Prab: CSV import

2025-03-18T00:54:02Z

CSV import

← Older revision		Revision as of 00:54, 18 March 2025
Line 46:		Line 46:
	[[Category:Oncogenes]]		[[Category:Oncogenes]]
	{{No image}}		{{No image}}
			__NOINDEX__

Prab: CSV import

2025-02-10T21:44:35Z

CSV import

← Older revision		Revision as of 21:44, 10 February 2025
Line 45:		Line 45:
	[[Category:Human proteins]]		[[Category:Human proteins]]
	[[Category:Oncogenes]]		[[Category:Oncogenes]]
			{{No image}}

Prab: CSV import

2024-12-02T02:15:18Z

CSV import

New page

{{Infobox protein
| name = Transcription factor E3
| symbol = TFE3
| image = 
| width = 
| caption = 
| HGNCid = 11766
| EntrezGene = 7030
| OMIM = 314310
| RefSeq = NM_006512
| UniProt = P19532
| chromosomal_location = Xp11.23
}}

'''Transcription factor E3''' ('''TFE3''') is a [[protein]] encoded by the '''TFE3''' gene in humans. TFE3 is a member of the [[MiT/TFE family]] of transcription factors, which also includes [[TFEB]], [[TFEC]], and [[MITF]]. These transcription factors are involved in the regulation of various cellular processes, including [[autophagy]], [[lysosome biogenesis]], and [[metabolism]].

==Structure==
TFE3 is a basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factor. This structure allows TFE3 to bind DNA and regulate gene expression. The protein contains a basic region that facilitates DNA binding, a helix-loop-helix motif for dimerization, and a leucine zipper that stabilizes the dimer.

==Function==
TFE3 plays a crucial role in the regulation of [[gene expression]] in response to various physiological signals. It is involved in the regulation of genes associated with [[cell growth]], [[proliferation]], and [[differentiation]]. TFE3 is also implicated in the cellular response to [[nutrient availability]] and [[stress]].

TFE3 can translocate to the [[nucleus]] in response to certain signals, where it binds to specific DNA sequences to activate or repress target genes. It is known to interact with other transcription factors and co-regulators to modulate its activity.

==Clinical Significance==
Mutations and translocations involving the TFE3 gene have been associated with several types of [[cancer]], including [[renal cell carcinoma]] and [[alveolar soft part sarcoma]]. In particular, TFE3 gene fusions, such as those with the [[ASPSCR1]] gene, result in the production of chimeric proteins that can drive oncogenesis.

TFE3-related [[renal cell carcinoma]] is characterized by the presence of TFE3 gene fusions and is classified as a distinct subtype of renal cell carcinoma. These tumors often occur in younger patients and may have unique histological features.

==Research==
Ongoing research is focused on understanding the precise mechanisms by which TFE3 regulates gene expression and contributes to disease. Studies are also exploring the potential of targeting TFE3 and its pathways for therapeutic purposes, particularly in cancer treatment.

==Also see==
* [[Transcription factor]]
* [[Gene expression]]
* [[Renal cell carcinoma]]
* [[MiT/TFE family]]
* [[TFEB]]
* [[MITF]]

{{Transcription factors}}
{{Human proteins}}

[[Category:Transcription factors]]
[[Category:Human proteins]]
[[Category:Oncogenes]]

TMC1 - Revision history

Prab: CSV import

Prab: CSV import

Prab: CSV import