [[rheumatoid arthritis]] and [[lupus]].

== Research ==
Research into TNFRSF12A is ongoing, with studies focusing on its role in disease progression and potential as a therapeutic target. For example, drugs that inhibit the interaction between TNFRSF12A and TWEAK are being investigated for their potential to treat cancer and autoimmune diseases.

[[File:TNFRSF12A protein structure.jpg|thumb|right|300px|The 3D structure of the TNFRSF12A protein. Image from Wikimedia Commons.]]

== See Also ==
* [[Tumor necrosis factor receptor]]
* [[TWEAK]]
* [[TNF superfamily]]

== References ==
<references />

[[Category:Genes]]
[[Category:Proteins]]
[[Category:Medical genetics]]
[[Category:Oncology]]
[[Category:Immunology]]

{{medicine-stub}}

TNFRSF12A - Revision history

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